Nöronal Plastisite ve Nörodejeneratif Hastalıklarda NF-κB’nin Rolü

Yıl 2017, Cilt: 7 Sayı: 13, 71 - 85, 01.06.2017

Elif Nuran Yağmur Nazım Yıldız Serkan Adıgüzel Banu Femir Seray Şenyer Melis Şen Erdem Tüzün , Cem İsmail Küçükali

Öz

NF-κB yirminci yüzyılın sonlarında açığa çıkarılmış bir transkripsiyon faktörüdür. Başlarda immün

hücrelerde varlığı gösterilirken ilerleyen çalışmalarda organizmadaki hemen hemen bütün hücrelerde

mevcut bulunduğu ortaya konulmuştur. 500’e yakın genin aktivasyonunda yer alan NF-κB immün cevap

süreci, hücre döngüsü, sağkalımı, proliferasyonu ve gelişiminin yanı sıra plastisite ve bellek oluşumu

gibi mekanizmalarda da etkinlik göstermektedir. Merkezi sinir sisteminde (MSS) NF-κB uzun

süreli potansiyasyon (long-term potentiation-LTP) sağlanmasında etkinliği ile plastisiteyi ve

dolayısıyla bellek oluşumunu etkilemektedir. Bunlara ek olarak, nörodejenerasyonun üzerinde

inflamasyonun etkisinin önemine dair çalışmalar son yıllarda artış göstermiştir. İnflamasyonun kilit

mekanizmalarının bazılarında NF-κB merkezi rol oynamaktadır. Çalışmamızda plastisite ve bellek

oluşum mekanizmalarına ek olarak, nörodejeneratif seyir izleyen Huntington hastalığı (HH),

Parkinson hastalığı (PH), Alzheimer hastalığı (AH) ve Multiple Skleroz (MS) hastalıklarının

patogenezinde NF-κB’nin etkileri incelenmiştir. Nöronal plastisite ve belirtilen hastalıkların

mekanizması ve patogenezinin NF-κB ile olan ilişkisine dair literatürdeki veriler taranmış ve

toparlanmıştır.

Anahtar Kelimeler

NF-κB, nöronal plastisite, Nörodejeneratif hastalıklar

THE ROLE OF NF-κB IN NEURONAL PLASTICITY AND NEURODEGENERATIVE DISEASES

Öz

NF-κB is a transcription factor emerged by the end of 20th century. At the beginning, NF-κB was

found to be present in immune cells but following studies showed its presence in almost all cells in

an organism. NF-κB takes part in the activation of almost 500 genes and have roles in mechanisms

including immune response, cell cycle, cell survival, cell proliferation and development, as well as

plasticity and memory formation. Long-term potentiation (LTP) of NF-κB in the central nervous

system (CNS) affects plasticity, hence memory formation. In addition to these, studies on the effects of

inflammation on neurodegeneration showed an increase in the last years. NF-κB plays a role in some

of the crucial inflammation mechanisms. In the current study, we investigated the effect of NF-κB in

pathogenesis of neurodegenerative diseases including Huntington’s Disease (HD), Parkinson’s Disease

(PD), Alzheimer’s Disease (AD) and Multiple Sclerosis (MS) in addition to the plasticity and memory

formation mechanisms. Studies in the literature on the relationship of NF-κB with neuronal plasticity,

mechanisms of diseases above and pathogenesis were scanned and collected.

Anahtar Kelimeler

NF-κB, neuronal plasticity, neurodegenerative diseases

Kaynakça

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