A smarter, tactical approach for combating Covid-19

Yıl 2022, Cilt: 52 Sayı: 3, 357 - 361, 30.12.2022

Gamze Çamlık Yıldız Özsoy , İsmail Tuncer Değim

https://doi.org/10.26650/IstanbulJPharm.2022.890376

Öz

As human beings, we communicate with each other just like other creatures. In the same way we need to communicate, COV- ID-19 has to communicate with other viruses. Following the latest Pandemic, combating COVID-19 has become a major need today. Several theories are being formulated and tested for the efficient prevention and treatment of the virus. Vaccination is the ultimate solution but access to the vaccine and getting vaccinated is limited. The purpose of this review paper is to present a new approach. This approach is based on the Quorum sensing of viruses like bacteria. Bacteria use this for communication and it has recently been proven for viruses too. It can be used as a new way or strategy to stop viral communication, therefore restricting the viral spread will possibly help people around the world or reduce the disease’s side effects. This new tactic in- volves the use of functionalized Quantum dots nanoparticles, and when they are coupled with carbon atoms and put to use in different delivery forms, these will be useful for maximum efficacy. The use of carbon quantum dots can be useful to minimize certain possible toxic effects. This may be greatly enhanced by doping boron atoms to the structure to trigger their synergistic effects. We suggest here that the inhaler form of this proposed drug delivery system should simultaneously provide a fairly high efficiency and a less toxic solution.

Anahtar Kelimeler

Quorum sensing, viral communication, quantum dots, carbon quantum dots, pulmonar drug delivery

Kaynakça

• Arumugam, S. S., & Malaichamy, I. (2015). Comprehensive mul- tispectroscopic analysis on the interaction and corona forma- tion of human serum albumin with gold/silver alloy nanopar- ticles. Journal of Physical Chemistry B, 119, 9461-9476. https://doi. org/10.1021/acs.jpcb.5b00436
• Arumugam, S. S., & Malaichamy, I. (2015). Comprehensive mul- tispectroscopic analysis on the interaction and corona forma- tion of human serum albumin with gold/silver alloy nanopar- ticles. Journal of Physical Chemistry B, 119, 9461-9476. https://doi. org/10.1021/acs.jpcb.5b00436
• Bi, J., Li, Y., Wang, H., Song, Y., Cong, S., Yu, C., Zhu, B. W., & Tan, M. (2017). Presence and formation mechanism of foodborne carbo- naceous nanostructures from roasted pike eel (Muraenesox ci- nereus). Journal of Agricultural and Food Chemistry, 66, 2862-2869. https://doi.org/10.1021/acs.jafc.7b02303
• Bi, J., Li, Y., Wang, H., Song, Y., Cong, S., Yu, C., Zhu, B. W., & Tan, M. (2017). Presence and formation mechanism of foodborne carbo- naceous nanostructures from roasted pike eel (Muraenesox ci- nereus). Journal of Agricultural and Food Chemistry, 66, 2862-2869. https://doi.org/10.1021/acs.jafc.7b02303
• Bourlinos, A. B., Trivizas, G., Karakassides, M. A., Baikousi, M., Kou- loumpis, A., Gournis, D., Bakandritsos, A., Hola, K., Kozak, O., Zbo- ril, R., Papagiannouli, I., Aloukos, P., & Couris, S. (2015). Green and simple route toward boron doped carbon dots with significantly enhanced non-linear optical properties. Carbon, 83, 173-179. https://doi.org/10.1016/j.carbon.2014.11.032
• Bourlinos, A. B., Trivizas, G., Karakassides, M. A., Baikousi, M., Kou- loumpis, A., Gournis, D., Bakandritsos, A., Hola, K., Kozak, O., Zbo- ril, R., Papagiannouli, I., Aloukos, P., & Couris, S. (2015). Green and simple route toward boron doped carbon dots with significantly enhanced non-linear optical properties. Carbon, 83, 173-179. https://doi.org/10.1016/j.carbon.2014.11.032
• Carnes, E. C., Lopez, D. M., Donegan, N. P., Cheung, A., Gresham, H., & Timmins, G.S. (2010). Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria. Nature Chemical Biol- ogy, 6(1), 41–45. https://doi.org/10.1038/nCHeMBIO.264
• Carnes, E. C., Lopez, D. M., Donegan, N. P., Cheung, A., Gresham, H., & Timmins, G.S. (2010). Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria. Nature Chemical Biol- ogy, 6(1), 41–45. https://doi.org/10.1038/nCHeMBIO.264
• Chen, D., Ganesh, S., Wang, W., & Amiji, M. M. (2017). Plasma pro- tein adsorption and biological identity of systemically adminis- tered nanoparticles. Nanomedicine, 12, 2113-2135. https://doi. org/10.2217/nnm-2017-0178
• Chen, D., Ganesh, S., Wang, W., & Amiji, M. M. (2017). Plasma pro- tein adsorption and biological identity of systemically adminis- tered nanoparticles. Nanomedicine, 12, 2113-2135. https://doi. org/10.2217/nnm-2017-0178
• Chen, D., Ganesh, S., Wang, W., & Amiji, M. M. (2019). Role of sur- face chemistry on serum protein corona-mediated cellular de- livery and gene silencing with lipid nanoparticles. Nanoscale, 11, 8760-8775. https://doi.org/10.1039/C8NR09855G
• Chen, D., Ganesh, S., Wang, W., & Amiji, M. M. (2019). Role of sur- face chemistry on serum protein corona-mediated cellular de- livery and gene silencing with lipid nanoparticles. Nanoscale, 11, 8760-8775. https://doi.org/10.1039/C8NR09855G
• Degim, I.T. & Kadioglu, D. (2013). Cheap, Suitable, Predictable and Manageable Nanoparticles for Drug Delivery: Quantum Dots, Current Drug Delivery, 10(1), 32-38.
• Degim, I.T. & Kadioglu, D. (2013). Cheap, Suitable, Predictable and Manageable Nanoparticles for Drug Delivery: Quantum Dots, Current Drug Delivery, 10(1), 32-38.
• Dietrich, L. E., Price-Whelan, A., Petersen, A., Whiteley, M., & New- man, D. K. (2006). The phenazine pyocyanin is a terminal signal- ing factor in the quorum sensing network of Pseudomonas ae- ruginosa. Molecular Microbiology, 61(5), 1308–1321. https://doi. org/10.1111/j.1365-2958.2006.05306.x
• Dietrich, L. E., Price-Whelan, A., Petersen, A., Whiteley, M., & New- man, D. K. (2006). The phenazine pyocyanin is a terminal signal- ing factor in the quorum sensing network of Pseudomonas ae- ruginosa. Molecular Microbiology, 61(5), 1308–1321. https://doi. org/10.1111/j.1365-2958.2006.05306.x
• Dolgin, E. (2019). The secret social lives of viruses. Na- ture, 570(7761), 290-292.
• Dolgin, E. (2019). The secret social lives of viruses. Na- ture, 570(7761), 290-292.
• Duncan, T. V. (2011). The communication challenges presented by nanofoods. Nature Nanotechnology, 6, 683-688.
• Duncan, T. V. (2011). The communication challenges presented by nanofoods. Nature Nanotechnology, 6, 683-688.
• Erez, Z., Steinberger-Levy, I., Shamir, M., Doron, S., Stokar-Avihail, A., Peleg, Y., Melamed, S., Leavitt, A., Savidor, A., Albeck, S., Amita, G. & Sorek, R. (2017). Nature, 541, 488–493. https://doi.org/10.1038/ nature21049
• Erez, Z., Steinberger-Levy, I., Shamir, M., Doron, S., Stokar-Avihail, A., Peleg, Y., Melamed, S., Leavitt, A., Savidor, A., Albeck, S., Amita, G. & Sorek, R. (2017). Nature, 541, 488–493. https://doi.org/10.1038/ nature21049
• Ghaderi, S., Ramesh, B. & Seifalian, A.M. (2011). Fluorescence nanoparticles “quantum dots” as drug delivery system and their toxicity: a review. Journal of Drug Targeting, 19(7), 475–486. https://doi.org/10.3109/1061186X.2010.526227
• Girma, W.M., Fahmi, M.Z., Permadi, A., Abate, M.A. & Chang, J.Y (2017). Synthetic strategies and biomedical applications of I-III-VI ternary quantum dots. Journal of Materials Chemistry, 5(31), 6193- 6216. https://doi.org/10.1039/C7TB01156C
• Girma, W.M., Fahmi, M.Z., Permadi, A., Abate, M.A. & Chang, J.Y (2017). Synthetic strategies and biomedical applications of I-III-VI ternary quantum dots. Journal of Materials Chemistry, 5(31), 6193- 6216. https://doi.org/10.1039/C7TB01156C
• Hu, W., Peng, C., Lv, M., Li, X., Zhang, Y., Chen, N., Fan, C. & Huang, Q. (2011). Protein corona-mediated mitigation of cytotoxicity of gra- phene oxide. ACS Nano, 5(5), 3693-3700. https://doi.org/10.1021/ nn200021j
• Hu, W., Peng, C., Lv, M., Li, X., Zhang, Y., Chen, N., Fan, C. & Huang, Q. (2011). Protein corona-mediated mitigation of cytotoxicity of gra- phene oxide. ACS Nano, 5(5), 3693-3700. https://doi.org/10.1021/ nn200021j
• Huang, R., Carney, R. P., Ikuma, K., Stellacci, F. & Lau, B. L. T. (2014). Effects of surface compositional and structural heterogeneity on nanoparticle protein interactions: Different protein configurations. ACS Nano, 8(6), 5402-5412. https://doi.org/10.1021/nn501203k
• Jiang, Q., Chen, J., Yang, C., Yin, Y. & Yao, K. (2019). Quo- rum Sensing: A Prospective Therapeutic Target for Bacterial Diseases. BioMed Research International, 7, 1-15. https://doi. org/10.1155/2019/2015978
• Jiang, Q., Chen, J., Yang, C., Yin, Y. & Yao, K. (2019). Quo- rum Sensing: A Prospective Therapeutic Target for Bacterial Diseases. BioMed Research International, 7, 1-15. https://doi. org/10.1155/2019/2015978
• Kandasamy, G. (2019). Recent Advancements in Doped/Co-Doped Carbon Quantum Dots for Multi-Potential Applications. Journal of Carbon Research, 5, 24-42. http://doi.org/10.3390/c5020024
• Kirtley, M. (2020, May). What is the size of the Covid-19 virus [Web log post]. Retrieved from https://www.quora.com/What-is-the- size-of-the-Covid-19-virus
• Kirtley, M. (2020, May). What is the size of the Covid-19 virus [Web log post]. Retrieved from https://www.quora.com/What-is-the- size-of-the-Covid-19-virus
• Li, Z. & Knetsch, M. (2018). Antibacterial strategies for wound dressing: preventing infection and stimulating healing. Current Pharmaceutical Design, 24(8), 936–951. https://doi.org/10.2174/1381612824666180213141109
• Lim, S.Y., Shen, W. & Gao, Z. (2014). Carbon quantum dots and their applications. The Royal Society of Chemistry, 44, 362-381. https://doi.org/10.1039/C4CS00269E
• Loczechin, A., Séron, K., Barras, A., Giovanelli, E., Belouzard, S., Chen, Y., Metzler-Nolte, N., Boukherroub, R. & Dubuisson, J. (2019). Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus. ACS Applied Materials & Interfaces, 11(46), 42964−42974. https://doi.org/10.1021/acsami.9b15032
• Martin,, L., Johannes, S., Tommy, C., Tord, B. R., Flanagan, M. B., Iseult,, L., Giuliano, E. & Kenneth, D. (2011). The evolution of the protein corona around nanoparticles: A test study. ACS Nano, 5(9), 7503-7509. https://doi.org/10.1021/nn202458g
• Nayak, P. S., Borah, S. M., Gogoi, H., Asthana, S., Bhatnagar, R., Jha A. N. & Jha, S. (2019). Lactoferrin adsorption onto silver nanoparticle interface: Implications of corona on protein con- formation, nanoparticle cytotoxicity and the formulation adju- vanticity. Chemical Engineering Journal, 361, 470-484. https://doi. org/10.1016/j.cej.2018.12.084
• Nayak, P. S., Borah, S. M., Gogoi, H., Asthana, S., Bhatnagar, R., Jha A. N. & Jha, S. (2019). Lactoferrin adsorption onto silver nanoparticle interface: Implications of corona on protein con- formation, nanoparticle cytotoxicity and the formulation adju- vanticity. Chemical Engineering Journal, 361, 470-484. https://doi. org/10.1016/j.cej.2018.12.084
• Pearson, J. P., Pesci, E. C. & Iglewski, B. H. (1997). Roles of Pseu- domonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes. Journal of Bacteriology, 179(18), 5756–5767. https://doi.org /10.1128/ jb.179.18.5756-5767.1997
• Pearson, J. P., Pesci, E. C. & Iglewski, B. H. (1997). Roles of Pseu- domonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes. Journal of Bacteriology, 179(18), 5756–5767. https://doi.org /10.1128/ jb.179.18.5756-5767.1997
• Shivaji, K., Mani, S., Ponmurugan, P., Castro, C.S., Davies, M.L., Bala- subramanian M.G. & Pitchaimuthu S. (2018). Green-Synthesis- Derived CdS Quantum Dots Using Tea Leaf Extract: Antimicro- bial, Bioimaging, and Therapeutic Application in Lung Cancer Cells. ACS Applied.Nano Materials, 1(4), 1683-1693. https://doi. org/10.1021/acsanm.8b00147
• Shivaji, K., Mani, S., Ponmurugan, P., Castro, C.S., Davies, M.L., Bala- subramanian M.G. & Pitchaimuthu S. (2018). Green-Synthesis- Derived CdS Quantum Dots Using Tea Leaf Extract: Antimicro- bial, Bioimaging, and Therapeutic Application in Lung Cancer Cells. ACS Applied.Nano Materials, 1(4), 1683-1693. https://doi. org/10.1021/acsanm.8b00147
• Song, Y., Wu,, Y., Wang, H., Liu, S., Song, L., Li, S. & Tan, M. (2019). Car- bon quantum dots from roasted Atlantic salmon (Salmo salar L.): Formation, biodistribution and cytotoxicity. Food Chemistry, 293, 387-395. https://doi.org/10.1016/j.foodchem.2019.05.017
• Song, Y., Wu,, Y., Wang, H., Liu, S., Song, L., Li, S. & Tan, M. (2019). Car- bon quantum dots from roasted Atlantic salmon (Salmo salar L.): Formation, biodistribution and cytotoxicity. Food Chemistry, 293, 387-395. https://doi.org/10.1016/j.foodchem.2019.05.017
• Song, Y., Wu, Y., Wang, H., Liu,, S., Song, L., Li, S. & Tan, M. (2020). Protein corona formation of human serum albumin with carbon quantum dots from roasted salmon. Food & Function, 11(3), 2358- 2367. http://doi.org/10.1039/C9FO02967B
• Song, Y., Wu, Y., Wang, H., Liu,, S., Song, L., Li, S. & Tan, M. (2020). Protein corona formation of human serum albumin with carbon quantum dots from roasted salmon. Food & Function, 11(3), 2358- 2367. http://doi.org/10.1039/C9FO02967B
• Turner, P. E. & Chao, L. (1999). Nature, 398, 441–443. Retrieved from https://www.nature.com/articles/18913
• Turner, P. E. & Chao, L. (1999). Nature, 398, 441–443. Retrieved from https://www.nature.com/articles/18913
• Van Delden, C., Pesci, E. C., Pearson, J. P., & Iglewski, B. H. (1998). Starvation selection restores elastase and rhamnolipid produc- tion in a Pseudomonas aeruginosa quorum-sensing mutant. In- fection and Immunity, 66(9), 4499–4502. http://doi.org/10.1128/ IAI.66.9.4499-4502.1998
• Van Delden, C., Pesci, E. C., Pearson, J. P., & Iglewski, B. H. (1998). Starvation selection restores elastase and rhamnolipid produc- tion in a Pseudomonas aeruginosa quorum-sensing mutant. In- fection and Immunity, 66(9), 4499–4502. http://doi.org/10.1128/ IAI.66.9.4499-4502.1998
• Xu, W., Dong, S., Han, Y., Li, S. & Liu, Y. (2018) Hydrogels as antibac- terial biomaterials. Current Pharmaceutical Design, 24(8), 843–854. https://doi.org/10.2174/1381612824666180213122953
• Xu, W., Dong, S., Han, Y., Li, S. & Liu, Y. (2018) Hydrogels as antibac- terial biomaterials. Current Pharmaceutical Design, 24(8), 843–854. https://doi.org/10.2174/1381612824666180213122953
• Yan, Y., Gause, K. T., Kamphuis, M. M. J., Ang, C., O’Brien-Simpson, N. M., Lenzo, J. C., Reynolds, E. C., Nice, E. C. & Frank, C. (2013). Differential roles of the protein corona in the cellular uptake of nanoporous polymer particles by monocyte and macrophage cell lines. ACS Nano, 7(12), 10960-10970. https://doi.org/10.1021/ nn404481f
• Yan, Y., Gause, K. T., Kamphuis, M. M. J., Ang, C., O’Brien-Simpson, N. M., Lenzo, J. C., Reynolds, E. C., Nice, E. C. & Frank, C. (2013). Differential roles of the protein corona in the cellular uptake of nanoporous polymer particles by monocyte and macrophage cell lines. ACS Nano, 7(12), 10960-10970. https://doi.org/10.1021/ nn404481f
• Yarwood, J. M., Bartels, D. J., Volper, E. M. & Greenberg, E. P. (2004). Quorum sensing in staphylococcus aureus biofilms. Journal of Bacteriology, 186(6), 1838–1850. http://doi.org/10.1128/ JB.186.6.1838-1850.2004
• Yarwood, J. M., Bartels, D. J., Volper, E. M. & Greenberg, E. P. (2004). Quorum sensing in staphylococcus aureus biofilms. Journal of Bacteriology, 186(6), 1838–1850. http://doi.org/10.1128/ JB.186.6.1838-1850.2004
• Yi, L., Li, Z., Yuan, K., Qu, X., Chen, J., Wang, G., Zhang, H., Luo, H., Zhu, L., Jiang, P., Chen, L., Shen, Y., Luo, M., Zuo, G., Hu, J., Duan, D., Nie, Y., Shi, X., Wang, W., Han,, Y., Li, T., Liu, Y., Ding, M., Deng,
• Yi, L., Li, Z., Yuan, K., Qu, X., Chen, J., Wang, G., Zhang, H., Luo, H., Zhu, L., Jiang, P., Chen, L., Shen, Y., Luo, M., Zuo, G., Hu, J., Duan, D., Nie, Y., Shi, X., Wang, W., Han,, Y., Li, T., Liu, Y., Ding, M., Deng,
• H. & Xu, X. (2004). Small Molecules Blocking the Entry of Severe Acute Respiratory Syndrome Coronavirus into Host Cells. Jour- nal of Virology, 78(20), 11334–11339. https://doi.org/10.1128/ JVI.78.20.11334-11339.2004
• H. & Xu, X. (2004). Small Molecules Blocking the Entry of Severe Acute Respiratory Syndrome Coronavirus into Host Cells. Jour- nal of Virology, 78(20), 11334–11339. https://doi.org/10.1128/ JVI.78.20.11334-11339.2004
• Zhu, R. R., Wang, W. R., Sun, X. Y., Liu, H. & Wang, S. L. (2010). Enzyme activity inhibition and secondary structure disruption of nano-TiO2 on pepsin. Toxicology in vitro, 24(6), 1639-1647. https:// doi.org/10.1016/j.tiv.2010.06.002
• Zhu, R. R., Wang, W. R., Sun, X. Y., Liu, H. & Wang, S. L. (2010). Enzyme activity inhibition and secondary structure disruption of nano-TiO2 on pepsin. Toxicology in vitro, 24(6), 1639-1647. https:// doi.org/10.1016/j.tiv.2010.06.002