Ceragenins exhibiting promising antimicrobial activity against various multidrug resistant Gram negative bacteria

Yıl 2018, Cilt: 48 Sayı: 3, 68 - 72, 01.12.2018

Özlem Oyardı , Paul B. Savage Alper Akçalı , Zayre Erturan , Çağla Bozkurt-güzel

Öz

DOI: 10.26650/IstanbulJPharm.2018.400730

Ceragenins are novel promising agents for
the treatment of infections caused by multi-drug resistant microorganisms.
Since colistin resistance has become a worldwide problem, the need for new
treatment agents has been increasing steadily. Therefore, this study aimed to
investigate in vitro antimicrobial activities of ceragenins (Cationic Steroid
Antibiotics) (CSA-8, CSA-13, CSA-142 and CSA-192) against multidrug resistant
Gram negative isolates from Turkey. Experiments were performed by using broth
microdilution method against Klebsiella pneumoniae, Morganella morganii,
Pseudomonas aeruginosa and Stenotrophomonas maltophilia isolates. All
microorganisms except for three isolates were identified as multidrug
resistant. Among tested ceragenins, CSA-13 showed the best results (MIC: 8-64
µg/ml). Nevertheless, the antimicrobial activity of CSA-8 was not significant.
In conclusion, ceragenins appear to be a good candidate as antimicrobial
therapy in the presence of multidrug (including colistin) resistant
microorganisms.

Anahtar Kelimeler

Ceragenins, colistin resistance, gram negative pathogens

Kaynakça

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