The effect of ATP-binding cassette (ABC) transporters in human cancers

Yıl 2019, Cilt: 1 Sayı: 1, 14 - 19, 19.08.2019

Seda Mesci , Sevgi Marakli , Burak Yazgan , Tuba Yıldırım

https://doi.org/10.38058/ijsl.594000

Cited By: 2

Öz

Multi-drug resistance (MDR) can be defined
as a negative effect on the drug-target relationships, decreasing in intracellular
drug aggregation. ABC (ATP-binding cassette) are popular transporter proteins in
the development of MDR. ABC proteins in the cell membrane structure reduce the
therapeutic efficacy and cause drug resistance in cancer patients. Resistance
to chemotherapy is a remarkable and important issue in the treatment of cancer
patients. These drug resistance proteins interfere with the drugs administered
to patients, resulting in a decrease in bioavailability of these drugs and a
reduction in their passage through the blood-brain barrier. ABC transporters
are the largest family of transmembrane proteins with 8 subfamilies assigned
from A to G based on sequence and structural homology. In this review, general
information about ABC proteins is mentioned and the role of ABC proteins causing
MDR in cancers is also discussed. 

Anahtar Kelimeler

ABC transporters, Multi-Drug Resistance, Cancer Treatment

Kaynakça

• Baral, B. 2017. Evolutionary trajectories of entomopathogenic fungi ABC transporters, Adv Genet, 98: 117-154.
• Boumendjel, A., Boutonnat, J., Robert, J., 2009. ABC transporters and multidrug resistance. John Wiley & Sons Inc, Hoboken, New Jersey.
• Cole, S.P., Deeley, G.R., 1998. Multidrug resistance mediated by the ATP‐binding cassette transporter protein MRP, Bioessays, 20 (11):931-940.
• Cort, A., Ozben, T., Saso, L., De Luca, C., Korkina, L. 2016. Redox control of multidrug resistance and its possible modulation by antioxidants, Oxidative Medicine and Cellular Longevity, http://dx.doi.org/10.1155/2016/4251912
• Dean, M., Rzhetsky, A., Allikmets, R. 2001. The human ATP-binding cassette (ABC) transporter superfamily, Genome Research, 11(7):1156-1166.
• Domenichini, A., Adamska, A., Falasca, M. 2019. ABC transporters as cancer drivers, potential functions in cancer development, Biochim Biophys Acta Gen Subj, 1863(1): 52-60.
• Flanagan, J.U., Huber, T. 2007. Structural evolution of the ABC transporter subfamily B, Evolutionary Bioinformatics, 3: 309–316.
• Gupta, P., Zhang, Y. K., Zhang, X. Y., Wang, Y. J., Lu, K. W.,et al. Hall, T., 2018. Voruciclib, a potent CDK4/6 inhibitor, antagonizes ABCB1 and ABCG2-mediated multi-Drug resistance in cancer cells, Cell Physiol Biochem, 45(4): 1515-1528.
• He, Q., Yan, Z., Si, F., Zhou, Y., Fu, W., et al. 2019. ATP-binding cassette (ABC) transporter genes involved in pyrethroid resistance in the malaria vector anopheles sinensis: Genome-wide identification, characteristics, phylogenetics, and expression profile, International Journal of Molecular Sciences, 20(6):1409.
• Housman, G., Byler, S., Heerboth, S., Lapinska, K., Longacre, M., et al. 2014. Drug resistance in cancer, an overview, Cancers, 6(3): 1769-1792.
• Erdamar, H., Hacıevliyagil Kazancı, F., Gök, S. 2014. Membrane biochemical changes in cancer, Journal of Clinical and Analytical Medicine, 5 (3): 430-438.
• Ishiguro, J., Ito, H., Tsukamoto, M., Iwata, H., Nakagawa, H., & Matsuo, K. et al. 2019. A functional single nucleotide polymorphism in ABCC11, rs17822931, is associated with the risk of breast cancer in Japanese, Carcinogenesis, 40(4): 537-543.
• Ji, J. Z., Tai, T., Huang, B. B., Gu, T. T., Mi, Q. Y., & Xie, H. G., 2018. Mrp3 transports clopidogrel acyl glucuronide from the hepatocytes into blood, Drug Metab Dispos, 46(2): 151-154.
• Juliano, R.L., Ling, V. A. 1976. Surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants, Biochem, Biophys, Acta, 455:152–162.
• Karva, S., 2014. The role of ABC transporters in anticancer drug transport, Turkish Journal of Biology, 38: 800-805.
• Kathawala, R. J., Wang, Y. J., Ashby, C. R., Jr., Chen, Z. S. 2014. Recent advances regarding the role of ABC subfamily C member 10 (ABCC10) in the efflux of antitumor drugs, Chin J Cancer, 33(5): 223-230.
• Lang Z, Wu Y, Pan X, Qu G, Zhang T. 2018. Study of differential gene expression between invasive mul¬tifocal/multicentric and unifocal breast cancer, JBUON, 23(1): 134-142.
• Leonessa F., Clarke, R., 2003. ATP binding cassette transporters and drug resistance in breast cancer, Endocrine-Related Cancer, 10: 43–73.
• Mansoori, B., Mohammadi, A., Davudian, S., Shirjang, S., Baradaran, B. 2017. The different mechanisms of cancer drug resistance: A brief review, Advanced Pharmaceutical Bulletin, 7(3): 339-348.
• Pala Kara, Z., Öztürk, N., Öztürk, D, Okyar, A. 2013. ABC taşıyıcı proteinleri, sirkadiyan ritimler ve cinsiyete bağlı farklılıklar, Marmara Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 3(1):1-13.
• Stavrovskaya, A.A., Stromskaya, T.P., 2008.Transport proteins of the ABC family and multidrug resistance of tumor cells, The Monthly Journal Biochemistry. (Moscow), 73:592-604.
• Sharom, F.J., 2008. ABC multidrug transporters, structure, function and role in chemoresistance, Pharmacogenomics, 9(1):105–127.
• Thoeringer, C. K., Wultsch, T., Shahbazian, A., Painsipp, E., & Holzer, P. 2007. Multidrug-resistance gene 1-type p-glycoprotein (MDR1 p-gp) inhibition by tariquidar impacts on neuroendocrine and behavioral processing of stress, Psychoneuroendocrinology, 32(8-10):1028-1040.