Öz
Pyoderma gangrenosum (PG) is a serious skin lesion which may accompanying numerous diseases and it can cause of painful, and recurrent ulcer. The lesions may arise as single or multiple lesions secondary to systemic diseases such as ulcerative colitis, Crohn’s disease, polyarthritis, monoclonal gammopathy or spontaneously without any underlying disease. A 25-year-old male patient was admitted with complaints of fever, abdominal pain, bloody diarrhea, painful and infected deep ulcers on head, trunk and extremities. Rectosigmoidoscopy was performed eight days ago and biopsies on sigmoid colon mucosa from the ulcerated lesions were taken because of suspected from ulcerative colitis (UC). Mesalazine and fluocortolone was initiated with diagnosis of UC and PG. Complaints of patient and colonic and skin lesions rapidly regressed. An amputation of his right foot’s on 3rd finger and skin graft operations for skin defects on his right arm and right leg was performed three months later. He was discharged from the hospital with improved symptoms. Here, we aimed to emphasis the importance of PG in differential diagnosis in patients who was admitted to hospital with skin abscess and skin ulcers which seem like to be infected
Anahtar Kelimeler
Kaynakça
- von den Driesch P. Pyoderma gangrenosum: a report of 44 cases with follow-up. Br J Dermatol. 1997 Dec;137(6):1000-5.
- Binus AM, Qureshi AA, Li VW, Winterfield LS. Pyoderma gangrenosum: a retrospective review of patient characteristics, comorbidities and therapy in 103 patients. Br J Dermatol. 2011;165(6):1244.
- Farhi D, Cosnes J, Zizi N, Chosidow O, Seksik P, Beaugerie L, Aractingi S, Khosrotehrani K. Significance of erythema nodosum and pyoderma gangrenosum in inflammatory bowel diseases: a cohort study of 2402 patients. Medicine (Baltimore). 2008 Sep;87(5):281-93.
- Ahronowitz I, Harp J, Shinkai K. Etiology and management of pyoderma gangrenosum: a comprehensive review. Am J Clin Dermatol. 2012;13(3):191.
- Bennett ML, Jackson JM, Jorizzo JL, Fleischer AB Jr, White WL, Callen JP. Pyoderma gangrenosum. A comparison of typical and atypical forms with an emphasis on time to remission. Case review of 86 patients from 2 institutions. Medicine (Baltimore). 2000;79(1):37.
- Ahmadi S, Powell FC. Pyoderma gangrenosum: uncommon presentations. Clin Dermatol 2005; 23: 612-20.
- Abdelrazeq AS, Lund JN, Leveson SH. Pouchitis-associated pyoderma gangrenosum following restorative proctocolectomy for ulcerative colitis. Eur J Gastroenterol Hepatol 2004; 16: 1057-8.
- Abela CB1, Soldin M, Gateley D. Pyoderma gangrenosum--case report. Br J Oral Maxillofac Surg. 2007 Jun;45(4):328-30.
- Futami H, Kodaira M, Furuta T, Hanai H, Kaneko E. Pyoderma gangrenosum complicating ulcerative colitis: successful treatment with methylprednisolone pulse therapy and cyclosporine. J Gastroenterol 1998; 33: 408-11.
Öz
Pyoderma gangrenozum (PG), çok çeşitli hastalıklarla birlikte olabilen, ağrılı ve rekürren derin ülserasyonlarla seyredebilen ciddi bir deri
lezyonudur. Lezyonlar, ülseratif kolit, Crohn hastalığı, poliartrit, monoklonal gammopati gibi sistemik hastalıklarla birlikte veya altta yatan
bir hastalık olmaksızın tek veya çok sayıda görülebilirler. 25 yaşında erkek hasta, ateş, karın ağrısı, kanlı ishal ve alında, gövde ve
ekstremitelerde yaygın ağrılı, enfekte ve derin ülserlerle başvurdu. Hastaya 8 gün önce rektosigmoidoskopi yapılmıştı ve ülseratif kolitten
(ÜK) şüphelenilmişti ve sigmoid kolondaki ülsere lezyonlardan biyopsi alınmıştı. Hastaya ÜK ve PG teşhisiyle mesalazine ve fluocortolone
başlandı. Hastanın şikayetleri, barsak ve deri lezyonları hızla geriledi. 3 ay sonra sağ ayak 3. parmağa amputasyon ve sağ koldaki ve sağ
bacaktaki cilt defektleri için greft operasyonu yapıldı. Hasta şifa ile taburcu edildi. Biz bu vakayı, apse ve infekte görünümlü deri ülserleriyle
gelen hastada PG’nin, ayırıcı tanıdaki yerini vurgulamak amacıyla rapor ettik
Anahtar Kelimeler
Fluocortolone mesalazin pyoderma gangrenozum ülseratif kolit
Kaynakça
- von den Driesch P. Pyoderma gangrenosum: a report of 44 cases with follow-up. Br J Dermatol. 1997 Dec;137(6):1000-5.
- Binus AM, Qureshi AA, Li VW, Winterfield LS. Pyoderma gangrenosum: a retrospective review of patient characteristics, comorbidities and therapy in 103 patients. Br J Dermatol. 2011;165(6):1244.
- Farhi D, Cosnes J, Zizi N, Chosidow O, Seksik P, Beaugerie L, Aractingi S, Khosrotehrani K. Significance of erythema nodosum and pyoderma gangrenosum in inflammatory bowel diseases: a cohort study of 2402 patients. Medicine (Baltimore). 2008 Sep;87(5):281-93.
- Ahronowitz I, Harp J, Shinkai K. Etiology and management of pyoderma gangrenosum: a comprehensive review. Am J Clin Dermatol. 2012;13(3):191.
- Bennett ML, Jackson JM, Jorizzo JL, Fleischer AB Jr, White WL, Callen JP. Pyoderma gangrenosum. A comparison of typical and atypical forms with an emphasis on time to remission. Case review of 86 patients from 2 institutions. Medicine (Baltimore). 2000;79(1):37.
- Ahmadi S, Powell FC. Pyoderma gangrenosum: uncommon presentations. Clin Dermatol 2005; 23: 612-20.
- Abdelrazeq AS, Lund JN, Leveson SH. Pouchitis-associated pyoderma gangrenosum following restorative proctocolectomy for ulcerative colitis. Eur J Gastroenterol Hepatol 2004; 16: 1057-8.
- Abela CB1, Soldin M, Gateley D. Pyoderma gangrenosum--case report. Br J Oral Maxillofac Surg. 2007 Jun;45(4):328-30.
- Futami H, Kodaira M, Furuta T, Hanai H, Kaneko E. Pyoderma gangrenosum complicating ulcerative colitis: successful treatment with methylprednisolone pulse therapy and cyclosporine. J Gastroenterol 1998; 33: 408-11.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 9 Haziran 2015 |
| Yayımlandığı Sayı | Yıl 2015 Cilt: 1 Sayı: 4 |