Tedavinin Sirolimus’tan Everolimus’a değiştirilmesi sonucu Everolimus’a bağlı pnömonit gelişen bir böbrek transplantasyonu hastası olgusu

Yıl 2019, Cilt: 43 Sayı: 1, 37 - 39, 01.07.2019

Eda Kaya Alican Karakoç Mehmet Velidedeoğlu Salih Pekmezci Sinan Trabulus Nurhan Seyahi

Öz

DOI: 10.26650/cjm.2019.43.33 

Pnömonit
mammalian target of rapamycin inhibitörleri tedavisinde görülen bir yan
etkidir. Biz bu olguda tedavinin sirolimustan everolimusa değiştirilmesi sonucu
everolimusa bağlı pnömonit gelişen bir hastayı sunuyoruz. 33 yaşında kadın
hasta tedavisinin sirolimustan everolimusa değiştirilmesinden sonra gelişen
kliniğimize halsizlik, öksürük, gece terlemesi ve yüksek ateş şikayetleriyle
başvurdu. Toraks BT’de buzlu cam görüntüsü ve asiner nodüller görüldü.
Everolimus tedavisi kesildikten sonra hastanın şikayetleri tamamen geriledi.
Sirolimustan everolimusa geçiş sonucu pnömonit daha önce gözlemlenmemiştir.
Everolimus alan hastalarda pulmoner semptomlar gelişirse everolimusa bağlı
pnömonit düşünülmelidir.

Cite this article as: Kaya E, Karakoç A,
Velidedeoğlu M, Pekmezci S, Trabulus S, Seyahi N. A Case of Everolimus Related
Pneumonitis Occurred After Switching Treatment from Sirolimus in a Kidney
Transplant Patient. Cerrahpasa Med J 2019; 43(1): 37-39.

Anahtar Kelimeler

Everolimus, Sirolimus, m-TOR inhibitörleri, ilaca bağlı pnömonit, böbrek transplantasyonu

A Case of Everolimus Related Pneumonitis Occurred After Switching Treatment from Sirolimus in a Kidney Transplant Patient

Öz

DOI: 10.26650/cjm.2019.43.33 

Pneumonitis is a reported side effect of
treatment with mammalian target of rapamycin inhibitors. In this report, we
present a case of everolimus-related pneumonitis that occurred after treatment
switching from sirolimus to everolimus. A 33-year-old female was admitted to
our clinic with fatigue, cough, night sweats, and high fever after treatment
switching from sirolimus to everolimus. Thorax CT revealed ground-glass
densities and acinar nodules. After withdrawal of everolimus, complete
remission was observed. Pneumonitis after treatment switching from sirolimus to
everolimus has not been observed before. In patients with pulmonary symptoms
during everolimus treatment, drug-related pneumonitis should be considered. 

Cite this article as: Kaya E, Karakoç A,
Velidedeoğlu M, Pekmezci S, Trabulus S, Seyahi N. A Case of Everolimus Related
Pneumonitis Occurred After Switching Treatment from Sirolimus in a Kidney
Transplant Patient. Cerrahpasa Med J 2019; 43(1): 37-39.

Anahtar Kelimeler

Everolimus, sirolimus, mTOR inhibitors, drug-related pneumonitis, kidney transplantation

Kaynakça

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