Böbrek naklinde kullanılan immünsüpresif tedaviler

Yıl 2016, Cilt: 1 Sayı: 1, 48 - 52, 01.02.2016

Emin Taşkıran , Oytun Erbaş , Harun Akar

Öz

Böbrek nakli sonrası, indüksiyon immünsüpresyon tedavisi için konvansiyonel immünsüpresif tedavi yerine yeni keşfedilen antikorlarla kombine edilmiş standart immünsüpresif tedavi önerilmektedir. Bu ajanlar, anti-lenfosit antikorları (rATG, atgam, alemtuzumab), interlökin 2 reseptör antagonistlerini (basiliksimab), anti-CD20 antikorları (rituksimab) içermektedir. İdame immünsüpresyon tedavisi ise akut rejeksiyonu ve allogreft kaybını, önlemek için gereklidir. Bu ajanlar kalsinörin inhibitörlerini (siklosporin, tacrolimus), kortikosteroidleri (prednizon), antimetabolitleri (azatiyopürin ve MMF), mTOR inhibitörlerini (sirolimus) ve belatacepti içermektedir. Tüm rejimlerin etki ve yan etkileri yapılan çalışmaların ışığında tartışılacaktır.

Anahtar Kelimeler

Böbrek nakli, immünsüpresif ajanlar, immünsüpresif antikor

Kaynakça

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