KLİNİĞİMİZDE TANI KONULAN GÖZ VE ADNEKSLERİNİN PREMALİGN VE MALİGN LEZYONLARININ KLİNİK VE HİSTOPATOLOJİK ANALİZİ

Yıl 2023, Cilt: 11 Sayı: 1, 1081 - 1091, 17.03.2023

Seyhan Dikci , Ayşe Nur Akatlı

https://doi.org/10.33715/inonusaglik.1219766

Öz

Amacımız üçüncü basamak bir klinikte tanı konulan göz ve adnekslerinin premalign ve malign lezyonlarının klinikopatolojik analizini yapmaktır. Mart 2010 – Temmuz 2020 tarihleri arasında İnönü Üniversitesi Tıp Fakültesi Göz Hastalıkları Anabilim Dalı’nda ameliyat edilen ve patoloji laboratuvarına spesmen gönderilen hastaların dosyaları retrospektif olarak incelendi. Premalign ve malign lezyonu olan olguların demografik, klinik ve histopatolojik verileri kaydedildi. 64’ü kadın (%47.1), 72’si (%52.9) erkek toplam 136 hasta çalışmaya dahil edildi. Hastaların ortalama yaşı 73.6±14.7 (11-101) yıldı. 58 (%42.6) hastada premalign, 78 (%57.4) hastada malign lezyon tespit edildi. En sık rastlanan premalign lezyonlar konjonktival ya da korneal intraepitelyal neoplazi, karsinoma in situ iken, en sık rastlanan malign lezyonlar bazal hücreli karsinom, skuamöz hücreli karsinom ve lenfomaydı. Kliniğimizde en sık tanı konulan göz ve adnekslerinin premalign lezyonu konjonktival/korneal intraepitelyal neoplazi, malign lezyonu ise bazal hücreli karsinom olarak tespit edilmiştir.

Anahtar Kelimeler

Bazal hücreli karsinom, Göz, Karsinoma in situ, Konjonktival intraepitelyal neoplazi, Skuamöz hücreli karsinom.

Destekleyen Kurum

Yok

Proje Numarası

Yok

Teşekkür

Yok

Clinical and Histopathological Analysis of Premalignant and Malignant Lesions of Eyes and Adnexes Diagnosed in Our Clinic

Öz

Our aim is to perform clinicopathological analysis of premalignant and malignant lesions of the eye and adnexa diagnosed in a tertiary clinic. The files of the patients who underwent surgery and sent specimens to pathology laboratory at Inönü University Faculty of Medicine, Department of Ophthalmology between March 2010 and July 2020 were reviewed retrospectively. Demographic, clinical and histopathological data of cases with premalignant and malignant lesions were recorded. A total of 136 patients, 64 (47.1%) female and 72 (52.9%) male, were included in the study. The mean age of the patients was 73.6±14.7 (11-101) years. Premalignant lesions were detected in 58 patients (42.6%) and malignant lesions were detected in 78 patients (57.4%). The most common premalignant lesions were conjunctival or corneal intraepithelial neoplasia, carcinoma in situ, while the most common malignant lesions were basal cell carcinoma, squamous cell carcinoma, and lymphoma. In our clinic, the most commonly diagnosed premalignant lesion of the eyes and adnexa was conjunctival intraepithelial neoplasia, and the malignant lesion was basal cell carcinoma.

Anahtar Kelimeler

Basal cell carcinoma, Carcinoma in situ, Conjunctival intraepithelial neoplasia, Eye, Squamous cell carcinoma.

Proje Numarası

Yok

Kaynakça

• Alrobaian, M. A. ve Henderson A. D. (2021). Neuro-Ophthalmic manifestations of acute leukemia. J Neuroophthalmol, 41(4), 584-e590.
• Arepalli, S., Kaliki, S. ve Shields, C. L. (2015). Choroidal metastases: origin, features, and therapy. Indian J Ophthalmol, 63(2), 122-127.
• Avram, A. M., Gielczyk, R., Su, L., Vine, A. K. ve Sisson, J. C. (2014). Choroidal and skin metastases from papillary thyroid cancer: Case and a review of the literature. J Clin Endocrinol Metab., 9, 5303–5307.
• Besic, N. ve Luznik, Z. (2013). Choroidal and orbital metastases from thyroid cancer. Thyroid., 23, 543–551.
• Ceylan, O. M., Uysal, Y., Erduman, F. C., Gültekin, K., Durukan, A. H., …Köksal, S. (2010) Clinical and histopathological analysis of conjunctival tumors. Gülhane Tıp Derg., 52, 248-251.
• Delestre, F., Blanche, P., Bouayed, E., Bouscary, D., Mouthon, L., Brezin, A., Le Jeunne, C. ve Chaigne, B. (2021) Ophthalmic involvement of chronic lymphocytic leukemia: A systematic review of 123 cases. Surv Ophthalmol, 66(1), 124-131.
• Fasina O. (2021) Ocular surface squamous neoplasia at a tertiary eye facility, Southwestern Nigeria: A 10-year review. Int Ophthalmol, 41(10), 3325-3331.
• Finger, P. T. (2015). Ocular malignancies: Choroidal melanoma, retinoblastoma, ocular adnexal lymphoma and eyelid cancer. B. O’Sullivan ve S. H. Huang (Eds.), UICC manual of clinical oncology içinde (ss. 726–745). West Sussex: Wiley.
• Gurnani, B. ve Kaur, K. (2022). Ocular Surface Squamous Neoplasia. [Updated 2022 Aug 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK573082/
• Hossain, R. R. ve McKelvie, J. (2022). Ocular surface squamous neoplasia in New Zealand: a ten-year review of incidence in the Waikato region. Eye (Lond)., 36(8), 1567-1570.
• Hӧllhumer, R., Williams, S. ve Michelow, P. (2021). Ocular surface squamous neoplasia: management and outcomes. Eye (Lond)., 35(6), 1562-1573.
• Kale, S. M., Patil, S. B., Khare, N., Math, M., Jain, A. ve Jaiswal, S. (2012) Clinicopathological analysis of eyelid malignancies-A review of 85 cases. Indian J Plast Surg., 45, 22-28.
• Katırcıoğlu, Y. A. (2014). Malign Göz Kapağı Tümörlerinin Tedavisinde Yenilikler. Turk J Ophthalmol, 44, Supplement 55-60.
• Kirkegaard, M. M., Coupland, S. E., Prause, J. U. ve Heegaard, S. (2015). Malignant lymphoma of the conjunctiva. Surv Ophthalmol, 60, 444‒458.
• Krishna, Y. ve Coupland, S. E. (2017). Lacrimal sac tumors-a review. Asia Pac J Ophthalmol, 6(2), 173-178.
• Lee, G. A. ve Hirst, L. W. (1992). Incidence of ocular surface epithelial dysplasia in metropolitan Brisbane. A 10-year survey. Arch Ophthalmol. 110(4), 525-527.
• Lee, G. A. ve Hirst, L. W. (1995). Ocular surface squamous neoplasia. Surv Ophthalmol, 39(6), 429–450.
• Maheshwari, A. ve Finger, P. T.(2018). Cancers of the eye. Cancer Metastasis Rev., 37(4), 677-690.
• Margo, C. E. ve Waltz, K. (1993). Basal cell carcinoma of the eyelid and periocular skin. Surv Ophthalmol, 38(2), 169–192.
• Moloney, T. P., Trinh, T. ve Farrah, J. J. (2014). A case of conjunctival mucoepidermoid carcinoma in Australia. Clin Ophthalmol, 8, 11-14.
• Özkan, A., Pazarlı, H., Karaman, S., Celkan, T., Apak, H., …Özkan, F. (2006). Gözde kitle nedeni ile başvuran hastalarımızın geriye dönük olarak dökümü: 1985- 2004. Türk Pediatri Arşivi, 41, 41- 45.
• Pizzarello, L. D. ve Jakobiec, F. A. (1978). Bowen’s disease of the conjunctiva: A misnomer. Jakobiec, F. A. (Ed.). Ocular ve Adnexal Tumors. Birmingham, AL: Aesculapius içinde (ss. 553–71).
• Savino, G., Cuffaro, G., Maceroni, M., Pagliara, M. M., Sammarco, M. G., Giraldi, L. ve Blasi, M. A. (2021). Advanced ocular surface squamous cell carcinoma (OSSC): Long-term follow-up. Graefes Arch Clin Exp Ophthalmol, 259(11), 3437-3443.
• Shields, C. L., Shields, J. A., Gross, N. E., Schwartz, G. P. ve Lally, S. E. (1997). Survey of 520 eyes with uveal metastases. Ophthalmology,104, 1265–1276.
• Sjo, L. D., Ralfkiaer, E., Prause, J. U., Petersen, J. H., Madsen, J., …Pedersen, N. T. (2008). Increasing incidence of ophthalmic lymphoma in Denmark from 1980 to 2005. Invest Ophthalmol Vis Sci., 49, 3283‒3288.
• Singh, A. D., Bergman, L. ve Seregard, S. (2005). Uveal melanoma: epidemiologic aspects. Ophthalmology Clinics of North America, 18(1), 75–84 viii.
• Tarlan, B. ve Kıratlı, H. (2016). Uvea melanomu; Tanı ve tedavide güncel yaklaşımlar. Turk J Ophthalmol, 46, 123-137.
• Turbiner Geyer, J. ve Knowles, D. M. (2013). Malignant lymphomas and lymphoid hyperplasias that occur in the ocular adnexa (orbit, conjunctiva and eyelids). Knowles D. M. (Ed.). Neoplastic Hematopathology içinde (s. 1304). Philadelphia: Lippincott Williams & Wilkins..
• Uysal, Y. (2008). Göz kapağının benign-malign tümörleri. Türk Oftal Dern Eği Yayın no:6. Temel Oküler Onkoloji, 17-56.
• Verdijk, R. M., Pecorella, I. ve Mooy, C. (2015). The orbit, including the lacrimal gland and lacrimal drainage system. Heegaard, S., Grossniklaus, H. E. (Ed.). Eye Pathology: An Illustrated Guide içinde (ss. 547-732). Berlin: Springer-Verlag.
• Williams, B. K. ve Jr, Di Nicola, M. (2021). Ocular oncology-primary and metastatic malignancies. Med Clin North Am., 105(3), 531-550.
• Zhang, K. Y., Aurit, S. ve Silberstein, P. (2022). Racial and socioeconomic disparities in ocular surface squamous neoplasia: A National Cancer Database analysis. Ophthalmic Epidemiol, 29(3), 319-327.