Nutrigenetics and Cancer

Yıl 2023, , 18 - 31, 26.12.2023

Zeynep Şilan Ceylan , Huriye Tümer

https://doi.org/10.47769/izufbed.1343199

Öz

A balanced and adequate diet is essential for a healthy life. Studies have shown a link between non-communicable diseases and nutrition. Cancer is a global health problem and is recognised as the second leading cause of death worldwide. Epidemiological studies have shown that a large proportion of cancers are related to lifestyle and diet. In order to prevent cancer and increase the success rate of treatment, it is important to investigate the relationship between cancer and diet. Nutrigenetics studies diet at the gene level and focuses on the interaction of nutrients with genes. The role of diet in cancer development and epigenetic changes in cancer make the relationship between nutrigenetics and cancer interesting. The protective and therapeutic effects of micronutrients and some bioactive food constituents on cancer have been demonstrated by in vivo and in vitro studies. Dietary effects on cancer can be observed through changes in DNA methylation, apoptosis, autophagy and gene expression. The aim of this review is to evaluate and present the mechanisms of action of some essential micronutrients (vitamin A, vitamin C, vitamin D), polyphenols (epigallocatechin-3-gallate, curcumin, resveratrol, genistein) and some macronutrients (polyunsaturated fatty acids) in the prevention and/or treatment of different types of cancer.

Anahtar Kelimeler

nutrition, nutrigetics, cancer and nutrition

Nütrigenetik ve Kanser

Öz

Sağlıklı bir yaşamın sürdürülebilmesi için dengeli ve yeterli beslenmek elzemdir. Yapılan çalışmalar neticesinde, bulaşıcı olmayan hastalıklar ve beslenme arasındaki ilişki ortaya konulmuştur. Kanser, küresel sağlık sorunlarından biridir ve dünya çapında ikinci önde gelen ölüm nedeni olarak kabul edilir. Epidemiyolojik çalışmalarda, kanserin büyük bir kısmının yaşam tarzı ve diyet ile ilişkili olduğu saptanmıştır. Kanserin önlenmesi ve tedavi sürecindeki başarı oranının arttırılması açısından, kanser ve beslenme ilişkisinin incelenmesi önem arz etmektedir. Nütrigenetik, beslenmeyi gen düzeyinde inceler ve besinlerin genler üzerindeki etkileşimine odaklanır. Beslenmenin kanser gelişimindeki rolü ve kanserde gerçekleşen epigenetik değişiklikler, nütrigenetik ve kanser arasındaki ilişkiyi ilgi çekici kılmaktadır. Mikro besin öğeleri ve bazı biyoaktif gıda bileşenlerinin kanser üzerindeki koruyucu ve terapotik etkileri, yapılan in vivo ve in vitro çalışmalarla ortaya konulmuştur. Beslenmenin, kanser üzerindeki etkileri DNA metilasyonu, apoptoz, otofaji, gen ekspresyonundaki değişiklikler ile gözlemlenebilmektedir. Bu derlemenin amacı, nütrigenetik açıdan bazı temel mikro besin ögelerinin (A vitamini, C vitamini, D vitamini), polifenollerin (epigallokateşin-3-gallat, kurkumin, resveratrol, genistein) ve bazı makro besin ögelerinin (çoklu doymamış yağ asitleri) farklı kanser türlerinin önlemesinde ve/veya tedavisinde sahip olabileceği etki mekanizmalarını değerlendirmek ve sunmaktır.

Anahtar Kelimeler

beslenme, nütrigenetik, kanser ve beslenme

Kaynakça

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• Verrax, J., & Calderon, P. B. (2008). The controversial place of vitamin C in cancer treatment. biochemical pharmacology, 76(12), 1644-1652.
• Virtamo, J., Pietinen, P., Huttunen, J. K., Korhonen, P., Malila, N., Virtanen, M. J., ... & Albert, P. (2003). Incidence of Cancer and Mortality Following α-Tocopherol and β-Carotene Supplementation: A Postintervention Follow-up. JAMA: Journal of the American Medical Association, 290(4).
• Wajed, S. A., Laird, P. W., & DeMeester, T. R. (2001). DNA methylation: an alternative pathway to cancer. Annals of surgery, 234(1), 10.
• Wang, J., Dai, Y., Huang, Y., Chen, X., Wang, H., Hong, Y., ... & Cheng, B. (2013). All-trans retinoic acid restores gap junctional intercellular communication between oral cancer cells with upregulation of Cx32 and Cx43 expressions in vitro. Medicina oral, patologia oral y cirugia bucal, 18(4), e569.
• Weng, Y. L., Liao, H. F., Li, A. F. Y., Chang, J. C., & Chiou, R. Y. Y. (2010). Oral administration of resveratrol in suppression of pulmonary metastasis of BALB/c mice challenged with CT26 colorectal adenocarcinoma cells. Molecular nutrition & food research, 54(2), 259-267.
• Yamaji, T., Inoue, M., Sasazuki, S., Iwasaki, M., Kurahashi, N., Shimazu, T., ... & Japan Public Health Center‐based Prospective Study Group. (2008). Fruit and vegetable consumption and squamous cell carcinoma of the esophagus in Japan: the JPHC study. International journal of cancer, 123(8), 1935-1940.
• YILMAZ, A. D. (2019). Vitamin D reseptör geni fokI polimorfizminin temporomandibular eklem dejenerasyonu ile ilişkisi. Mersin Üniversitesi Sağlık Bilimleri Dergisi, 12(1), 72-79.
• Zeisel, S. H. (2009). Epigenetic mechanisms for nutrition determinants of later health outcomes. The American journal of clinical nutrition, 89(5), 1488S-1493S.
• Zeljic, K., Supic, G., Stamenkovic Radak, M., Jovic, N., Kozomara, R., & Magic, Z. (2012). Vitamin D receptor, CYP27B1 and CYP24A1 genes polymorphisms association with oral cancer risk and survival. Journal of oral pathology & medicine, 41(10), 779-787.
• Zhang, N. (2015). Epigenetic modulation of DNA methylation by nutrition and its mechanisms in animals. Animal nutrition, 1(3), 144-151.
• Zhang, Z., Tang, H., Wang, Z., Zhang, B., Liu, W., Lu, H., ... & Li, G. (2011). MiR-185 targets the DNA methyltransferases 1 and regulates global DNA methylation in human glioma. Molecular cancer, 10(1), 1-16.
• Zhou, H., Chen, J. X., Yang, C. S., Yang, M. Q., Deng, Y., & Wang, H. (2014). Gene regulation mediated by microRNAs in response to green tea polyphenol EGCG in mouse lung cancer. BMC genomics, 15, 1-10.
• Zupančič, D., Korać-Prlić, J., Kreft, M. E., Franković, L., Vilović, K., Jeruc, J., ... & Terzić, J. (2020). Vitamin A rich diet diminishes early urothelial carcinogenesis by altering retinoic acid signaling. Cancers, 12(7), 1712.