Yara Giysisi İçin Potansiyel Bir Bitki: Polygonum Cognatum Meissn.'in Farmakolojik Aktivitelerinin 3B Hücre Kültürü Perspektifiyle Değerlendirilmesi

Yıl 2022, Cilt: 1 Sayı: 2, 75 - 80, 30.06.2022

Ufkay Karabay , Sıla Aze Bakan , R. Bugra Husemoglu , Mehtap Yuksel Egrılmez

Öz

Fizyolojik yara iyileşmesi, hemostaz/iltihap fazı, proliferasyon fazı ve yeniden şekillenme fazı tarafından düzenlenen karmaşık, çok yönlü bir süreçtir. Yara iyileşme mekanizmasının daha iyi anlaşılabilmesi için literatürde in vitro ve in vivo yara modelleri ile ilgili yeni raporlar yayımlanmaktadır. Otoimmün, diyabetik, bası ve yanık yaralarında doku onarımı yetersiz ilerleyebilmektedir. Bu bakımdan bu tür yaraları olan hastaların hücresel terapi ile tedavi edilmesi gerekebilmektedir. Rejeneratif tıp, hastalıklı ve yaralı dokuları iyileştirmek ve onarmak, normal işlevi eski haline getirmek ve sürdürmek için yaşam bilimlerine mühendislik ilkelerinin uygulandığı disiplinler arası bir çalışma alanıdır. Polygonum cognatum Meissn. (P. cognatum), ham protein, vitamin C, E, karotenoidler, Zn, Fe ve Mn elementleri, folik asit düzeyleri açısından zengin, antioksidan, antimikrobiyal, idrar söktürücü, antidiyabetik, antelmintik ve antifungal özelliklere sahip Polygonaceae familyasına ait çok yıllık yabani yenilebilir bir bitki türüdür. Bu derlemede, P. cognatum'un farmakolojik özelliklerini ve 3 boyutlu yapı iskelelerine aday olarak kullanımını incelemeyi amaçladık. “Polygonum Cognatum” anahtar kelimesi için PubMed ve Google Scholar veri tabanından literatür taraması yapılmış ve 15 makale tespit edilmiştir. Hücresizleştirme yoluyla bir 3D doku iskelesi olarak P. cognatum yaprakları, cilt yara örtüsü olarak özgün bir yaklaşım sunabilir.

Anahtar Kelimeler

Polygonum Cognatum Meissn., Yara İyileşmesi, İnflamasyon, 3B Doku İskelesi

A Potential Plant for Wound Dressing: Evaluation of the Pharmacological Activities of Polygonum Cognatum Meissn with a 3D Cell Culture Perspective

Öz

A physiologic wound healing is a complex multi-faceted process regulated by the hemostasis/inflammation, proliferation, and remodelling phases. In order to better understand the wound healing mechanism, novel reports are published in the literature with in vitro and in vivo wound models. Tissue repair may progress insufficiently in autoimmune, diabetic, pressure and burn wounds. In this regard, patients with like these wounds may need to be treated with cellular therapy. Regenerative medicine is an interdisciplinary field of study in which life sciences apply engineering principles to heal and repair diseased and injured tissues and restore and maintain normal function. Polygonum cognatum Meissn (P. cognatum) is an antioxidant and antimicrobial perennial wild edible plant belonging to the Polygonaceae family that is rich in crude protein, vitamin C and E, carotenoids, Zn, Fe and, Mn elements, folic acid. In this review, we aimed to summarize the pharmacological properties of P. cognatum and its potential use as a candidate for 3D scaffolds. The literature search from the database PubMed and Google Scholar was done for the keyword “Polygonum Cognatum” and 15 articles were identified. P. cognatum leaves as a 3D tissue scaffold by decellularization may present a unique approach as a skin wound dressing.

Anahtar Kelimeler

Polygonum Cognatum Meissn., Wound Healing, Inflammation, 3D Tissue Scaffold

Kaynakça

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