Manyetik Rezonans Görüntüleme Yöntemi ile Beyinde Yaşa Bağlı Hacim Değişikliklerinin İncelenmesi

Yıl 2018, Sayı: 5, 407 - 420, 31.08.2018

Ceyda Hayretdağ Örs , Necip Ozan Tiryakioğlu , Tuncay Varol

Öz

Amaç: Normal beyin yaşlanmasına
yaşa bağlı bilişsel kayıp eşlik eder. Beyinde yaşlanmaya bağlı değişimlerin
tespiti sağlıklı yaşlanma sürecini anlamakta yardımcı olacaktır.  Amacımız beyinde yaşa bağlı hacim
değişikliklerinin incelenmesiyle yaşlılıkta beyinde görülen patolojik
değişimleri tespit ederek bu hacim değişikliklerinin cinsiyet ile ilişkili
olarak farklılık gösterip göstermediğini tespit etmektir.

Yöntem: Çalışma, yaşları 20-80
arasında değişen, 13 erkek ve 16 kadın bireyden oluşan toplam 29 kişilik bir
grubun manyetik rezonans (MR) görüntüleri ile gerçekleştirilmiştir. MR
görüntülerinde sağ ve sol serebral yarıkürelerin, sağ ve sol frontal ve
temporal lobların hacimleri Cavlieri yöntemi ile ölçülmüştür.

Bulgular: Volümlerdeki bu azalma
oranının erkeklerde kadınlardan daha fazla olduğu saptandı. Erkeklerde sağ
serebral yarıkürelerin volümü, sağ ve sol frontal ve temporal lobların
hacimlerinde sol tarafta göre daha çok atrofi olduğu, kadınlarda ise sağ
frontal lob hacminin, sol frontal lob hacminden daha çok azaldığı görüldü.

Sonuç: Sonuç olarak yaşlanma ile
beyin volümünde her iki cinsde erkeklerde daha fazla olmak üzere azalma
saptandı. Erkeklerde volüm kaybının daha fazla olmasında gonodal hormonların
etkisi olabileceği düşünüldü.

Anahtar Kelimeler

Yaşlanma, beyin, MRG

Examination of Age Related Volume Changes in Brain by Magnetic Resonance Imaging Method

Öz

Aim: Normal brain aging is
accompanied by cognitive decline. Determination of age-related changes in the
brain helps in understanding the healthy aging process. Our aim was to examine
the volume changes occurring due to advanced age by investigating the age-related
changes in brain during normal aging process.

Method: This study was carried out on
the magnetic resonance (MR) images of 29 healthy subjects consisting of 13
males and 16 females between the ages of 20 to 80. Volumes of right and left
cerebral hemispheres, right and left frontal lobes, and right and left temporal
lobes were measured by Cavalieri sections method on MR images.

Findings: A significant age-related
decline in the volumes of all investigated regions (p<0.05) was observed.
The decline in volume is higher in males in comparison to females.
Additionally, it has been observed that in male subjects, the volume of right
hemisphere, right frontal lobe and right temporal lobe showed more signs of
atrophy than left side; whereas in females, the volume of right frontal lobe
showed a more prominent decline than its left frontal lobe.

Conclusion: An age-related decline in
brain volume has been detected for both sexes; however male subjects suffered a
more prominent decline than females. We believe that the reason behind this
more significant decline might be the effect of gonodal hormones.

Anahtar Kelimeler

Aging, brain, MRI

Kaynakça

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