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A Review: Momordica charantia L.'s Biological Active Components and Its Potential Use in Traditional Therapies

Yıl 2020, Cilt: 1 Sayı: 2, 79 - 95, 27.08.2020

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The use of herbs for therapeutic purposes has been widespread since ancient times. In traditional treatments, plants are applied in a variety of forms, either directly or prepared by isolation and / or enrichment of biologically active ingredients. Momordica charantia L. (bitter melon) is a popular bush that has traditional use as a supplement in the treatment of various diseases with its rich bioactive ingredient content. The plant has common pharmacological potential, including antimicrobial, antimutagenic, antifertility, antidiabetic, antioxidant, antilipolytic, hypoglycemic, anticancer, antimicrobial, antiviral and hepatoprotective activities. This review provides a short overview of the in vitro, in vivo and clinical studies conducted to evaluate the therapeutic efficacy and safety of Momordica charantia.

Kaynakça

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Yıl 2020, Cilt: 1 Sayı: 2, 79 - 95, 27.08.2020

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Kaynakça

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  • Huang X, Nie S. The structure of mushroom polysaccharides and their beneficial role in health. Food & function. 2015;6(10):3205-3217.
  • Wu J, Zhou J, Lang Y, Yao L, Xu H, Shi H, Xu S. A polysaccharide from Armillaria mellea exhibits strong in vitro anticancer activity via apoptosis-involved mechanisms. International journal of biological macromolecules. 2012;51(4):663-667.
  • LI Z-t, ZHANG J, XIE J, SUN R-g. The inhibition effect of two different M. charantia polysaccharides on the proliferation of human leukemia cell in vitro. Journal of Shaanxi Normal University (Natural Science Edition). 2013;2.
  • Guan L. Synthesis and anti-tumour activities of sulphated polysaccharide obtained from M. charantia. Natural product research. 2012;26(14):1303-1309.
  • Yue J, Sun Y, Xu J, Cao J, Chen G, Zhang H, Zhang X, Zhao Y. Cucurbitane triterpenoids from the fruit of M. charantia L. and their anti-hepatic fibrosis and anti-hepatoma activities. Phytochemistry. 2019;157:21-27.
  • Somasagara RR, Deep G, Shrotriya S, Patel M, Agarwal C, Agarwal R. Bitter melon juice targets molecular mechanisms underlying gemcitabine resistance in pancreatic cancer cells. International journal of oncology. 2015;46(4):1849-1857.
  • Dhar D, Deep G, Kumar S, Wempe MF, Raina K, Agarwal C, Agarwal R. Bitter melon juice exerts its efficacy against pancreatic cancer via targeting both bulk and cancer stem cells. Molecular carcinogenesis. 2018;57(9):1166-1180.
  • Wang Y-X, Jacob J, Wingfield PT, Palmer I, Stahl SJ, Kaufman JD, Huang PL, Huang PL, Lee-Huang S, Torchia DA. Anti-HIV and anti-tumor protein MAP30, a 30 kDa single-strand type-I RIP, shares similar secondary structure and β-sheet topology with the A chain of ricin, a type-II RIP. Protein Science. 2000;9(1):138-144.
  • Ping-ping Z, Jin-fu L, Chang-lu W, Yan-ting Y, Jin-hai X. Study on the Antimicrobial Activities of the Extracts from M. charantia L. Natural Product Research & Development. 2008;20(4).
  • Fang EF, Zhang CZY, Fong WP, Ng TB. RNase MC2: a new M. charantia ribonuclease that induces apoptosis in breast cancer cells associated with activation of MAPKs and induction of caspase pathways. Apoptosis. 2012;17(4):377-387.
  • Fang EF, Zhang CZY, Ng TB, Wong JH, Pan WL, Ye XJ, Chan YS, Fong WP. M. charantia lectin, a type II ribosome inactivating protein, exhibits antitumor activity toward human nasopharyngeal carcinoma cells in vitro and in vivo. Cancer Prevention Research. 2012;5(1):109-121.
  • Pitchakarn P, Suzuki S, Ogawa K, Pompimon W, Takahashi S, Asamoto M, Limtrakul P, Shirai T. Kuguacin J, a triterpeniod from M. charantia leaf, modulates the progression of androgen-independent human prostate cancer cell line, PC3. Food and chemical toxicology. 2012;50(3-4):840-847.
  • Shim SH, Sur S, Steele R, Albert CJ, Huang C, Ford DA, Ray RB. Disrupting cholesterol esterification by bitter melon suppresses triple‐negative breast cancer cell growth. Molecular carcinogenesis. 2018;57(11):1599-1607.
  • Duan Z-Z, Zhou X-L, Li Y-H, Zhang F, Li F-Y, Su-Hua Q. Protection of M. charantia polysaccharide against intracerebral hemorrhage-induced brain injury through JNK3 signaling pathway. Journal of Receptors and Signal Transduction. 2015;35(6):523-529.
  • Gong J, Sun F, Li Y, Zhou X, Duan Z, Duan F, Zhao L, Chen H, Qi S, Shen J. M. charantia polysaccharides could protect against cerebral ischemia/reperfusion injury through inhibiting oxidative stress mediated c-Jun N-terminal kinase 3 signaling pathway. Neuropharmacology. 2015;91:123-134.
  • Perveen H, Dey A, Nilavar NM, Chandra GK, Islam SS, Chattopadhyay S. Dietary CCPS from bitter gourd attenuates sodium arsenite induced female reproductive ailments cum infertility in wistar rats: anti-inflammatory and anti-apoptotic role. Food and Chemical Toxicology. 2019;131:110545.
  • Hulin A, Wavelet M, Desbordes J. Intoxication aiguë par M. charantia (Sorrossi)(à propos de deux cas). Médecine d'Afrique Noire. 1988;35(9):671-674.
  • Tennekoon KH, Jeevathayaparan S, Angunawala P, Karunanayake EH, Jayasinghe K. Effect of M. charantia on key hepatic enzymes. Journal of ethnopharmacology. 1994;44(2):93-97.
  • Dutta P, Chakravarty A, Chowdhury U, Pakrashi S. Studies on Indian Medicinal-Plants. 64. Vicine, A Favism-Inducing Toxin From Momordica-Charantia Linn Seeds. Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry. 1981;20(8):669-671.
  • Aguwa C, Mittal G. Abortifacient effects of the roots of Momordica angustisepala. Journal of ethnopharmacology. 1983;7(2):169-173.
  • Chan W, Tam P, Yeung H. The termination of early pregnancy in the mouse by β-momorcharin. Contraception. 1984;29(1):91-100.
  • Leung S, Yeung H, Leung K. The immunosuppressive activities of two abortifacient proteins isolated from the seeds of bitter melon (M. charantia). Immunopharmacology. 1987;13(3):159-171.
  • Stepka W, Wilson K, Madge G. Antifertility investigation on Momordica. Lloydia. 1974;37(4):645c.
  • Dixit V, Khanna P, Bhargava S. Effects of M. charantia L. fruit extract on the testicular function of dog. Planta medica. 1978;34(07):280-286.
  • Schreiber CA, Wan L, Sun Y, Lu L, Krey LC, Lee-Huang S. The antiviral agents, MAP30 and GAP31, are not toxic to human spermatozoa and may be useful in preventing the sexual transmission of human immunodeficiency virus type 1. Fertility and sterility. 1999;72(4):686-690.
  • Khan MF, Abutaha N, Nasr FA, Alqahtani AS, Noman OM, Wadaan MA. Bitter gourd (M. charantia) possess developmental toxicity as revealed by screening the seeds and fruit extracts in zebrafish embryos. BMC complementary and alternative medicine. 2019;19(1):1-13.
  • Beniwal P, Gaur N, Singh S, Raveendran N, Malhotra V. How harmful can herbal remedies be? A case of severe acute tubulointerstitial nephritis. Indian journal of nephrology. 2017;27(6):459.
  • Mardani S, Nasri H, Hajian S, Ahmadi A, Kazemi R, Rafieian-Kopaei M. Impact of M. charantia extract on kidney function and structure in mice. Journal of nephropathology. 2014;3(1):35.
  • Marles RJ, Farnsworth NR. Antidiabetic plants and their active constituents. Phytomedicine. 1995;2(2):137-189.
  • Aslam M, Stockley I. Interaction between curry ingredient (karela) and drug (chlorpropamide). The Lancet. 1979;313(8116):607.
  • Akter S, Goto A, Mizoue T. Smoking and the risk of type 2 diabetes in Japan: a systematic review and meta-analysis. Journal of epidemiology. 2017;27(12):553-561.
Toplam 138 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Geleneksel, Tamamlayıcı ve Bütünleştirici Tıp
Bölüm Derlemeler
Yazarlar

Gülşah Aydın 0000-0002-5376-0690

Ertuğrul Kaya 0000-0003-0081-682X

Yayımlanma Tarihi 27 Ağustos 2020
Gönderilme Tarihi 27 Mayıs 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 1 Sayı: 2

Kaynak Göster

APA Aydın, G., & Kaya, E. (2020). A Review: Momordica charantia L.’s Biological Active Components and Its Potential Use in Traditional Therapies. International Journal of Traditional and Complementary Medicine Research, 1(2), 79-95.

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