Determination of the antiproliferative effect of Folliculj sennea used as a laxative on CCD-18Co cell line and proliferative effect on DLD-1 and HT- 29 cancer cell lines

Yıl 2022, Cilt: 4 Sayı: 2, 226 - 235, 24.08.2022

Aybüke Afra Keskiner , Berna Kocaman

Öz

The most prominent feature of malnutrition that increases colon cancer is the use of laxatives. Most community-dwelling individuals self-manage the condition of bowel-related diseases and do not seek medical advice. Self-management often involves the use of laxative products that can be purchased over the counter from pharmacies and elsewhere. According to the research, most of those who use herbal products do not get enough information about the products they use, and the most important problem is that they do not inform their health consultants (doctors, pharmacists, dietitians, nurses, etc.) about the product they use. Individuals get information about the product they use from transfers such as uncontrolled media channels on the internet, and they reach the product easily. Long-term use of laxatives is predicted to impair healthy colonic function, produce laxative dependence, and damage the enteric nervous system and/or intestinal smooth muscle. It manages colon motility and may increase the risk of other types of cancer, especially colon cancer. In our study, the antiproliferative effect of Folliculj sennae plant, which is commonly used as a laxative, known as fasting herb, horseradish herb, and camel eye herb and contains an anthracoid laxative, on CCD-18Co (healthy colon epithelium) cell line and DLD-1 (colon cancer) and HT-29 (colorectal cancer) cancer cell lines, on the other hand, aimed to determine its proliferative effect by MTT analysis.

Anahtar Kelimeler

Folliculj sennae, Laxative, MTT, Colon cancer, Cytotoxicity

Kaynakça

• Citronberg, J. S., Hardikar, S., Phipps, A., Figueiredo, J. C. and Newcomb, P. (2018). Laxative type about colorectal cancer risk. Annals of epidemiology, 28(10), 739-741.
• Clinton, S. K., Giovannucci, E. L. and Hursting, S. D. (2020). The world cancer research fund/American institute for cancer research third expert report on diet, nutrition, physical activity, and cancer: impact and future directions. The Journal of nutrition, 150(4), 663-671.
• George, SM, Ballard-Barbash, R., Manson, JE, Reedy, J., Shikany, JM, Subar, AF, ... & Neuhouser, ML (2014). Kadın Sağlığı Girişimi Gözlem Çalışması'nda postmenopozal kadınlarda diyet kalitesi endekslerinin kronik hastalık mortalite riski ile karşılaştırılması: ulusal diyet rehberliğini bilgilendirecek kanıt. Amerikan epidemiyoloji dergisi, 180 (6), 616-625.
• Jakszyn, P., Cayssials, V., Buckland, G., Perez‐Cornago, A., Weiderpass, E., Boeing, H. and Agudo, A. (2020). Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study. International journal of cancer, 147(4), 1027-1039.
• Nusko, G., Schneider, B., Schneider, I., Wittekind, C. and Hahn, E. G. (2000). Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut, 46(5), 651-655.
• Tanaka, T., Nishikawa, A., Shima, H., Sugie, S., Shinoda, T., Yoshimi, N. and Mori, H. (1990). Inhibitory effects of chlorogenic acid, reserpine, polyprenoic acid (E-5166), or coffee on hepatocarcinogenesis in rats and hamsters. In Antimutagenesis and anticarcinogenesis mechanisms II (pp. 429-440).
• Uzun, M. B., Aykaç, G. ve Özçelikay, G. (2014). Bitkisel Ürünlerin Yanlış Kullanımı Ve Zararları.Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, 4(3), 1-5.
• Wei, Z., Wu, J., Yang, Y., Cheng, P., Tao, L., Shan, Y. and Lu, Y. (2020). Anthraquinone laxative-altered gut microbiota induces colonic mucosal barrier dysfunction for colorectal cancer progression.
• Werth, B. L., Williams, K. A., Fisher, M. J. and Pont, L. G. (2020). Use of over-the-counter laxatives by community-dwelling adults to treat and prevent constipation: a national cross-sectional study. European journal of clinical pharmacology, 76(7), 1003-1010.
• Zheng, Y. F., Liu, C. F., Lai, W. F., Xiang, Q., Li, Z. F., Wang, H. and Lin, N. (2014). The laxative effect of emodin is attributable to increased aquaporin 3 expression in the colon of mice and HT-29 cells. Fitoterapia, 96, 25-32.