Effect of Venlafaxine on The Vitamins Contents of Saccharomyces Cerevisiae (NRRLY-12632)

Yıl 2024, Cilt: 10 Sayı: 1, 218 - 227, 15.03.2024

Meltem Çakmak , Dursun Özer , Fikret Karataş , Sinan Saydam

https://doi.org/10.28979/jarnas.1397331

Öz

In this study, Saccharomyces cerevisiae (NRLLY-12632) was grown in YPD medium containing different concentrations of Venlafaxine ((RS)-1-[2-dimethylamino-1-(4-methoxyphenyl)-ethyl] cyclohexanol). To counteract the effect of venlafaxine, vitamin C was added to the growth medium, and vitamins content of S. cerevisiae were investigated by HPLC. It was found that the amounts of water-soluble vitamins and lycopene concentration in S. cerevisiae, decreased with increased venlafaxine concentration compared to the control (p<0.05). On the other hand, the amounts of fat-soluble vitamins A, E, and β-carotene concentration were found to be increased (p<0.05). The addition of vitamin C to the growth medium containing venlafaxine at different concentrations increased the number of water-soluble vitamins and lycopene content of S. cerevisiae, while decreasing the amount of fat-soluble vitamins A, E, and β-carotene, depending on vitamin C concentration. With the addition of vitamin C to the growth medium containing venlafaxine, all the vitamin concentrations get close to the control group. From these findings, it can be said that the negative effect of venlafaxine on S. cerevisiae is reduced by adding vitamin C to the growth medium of S. cerevisiae.

Anahtar Kelimeler

S. cerevisiae, venlafaxine, vitamins, HPLC

Kaynakça

• A. M. Gil-Rodriguez, A. V. Carrascosa, T. Requena, Yeasts in foods and beverages: In vitro characterisation of probiotic traits LWT, Food Science and Technology 64 (2) (2015) 1156–1162.
• H. Albergaria, N. Arneborg. Dominance of Saccharomyces cerevisiae in alcoholic fermentation processes: Role of physiological fitness and microbial interactions, Applied Microbiology and Biotechnology 100 (2016) 2035–2046.
• R. Gadassi, N. Mor. Confusing acceptance and mere politeness: Depression and sensitivity to Duchenne smiles, Journal of Behavior Therapy and Experimental Psychiatry 50 (2016) 8–14.
• H. J. Möller, I. Bitter, J. Bobes, K. Fountoulakis, C. Höschl, S. Kasper, Position statement of the European Psychiatric Association (EPA) on the value of antidepressants in the treatment of unipolar depression, European Psychiatry 27 (2012) 114–128.
• D. O. Kennedy, B vitamins and the brain: Mechanisms, dose and efficacy-A review, Nutrients 8 (68) (2016) 1–29.
• S. J. Devaki, R. L. Raveendran, Vitamin C: Sources, functions, sensing and analysis, in: A. H. Hamza (Ed.), Vitamin C, IntechOpen, 2017, Ch. 1, pp. 3–20.
• G. Cazzanelli, F. Pereira, S. Alves, R. Francisco, L. Azevedo, P. Dias Carvalho, A. Almeida, M. Côrte-Real, M. J. Oliveira, C. Lucas, M. J. Sousa, A. Preto, The yeast saccharomyces cerevisiae as a model for understanding RAS proteins and their role in human tumorigenesis, Cells 7 (2) (2018) E14 36 pages.
• R. Amidžić, J. Brborić, O. Čudina, S. Vladimirov, Rp-HPLC determination of vitamins, folic acid and B12 in multivitamin tablets, Journal of the Serbian Chemical Society C 70 (2005) 1229–1235.
• K. W. Miller, N. A. Lorr, C. S. Yang, Simultaneous determination of plasma retinol, α-tocopherol, lycopene, α-carotene, and β-carotene by high-performance liquid chromatography, Analytical Biochemistry 138 (2) (1984) 340–345.
• M. S. Ibrahim, Y. I. Ibrahim, Z. G. Mukhtar, F. Karatas, Amount of vitamin A, vitamin E, vitamin C, malondialdehyde, glutathione, ghrelin, beta-carotene, lycopene in fruits of Hawthorn, Midland (Crataegus laevigata), Journal of Human Nutrition and Food Science 5 (3) (2017) 1112–1117.
• K. S. El-Gendy, N. M. Aly, F. H. Mahmoud, A. Kenawy, A. K. H. El-Sebae. The role of vitamin C as antioxidant in protection of oxidative stress induced by imidacloprid, Food and Chemical Toxicology 48 (1) (2010) 215–221.
• E. Çöteli, F. Karataş, The research of the effects on antioxidant enzymes of yeasts exposed to chromium III chloride salt by adding vitamin C, Gümüşhane University Journal of Science and Technology 11 (4) (2021) 1071–1081.
• S. Acharya, U. R. Acharya, In vivo lipid peroxidation responses of tissues in lead-treated Swiss mice, Industrial Health 35 (1997) 542–544.
• F. Depeint, W. R. Bruce, N. Shangari, R. Mehta, P. J. O’Brien, Mitochondrial function and toxicity: Role of B vitamins on the one-carbon transfer pathways, Chemico-Biological Interactions 163 (2006) 113–132.
• F. Depeint, W. R. Bruce, N. Shangari, R. Mehta, P. J. O’Brien, Mitochondrial function and toxicity: Role of the B vitamin family on mitochondrial energy metabolism. Chemico-Biological Interactions 163 (2006) 94–112.
• L. M. Young, A. Pipingas, D. J. White, S. Gauci, A. Scholey, A systematic review and meta-analysis of B vitamin supplementation on depressive symptoms, anxiety, and stress: Effects on healthy and 'At-Risk' individuals, Nutrients 11 (9) (2019) 2232 19 pages.
• M. S. Ibrahim, M. Çakmak, D. Özer, F. Karataş, S. Saydam, Effect of vitamin C on cadmium depending growth and vitamin C contents of Citrobacter Freundii, Journal of Advanced Research in Natural and Applied Sciences 7 (3) (2021) 333–342.
• R. Medina-Silva, M. P. Barros, R. S. Galhardo, L. E. S. Netto, P. Colepicolo, C. F. M. Menck. Heat stress promotes mitochondrial instability and oxidative responses in yeast deficient in thiazole biosynthesis, Research in Microbiology 157 (3) (2006) 275–281.
• H. Liang, Q. Liu, J. Xu, The effect of riboflavin on lipid peroxidation in rats, Wei Sheng Yan Jiu 28 (1999) 370–371.
• R. S. Tupe, S. G. Tupe, V. V. Agte, Dietary nicotinic acid supplementation improves hepatic zinc uptake and offers hepatoprotection against oxidative damage, British Journal of Nutrition 105 (2011) 1741–1749.
• S. Zehra, M. A. Khan, Dietary pantothenic acid requirement of fingerling Channa punctatus (Bloch) based on growth, feed conversion, liver pantothenic acid concentration and carcass composition, Aquaculture Nutrition 24 (5) (2018) 1436–1443.
• M. Velásquez, D. Méndez, C. Moneriz, Pyridoxine decreases oxidative stress on human erythrocyte membrane protein, The Open Biochemistry Journal 13 (1) (2019) 37–44.
• H. Koyama, S. Ikeda, M. Sugimoto, S. Kume, Effects of folic acid on the development and oxidative stress of mouse embryos exposed to heat stress, Reproduction in Domestic Animals 47 (6) (2012) 921–927.
• E. A. Abdelfattah, Effect of different concentration and application time of vitamin B12 on antioxidant response of Physiophora alceae, African Journal of Biological Sciences 17 (1) (2021) 189–203.
• R. Roehrs, D. R. Freitas, A. Masuda, J. A. Henriques, T. N. Guecheva, A. L. L. Ramos, J. Saffi, Effect of vitamin A treatment on superoxide dismutase-deficient yeast strains, Archives of Microbiology 192 (3) (2010) 221–228.
• D. Satapathy, T. K. Dutta, A. Chatterjee, M. Karunakaran, M. K. Ghosh, A. Mohammad, Evaluation of ameliorative efficiency of vitamin E and Saccharomyces cerevisiae yeast on arsenic toxicity in Black Bengal kids, Small Ruminant Research 202 (2021) 106473 9 pages.
• J. Finaud, G. Lac, E. Filaire, Oxidative stress: Relationship with exercise and training, Sports Medicine 36 (2006) 327–358.
• S. Yu, I. Paetau-Robinson, Dietary supplements of vitamins E and C and β-carotene reduce oxidative stress in cats with renal insufficiency, Veterinary Research Communications 30 (2006) 403–413.
• P. D. Sarkar, T. Gupt, A. Sahu, Comparative analysis of lycopene in oxidative stress, The Journal of the Association of Physicians of India 60 (2012) 17–19.
• O. A., Kireçci, Effect of Heavy Metals (Manganese, Magnesium, Cadmium, and Iron) added Saccharomyces cerevisiae Culture Medium on Some Biochemical Parameters, Journal of Agriculture and Nature 20 (3) (2017) 175–184.