Comparison of Efficacy of Hyperthermic Intraperitoneal Chemotherapeutics Mitomycin C versus Oxaliplatin in Experimental Colorectal Peritoneal Metastasis Model

Yıl 2024, Cilt: 8 Sayı: 1, 181 - 191, 31.01.2024

Berke Manoğlu , Aras Emre Canda , Tugba Yavuzşen , Safiye Aktaş , Zekiye Altun , Osman Yılmaz , Tayfun Bişgin

https://doi.org/10.30621/jbachs.1339735

Öz

Aim: Our study aimed to establish a mouse model with colorectal cancer-induced peritoneal metastasis(PM) and to compare the efficacy of hyperthermic intraperitoneal chemotherapeutic agents, mitomycin C and oxaliplatin.
Materials and Methods: The peritoneal metastasis model was established in nude mice using the CC531 colon carcinoma cell line. Models with PM were randomized into four groups of seven animals each: Group-1, control group; Group-2, hyperthermic intraperitoneal chemotherapy(HIPEC) with mitomycin C(MMC), and Group-3, HIPEC with Oxaliplatin(OXA).
Results: Tumor development was achieved in all animals. While the tumor burden decreased significantly in the treatment Group-2(p=.013). In the PM mouse model, hyperthermic intraperitoneal administration of MMC had a higher tumoricidal effect than hyperthermic intraperitoneal administration of OXA.
Conclusions: Our PM model provided a good opportunity to examine the efficacy of HIPEC and IPIP. Hyperethermic intraperitoneal mitomycin applied in the colorectal PM animal model was found to have higher tumoricidal activity than oxaliplatin. In future studies, we plan to evaluate efficacies of different drugs in the PM models we have created.

Anahtar Kelimeler

peritoneal metastasis model, colorectal cancer, HIPEC

Destekleyen Kurum

Dokuz Eylül University Scientific Research Projects

Proje Numarası

2021.KB.SAG.063 and 2021.KB.SAG.003

Teşekkür

Dear Editor, We are submitting our manuscript entitled “Comparison of Efficacy of Hyperthermic Intraperitoneal Chemotherapeutics Mitomycin C versus Oxaliplatin In Experimental Colorectal Peritoneal Metastasis Model” We would greatly appreciate your consideration of our work for publication in the Journal of Basic and Clinical Health Sciences. Currently, studies in animal models of peritoneal metastasis have become very popular In our study, we compared the efficacy of two important chemotherapeutics, Mitomycin C and Oxaliplatin, in an animal model of colorectal peritoneal metastasis. We would like to share with you our results and the features and effectiveness of the intraperitoneal infusion pump we have developed. This manuscript has not been published before; that it is not under consideration for publication elsewhere; that its publication in the Journal of Basic and Clinical Health Sciences is approved by all co-authors. With best regards. Yours sincerely, Berke Manoglu, MD., PhD

Comparison of Efficacy of Hyperthermic Intraperitoneal Chemotherapeutics Mitomycin C versus Oxaliplatin in Experimental Colorectal Peritoneal Metastasis Model

Öz

Proje Numarası

2021.KB.SAG.063 and 2021.KB.SAG.003

Kaynakça

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