Outcomes of Low and Middle Income Children with Relapsed Acute Lymphoblastic Leukemia: Single-Center Experience

Yıl 2023, , 975 - 981, 30.09.2023

Zeliha Guzelkucuk , Özlem Arman Bilir , İkbal Ok Bozkaya , Dilek Kaçar , Melek Isik , Dilek Gürlek Gökçebay , Namık Yaşar Özbek , Hüsniye Neşe Yaralı

https://doi.org/10.16899/jcm.1345525

Öz

Abstract
Aim: Despite numerous advances in treating acute lymphoblastic leukemia (ALL) in children, relapse continues to be the leading cause of mortality. This study aimed to analyze the data of patient’s characteristics, and outcomes of children with relapsed ALL.
Material and Method: We retrospectively analyzed the records of patients aged 1–18 years diagnosed with relapsed ALL between January 2004 and December 2018.
Results: 452 ALL patients followed up in the study period and 55 patients relapsed. The relap-se rate was 12.1%. Thirty-four (61.8%) of the relapsed patients were male. The median age was seven years (1–17 years). Forty-six patients (83.6%) had precursor B-cell ALL and nine pati-ents (16.3%) had T-cell ALL. The site of relapse was bone marrow in 41 patients (74.5%), and extramedullary (central nervous system, testis, or soft tissue) in 11 patients (20%). The mean duration from the initial diagnosis to relapse was 32 months ( min-max: 4 -108 months, SD±21.2) and 20 months (min-max: 7-38 months, SD± 11.1) in patients with B- cell ALL and T- cell ALL respectively. The median follow-up time was 39.8 months (min-max: 3–198 months, SD±44.5) from the initial diagnosis. Thirty-seven patients (67.3%) died. The 5-year overall survival rate was 41.6%. Recurrent relapse and progressive disease were the most com-mon causes of death. The mortality rate was significantly associated with the immunophenotype, treatment response on days 8, 15, and 33 of initial diagnosis, the risk group at initial diagnosis, the site of relapse, and hematopoietic stem cell transplantation (p<0.05). Immunophenotype and the site of relapse were the independent variables associated with mortality.
Conclusion: Relapse affects a significant portion of patients with ALL. Survival rates are still poor in patients with relapsed ALL. Also, our findings that T-cell immunophenotype and the site of relapse (isolated bone marrow relapse) were independent risk factors for mortality sug-gest that more specialized treatment options are needed for patients with T-ALL and bone mar-row relapse.

Anahtar Kelimeler

Relapse, acute lymphoblastic leukemia, children

Destekleyen Kurum

No Funding

Nüks Eden Akut Lenfoblastik Lösemili Düşük ve Orta Gelirli Çocukların Sonuçları: Tek Merkez Deneyimi

Öz

Öz
Amaç: Çocuklarda akut lenfoblastik löseminin (ALL) tedavisindeki sayısız ilerlemeye rağmen, nüks mortalitenin önde gelen nedeni olmaya devam etmektedir. Bu çalışma ile, nüks eden ALL'li hasta özelliklerine ilişkin verileri ve çocukların sonuçlarını analiz etmeyi amaçlanmıştır.
Gereç ve Yöntem: Ocak 2004 ile Aralık 2018 tarihleri arasında nüks ALL tanısı alan 1-18 yaş arası hastaların kayıtlarını retrospektif olarak inceledik.
Bulgular: Çalışma döneminde 452 ALL hastası izlendi ve 55 hasta nüks ettiği görüldü. Nüks oranı %12.1 idi. Bu hastaların 34'ü (%61,8) erkekti. Medyan yaş 7 yıl (min-maks:1-17 yaş) idi. Kırk altı hastada (%83,6) öncül B-hücreli ALL ve dokuz hastada (%16,3) T-hücreli ALL vardı. Kırk bir hastada (%74,5) nüks yeri kemik iliği, 11 hastada (%20) ekstramedüller (merkezi sinir sistemi, testis veya yumuşak doku) idi. İlk tanıdan nükse kadar geçen ortalama süre B hücreli ALL'li hastalarda 32 ay (min-maks: 4 -108 ay, SD±21,2) ve T-hücre ALL’ de 20 ay (min-maks: 7-38 ay, SD± 11,1) idi. Tanıdan itibaren ortanca takip süresi 39,8 aydı (min-maks: 3–198 ay, SD±44,5). Otuz yedi hasta (%67,3) öldü. 5 yıllık genel sağkalım oranı %41.6 idi. Tekrarlayan nüks ve ilerleyici hastalık en yaygın ölüm nedenleriydi. Mortalite oranı, immünofenotip, ilk tanı-nın 8., 15. ve 33. günlerinde tedaviye yanıt, ilk tanı anındaki risk grubu, nüks bölgesi ve hematopoietik kök hücre nakli ile anlamlı şekilde ilişkiliydi (p<0.05). İmmünofenotip ve nüks bölge-si, mortalite ile ilişkili bağımsız değişkenlerdi.
Sonuç: Nüks, ALL hastalarının önemli bir bölümünü etkiler. Tekrarlayan ALL'li hastalarda hayatta kalma oranları hala düşüktür. Ayrıca, T-hücre immünofenotipi ve nüks bölgesi (izole kemik iliği nüksü) mortalite için bağımsız risk faktörleri olduğuna dair bulgularımız, T-ALL ve kemik iliği nüksü olan hastalar için daha özel tedavi seçeneklerine ihtiyaç olduğunu düşündürmektedir.

Anahtar Kelimeler

Nüks, akut lenfoblastik lösemi, çocuk

Kaynakça

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