Synthesis, Characterization, Antimalarial and Antimicrobial activities of Mixed Ibuprofen-Pyrimethamine M(II) Complexes [M = Cd, Co, Zn, Mn]

Yıl 2019, , 30 - 37, 31.12.2019

Mercy Bamigboye , İkechukwu Ejidike

https://doi.org/10.38061/idunas.629389

Cited By: 1

Öz

Mixed complexes of
Ibuprofen-Pyrimethamine were synthesized using Cd(II) Co(II), Zn(II) and
Mn(II). The mixed complexes were characterized based on some physico-chemical
and spectroscopic techniques such as infrared, elemental analysis, conductivity
measurements, and magnetic moment. Based on the results obtained, the complexes
were formulated as [M(L₁)(L₂)]Cl₂ , where M =
metal ion, L₁ = Pyrimethamine, L₂ = Ibuprofen). The
complexes were found to be non-electrolytes. The ligands act as bidentate
towards the central metal ions with deprotonation occurring at the carboxylic
group. The complexes were also analyzed by conductometric titration.
Antimicrobial screening against the selected organisms: Escherichia coli,
Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus substilis, Bacillus
megaterium and Serratia marcescens for the complexes
alongside the free ligands was investigated. Antimalarial study was
investigated for the compounds against Plasmodium
berhei (NK 65 strain). It was observed that the complexes showed
significant potentials against the studied organisms.

Anahtar Kelimeler

Ibuprofen, Antimicrobial, Pyrimethamine, Metal Complexes

Kaynakça

• Abdel-Nasser, M.A., Alaghaz, R.A., Ammar – Hany, M. (2009). Studies on the Chelation of Cyclodiphosph (V) azane Complexes of Co(II), Ni(II), Cu(II), and Pd(II): Preparation, Characterization, Thermal, Solid State Electrical Conductivity, and Biological Activity Studies. J. Phosphorus, Sulfur, and Silicon and the Related Elements. 184(9), 2472-2490. Adibi, H., Zaker, S., Monkaresi, H. (2012). Synthesis and characterization of hydrazide-hydrazone derivatives of 3-pyridine carboxylic acid as antimycobacterial tuberculosis agents. J. Rep. Pharma. Sci. 1(1), 60-66. Ahmed, R.N., Sani, A., Igunnugbemi, O.O. (2009). Antifungal Profiles of Extracts of Vitellaria paradoxa (Shea-Butter) Bark. Ethnobot. leaflets 13(1), 679-688. Alaghaz, A.N.M.A., Farag, R.S., Elnawawy, M.A., Ekawy, A.D.A. (2013). Synthesis and spectral characterization studies of new trimethoprim-diphenylphosphate metal complexes. Int. Jour. Sci. Res. 5(1), 1220-1229. Aragoni, M.C., Arca, M., Demartin, F. (2002). Fluorometric chemosensors. Interaction of toxic heavy metal ions PbII, CdII, and Hg(II) with novel mixed-donor phenanthroline-containing macrocycles: spectrofluorometric, conductometric, and crystallographic studies,” Inorg. Chem. 41(1): 6623–6632. Ayad, M.M. (2002). Spectrophotometric and AAS determination of Ramipril and enalapril through ternary complex formation. J. Pharm. Biomed. Anal. 28(1), 311-321. Babamale, H.F., Lawal, A., Rajee, O.A., Oloyede, E.A. (2006). Synthesis, Characterization and Biological Activity Studies of Mixed Paracetamol - Ascorbic Acid Metal Complexes. J. Appl. Sci. Environ. Manage. 20(4), 1157-1161. Bamigboye, M.O., Tella, A.C., Gbadebo, T.E., Eke, U.B., Obaleye, J.A. (2015). Amodiaquine-Ibuprofen Mixed Metal Complexes: Synthesis, Characterization and Antimicrobial Activities. Centrepoint Journal (Science Edition). 21(2), 84- 93. Cassells, I., Stringer, T., Smith, G.S. (2018). Impact of various lipophilic substituents on ruthenium(II), rhodium(III) and iridium(III) salicylaldimine-based complexes: synthesis, in vitro cytotoxicity studies and DNA interactions. J. Bio. Inorg. Chem. 23(5), 763–774. Ejidike, I.P. (2018). Cu(II) Complexes of 4-[(1E)-N-{2-[(Z)-Benzylidene-amino]ethyl} ethanimidoyl] benzene-1,3-diol Schiff base: Synthesis, spectroscopic, in-vitro antioxidant, antifungal and antibacterial studies. Mol. 23(7) Ejidike, I.P., Ajibade, P.A. (2017). Synthesis, spectroscopic, antibacterial and free radical scavenging studies of Cu(II), Ni(II), Zn(II) and Co(II) complexes of 4,4'-{ethane-1,2-diylbis[nitrilo(1E)eth-1-yl-1-ylidene]}dibenzene-1,3-diol Schiff base. J. Pharm. Sci. Res. 9(5), 593-600. Enermose, E.A., Akporhnonor, E.E., Osakwe, S.A. (2014). Cu (ll) and Ni (lI) Complexes of Sulphamethazine Mixed with Pyrimethamine: Synthesis, Characterization and Antimicrobial Study. Chem. Mat. Res. 6(6), 9 – 14. Huang, T.H., Yan, J., Yang, H., Tan, C., Yang, Y. (2016). Synthesis, structures, and properties of polynuclear silver complexes containing tetra-phosphine ligand with Ag ·C interactions. Austr. J. Chem. 69(1), 336–342. Ibrahim, N.M., Yosef, H.A.A., Ewies, E.F., Mahran, M.R.H., Ali, M.M., Mahmoud, A.E. (2015). Synthesis and Antitumor Evaluation of New Heterocycles Derived from 3-Methyl-2- benzothiazolinone Hydrazone. J. Braz. Chem. Soc. 26(6), 1086-1097. Lawal, A., Obaleye, J.A. (2007). Synthesis, characterization and antibacterial activity of aspirin and paracetamol metal complexes. Nigerian Society for Experimental Biology. Biokemistri. 19(1), 9-15. Li-June M. (2003). Structure and function of metallo-antibiotics. Med. Res. Rev. 23(6), 697-762. Mosiniewicz-Szablewska, E., Slawska-Waniewska, A., Swiatek, K., Nedelko, N., Golebiewski, N. (2003). Magnetic properties of Ni-complexes in a hydrazone structure. Phy. Stat. Solid. (A) Appl. Res.196(1), 213–216. Osowole, A.A., Wakil, S.M. (2015). Synthesis, Characterization and Antimicribial Activity of some Mixed Trimethoprim-Sulfamethoxazole Metal Complexes. World Applied Science Journal. 33(2), 336-342. Padman, S., Sapna, T., Sing, A.P. (2016). Synthesis, Spectral Characterization and Antimicrobial Studies of Schiff Bases and Their Mixed Ligand Metal Complexes of Co(II), Ni(II), Cu(II) and Zn(II). Am. J. Chem. 6(5), 119-125. Raheem, T.M., Al-Noor, T.H., Ismail, A.H. (2014). Preparation, Characterization, and Antibacterial Properties of Mixed Ligand Complexes of L-leucine and Sulfamethoxazole (Antibiotic) with Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) ions. Journal of Advances in Physics Theories and Applications. 27(1), 8-19. Ramachandran, R., Prakash, G., Vijayan, P., Viswanathamurthi, P., Malecki, J.G. (2017). Synthesis of heteroleptic copper(I) complexes with phosphine-functionalized thiosemicarbazones: an efficient catalyst for regioselective N-alkylation reactions. Inorganica. Chimica. Acta. 464(5), 88–93. Recio Despaigne, A.A., Da Silva, J.G., da Costa, P.R., dos Santos, R.G., Beraldo, H. (2014). ROS Mediated Cytotoxic Effect of Copper(II) Hydrazone Complexes against Human Glioma Cells. Molecules. 19, 17202-17220. Renny, J.S., Tomasevich, L.L., Tallmadge, E.H., Collum, D.B. (2013). Method of Continuous Variations: Applications of Job Plots to the Study of Molecular Associations in Organometallic Chemistry. Angew. Chem. Int. Ed. Engl. 52(46), 11998–12013. Safila, N., Lailoona, J. (2014). UV Spectrophotometric Assay of different brands of Cephradine, Am. Association Sci. Technol. 1(4), 84-87. Shaker, S.A., Farina, Y. (2009). Preparing and characterization of some mixed ligands complexes of 1,3,7-trimethylxanthin, ƴ-picoline and thiocyanate with some metal ions. Am. J. sci. res. 5, 20-26. Shaker, S.A., Farina, Y., Mahmmod, S, Eskendar M. (2009). Preparation and study of mixed ligand complexes of caffeine and cyanate with some metal ions. Australian Journal of basic and applied sciences. 3(4), 3337-3340. Shivankar, V.S., Burungale, A,S., Rajmane, MM, Gavali LV.(2012). Synthesis, characterization and catalytic activity of mixed ligand transition metal complexes. Arch. Appl. Sci. Res. 4(5): 2289-2298. Srinivasan, R., Sougandi, I., Venkatesan, R., Sambasiva Rao, P. (2003). Synthesis and room temperature single crystal EPR studies of a dinickel complex having an Ni2(μ-phenoxide)22+ unit supported by a macrocyclic ligand environment [Ni2(L)2(OClO3)2] [L = 2-[(4-methyl-pyridin-2-ylimino)-methyl]-phenol],” Proceedings of the Indian Academy of Sci. 115(2), 91–102. Tella, A.C., Obaleye, J.A. (2010). Synthesis and Biological studies of Co(II) and Cd(II) 5-(3,4,5 trimethoxybenzyl) pyrimidine -2-4-diamine (Trimethoprim) complexes. Int. J. Biol. Chem. Sci. 4(1), 2181-2191. Triathi, I.P., Aarti, K. (2015). Synthesis and characterization of some complexes of copper(II) with L-Asparginine, L-Histidine, L-Lysine. Am. J. Alzh. Dis. Dem. 3(1), 95-103. Waziri, M.B., Fugu, N.P. (2018). Solvent-free Synthesis, Characterization and Antimicrobial Studies of Calcium and Potassium Complexes with Some Cephalosporin Antibiotics. Res. J. Chem. Sci. 8(6), 8 -15.