Antibacterial activities of Some Mixed Isoniazid-Ibuprofen Metal Complexes: Chelation and Characterization

Yıl 2019, Cilt: 2 Sayı: 2, 51 - 63, 31.12.2019

Mercy Bamigboye , İkechukwu Ejidike

https://doi.org/10.38061/idunas.631229

Öz

The input of metallo-pharmaceutical to
biomedical research is of high remarkable effect in drug design either as
therapeutic, diagnostic or MRI imaging agents to mention few. Ranges of d -
orbital transition metals: Cu(II), Zn(II), Mn(II), Ni(II), and Cd(II) complexes
bearing Isoniazid-Ibuprofen mixed ligands have been synthesized. The prepared
complexes were characterized by using microanalytical, infrared spectroscopy
and CHN elemental analysis. FT-IR spectroscopic data showed that the ligands
coordinate to the metal ion via the oxygen and nitrogen donor atoms from
Isoniazid and oxygen of the carboxylic group and oxygen of the hydroxyl group
of Ibuprofen. The elemental analysis measurement supports an octahedral
geometry complexes proposed in line with the electronic structures of the metal
ions. Comparative antibacterial study of the synthesized metal complexes and
their parent ligands against Escherichia
Coli, Staphylococcus aureus, and Pseudomonas aeruginosa microorganisms were carried out. [Ni(ISO)(IBR)Cl₂]
and [Co(ISO)(IBR)Cl₂] exhibited the highest antibacterial activities
than other complexes, however, the metal complex activities were found higher
than the free ligands.

Anahtar Kelimeler

Spectroscopic, Isoniazid, Ligands, Antibacterial

Kaynakça

• Adadey, S.A., Sarfo, J.K. (2016). Copper paracetamol complexes Promising lead antibacterial drug candidates. African Journal of Pure and Applied Chemistry. 10(5), 56-62.
• Alade, P., Irobi, O.N. (1993). Antifungal activities of crude leaf extract of Acalypha wilkesiana. J. Ethnopharcol. 39, 171-174.
• Amolegbe, S.A., Adewuyi, S., Akinremi, C.A., Lawal, A., Obaleye, J.A., Atayese, A.O. (2012). Mn(II), Ni(II), and Cu(II) Complexes of Artemisinin Derivatives: Synthesis, Characterization and Antimicrobial Activities. The pacific journal of science and Technology. 13(1), 424-429. Arounaguiri S., Easwaramoorthy D., Ashokkumar A.(2000). Cobalt(III), nickel(II) and ruthenium(II) complexes of 1,10-phenanthroline family of ligands: DNA binding and photocleavage studies. Proc. Indian Acad. Sci. (Chem. Sci.). 112 (1),1.
• Bamigboye, M.O. Anibijuwon, I.I., Ajiboye, A.E. (2017). Chelation, Characterization And Antimicrobial Studies Of Mixed Nicotinamide - Cloxacillin Metal Complexes. Nig. J. Pure and Appl. Sci. 30 (2).
• Chaudhary, A., Phor, A., Singh, R. V. (2005). Potentially biodynamic tetraaza macrocycles and their manganese complexes: antiandrogen, antimicrobial and PDI studies,” Bioinorganic Chemistry and Applications. 3(3-4),161-177.
• Chohan, Z. H., Supuran, C.T. (2006). Metalloantibiotics: Synthesis,characterization and in-vitro antibacterialstudies on cobalt (II), copper (II), nickel (II) and zinc (II) complexes with Cloxacillin. Journal of Enzyme Inhibition and Medicinal Chemistry, 21(4), 441-448.
• Collins, C.H., Lyne, P.M. and Grange, J.M. (1995). Microbiological methods (7thedn) Butterwort – Heinemann Ltd. Britain. 175-190.
• Diana, E., Chierotti, M.R., Marchese, E.M.C., Croce, G., Milanesio, M., Stanghellini, P.L. (2012). Blue and red shift hydrogen bonds in crystalline cobaltocinium complexes. New J. Chem. 36,1099.
• Diana, E., Chierotti, M.R., Marchese, E.M.C., Croce, G., Milanesio, M., Stanghellini, P.L. (2012). Blue and red shift hydrogen bonds in crystalline cobaltocinium complexes. New J. Chem. 36, 1099.
• Irving, H. M. N. H., Williams, R. J. P. (1953). The stability of transition-metal complexes". J. Chem. Soc. 3192–3210. doi:10.1039/JR9530003192.
• Liebowitz, L. D., Ashbee, H. R., Evans, E. G. V., Chong, Y., Mallatova, N., Zaidi, M., Gibbs, D. (2001). Global Antifungal Surveillance Group. Diagn. Microbiol, Infect. Dis. 4, 27. Maria, K. R. B., Francis, R. N. A., Vasanthi, R. P., Paulraj, A. (2013). Mixed Ligand Complexes Of Nickel(II), Copper(II) And Zinc(II) With Nicotinanilide And Thiocyanate. International Journal of Life science and Pharma research, 3(2),1.
• Mewis, R.E., Archibald, S.J. (2010). Biomedical applications of macrocyclic ligand complexes. Coord. Chem. Rev. 254,1686-1712.
• Mukherjee, R. (2000). Coordination chemistry with pyrazole based chelating ligands: molecular structural aspects. Coord. Chem. Rev. 203,151-218.
• Naglah, A. M., Al-Omar, M. A., El-Megharbel, S. M., Refat, M. S. (2015). Structural, conductometric and antimicrobial investigations of ibuprofen analgesic drug complexes with certain metal ions. International Journal of Pharmacology. 11 (7), 773-785.
• Obaleye, J.A., Adediji, J.F., Adebayo, M.A. (2011). Synthesis and biological activities on metal complexes of 2, 5-diamino-1, 3, 4-thiadiazole derived from semicarbazide hydrochloride. Molecules 16 (7), 5861-5874.
• Ogunniran, K.O., Ajani, O.O., Ehi-Eromosele,C.O., Obaleye, J.A., Adekoya, J.A. and Ajanaku, C.O. (2012). Cu(II) and Fe(III)complexes of Sulphadoxine mixed with Pyrimethamine : Synthesis, Characterization, Antimicrobial andToxicology study. International Journal of Physical Sciences, 7(13), 1998-2005.
• Ogunniran, K.O., Ajannaku, K.O., James, O.O., Ajani, O.O., Adekoya, J.A. and Nwionyi, O.C. (2008). Synthesis, Characterization, Antimicrobial activity and Toxicology study of some metal complexes of mixed antibiotics. African Journal of Pure and Applied Chemistry, 2(7), 69-74.
• Poggi, M., Barroso, R., Costa-Filho, A. J., Barbosa de Barros, H., Pavan, F., Leite, F. C., Gambino, D., Torre, M. H., (2013). New Isoniazid Complexes, Promising Agents Against Mycobacterium tuberculosis. J. Mex. Chem. Soc. 57(3), 198-204.
• Prasad, S., Agarwal, R.K. (2007). Cobalt(II) complexes of various thiosemicarbazones of 4-aminoantipyrine: syntheses, spectral, thermal and antimicrobial studies,” Transition Metal Chemistry, 32(2), 143-149.
• Reddy, N.S., Rao, S.A., Chari. M.A., Kumar, R.V., Jyothy, V., Himabindu, V. (2012). Synthesis and bacterial activity of urea and thiourea derivative of anacardic acid mixture isolated from a natural product cashew nut Shell liquid. Intl. J. Org. Chem., 2, 267-275.
• Sousa, E.H., Basso, L.A., Santos, D.S., Diógenes I.C., Longhinotti, E., Lopes LG, Moreira, S. (2012). Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design. J. Biol. Inorg. Chem.17(2), 275-83. doi: 10.1007/s00775-011-0848-x.
• Tella, A.C., Obaleye, J.A. (2010). Metal-Chelator: Stability constants of Transition Metal complexes of Pyrimidine and Sulphonamide Drugs. Int. J. Chem. Sci. 8 (3), 1675-1683.
• Tella, A.C., Obaleye, J.A. (2013). Solvent-free synthesis, x-ray studies and in vitro inhibitory activities of copper(II) complexes of non-steroidal anti-inflammatory drugs. Research on Chemical Intermediates. doi: 10.1007/s11164-013-1050-1052.
• Willey, J.M., Sherwood, L.M., Woolverton, C.J. (2008). Prescott, Harley and Klein's microbiology. McGraw-Hill,New York, NY, USA, 7th. ed.
• Yıldız, G., Tuba B., Fatma, K.O., Selda O., Mustafa, F.S., Deniz, S.D. (2012). Synthesis of some new urea and thiourea derivatives and evaluation of their antimicrobial activities. Turk. J. Chem., 36, 279-291.