Relationship between myalgia and laboratory parameters in hospitalized patients with COVID-19

Yıl 2022, , 306 - 311, 15.03.2022

Dilek Yılmaz Okuyan , Meltem Karacan Gölen

https://doi.org/10.16899/jcm.1054978

Öz

Aim: Myalgia is among the first and most common symptoms in patients with COVID-19. A limited number of studies have been found evaluating the frequency of myalgia and the laboratory findings associated with this condition. In this study, we aimed to evaluate the prevalence of myalgia and the relationship between myalgia and laboratory parameters in patients who were hospitalized due to COVID-19.
Material and Methods: Three hundred fifty-eight patients with confirmed diagnoses of COVID-19 who were hospitalized between March 2020 and January 2021 were included in the study. The patients were divided into two groups according to the presence and absence of myalgia. Demographic characteristics, medical history, symptoms, clinical findings, and laboratory findings were evaluated retrospectively.
Results: A total of 358 patients, 192 (42.9%) females and 166 males, were included in the study. The mean age of the patients was 60.3 ± 15.2 years. When the laboratory findings of the 166 patients with myalgia and 192 patients with no myalgia were compared, no difference was found between the groups in terms of white blood cell, neutrophil, lymphocyte, monocyte, and platelet counts, C-reactive protein, ferritin D-dimer, and troponin levels. However, creatine kinase (CK) levels were found to be significantly higher in the group with myalgia compared with the group without myalgia (p<0.001). In 92 (25.6%) of 358 patients, the CK level was found to be higher than 200 U/L. The median value for CK was 55 U/L in the group without myalgia and 221 U/L in the group with myalgia.
Conclusion: Myalgia is one of the most common symptoms in COVID-19. In patients with myalgia, the CK level is higher than in patients without myalgia. These patients should be closely monitored in terms of the risk of rhabdomyolysis because high CK is an indicator of muscle damage.

Anahtar Kelimeler

COVID-19, creatine kinase, myalgia, rabdomiyoliz

Hospitalize Hastalarda Miyalji ve Laboratuar Parametreleri Arasındaki ilişki

Öz

Amaç: COVID-19 hastalarında miyalji ilk ve en yaygın semptomlar arasında yer almaktadır. Miyalji sıklığını ve bu durumla ilişkili laboratuar bulgularını değerlendiren sınırlı sayıda çalışmaya rastlanılmıştır. Bu çalışmada hastalığı daha şiddetli olması sebebiyle hospitalize takip edilen hastalarda miyalji sıklığını ve miyalji ile laboratuar parametreleri arasındaki ilişkiyi değerlendirmeyi amaçladık.
Yöntem: Bu çalışmaya Mart 2020- Ocak 2021 tarihleri arasında hastanede yatırılarak takip edilen COVID-19 tanısı doğrulanmış 358 hasta dahil edilmiştir. Miyalji varlığı ve yokluğuna göre hastalar 2 gruba ayrılmıştır. Demografik özellikler, tıbbi geçmiş, semptomlar, klinik bulgular ve laboratuvar bulguları retrospektif olarak değerlendirildi.
Bulgular: Bu çalışmaya 192'si (% 42,9) kadın, 166’sı erkek olmak üzere toplam 358 hasta dahil edildi. Hastaların yaş ortalaması 60,3 ± 15,2 idi. Miyalji tarifleyen 166 hasta ve tariflemeyen 192 hastanın laboratuar bulguları karşılaştırıldığında, white blood cell (WBC), neutrophil, lymphocyte, monocyte, platelet değerleri, C reactive protein (CRP), ferritin D-dimer, troponin düzeyleri arasında gruplar arası fark saptanmadı. Ancak miyalji olan grupta olmayan gruba göre creatine kinase (CK) düzeyleri anlamlı yüksek saptandı (p<0.001). 358 hastanın 92’sinde (%25,6) CK düzeyi 200 U/L 'den yüksek saptanmıştır. CK için ortanca değer miyaljisi olmayan grupta 55 U/L iken miyaljisi olan grupta 221 U/L olarak elde edilmiştir.
Sonuç: COVID-19'da miyalji en sık gözlenen bulgulardan biridir. Miyalji tarifleyen hastalarda CK düzeyi miyalji olmayan hastalara göre yüksektir. CK yüksekliği kas hasarı göstergesi olduğundan bu hastalar rabdomiyoliz riski açısından yakın izlenmelidir.

Anahtar Kelimeler

COVID-19, kreatin kinaz, miyalji, rabdomiyoliz

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