Hiperamonyeminin Nadir Bir Nedeni: Valproik Asit Zehirlenmesi

Yıl 2015, Cilt: 6 Sayı: 3, 60 - 62, 01.07.2015

Duygu Selen Cengiz Muhammed Semih Gedik , Müge Gülen , Erdem Aksay Hayri Çınar Selen Acehan Akkan Avcı

Öz

Giriş: Valproik asit (VA) epilepsi ve bipolar duygu durum
bozukluğu tedavisinde ayrıca migren profilaksisinde yaygın olarak
kullanılan geniş spektrumlu bir antiepileptiktir. Yüksek doz alımlar,
letarjiden komaya kadar değişen merkezi sinir sistemi (MSS)
depresyonuna, solunum yetmezliğine, böbrek yetmezliğine,
akut pankreatite, hepatotoksisiteye ve kemik iliği depresyonuna
neden olabilmektedir.
Olgu Sunumu: Biz bu yazıda akut masif doz VA’ in neden olduğu
hiperamonyemik ensefalopatili olgunun L-karnitin ile tedavisini
son literatürler ışığında incelemeye çalıştık.
Sonuç: Acil servislerde (AS) nadir görülen bir zehirlenme olan
VA zehirlenmelerinde; ciddi zehirlenme bulguları ile beraber
hiperamonyemi varsa L-karnitin tedavisi akılda tutulması gereken
bir tedavi yaklaşımıdır.

Anahtar Kelimeler

Valproik asit, zehirlenme, hiperamonyemi, L-karnitin

A Rare Reason of Hyperammonemia: Valproic Acid Poisoning

Öz

Introduction: Valproic acid (VA) is a broad-spectrum antiepileptic drug that is widely used in the treatment of epilepsy and bipolar affective disorder and also in the prophylaxis of migraine. High doses can cause central nervous system depression ranging from lethargy to coma, respiratory failure, renal failure, acute pancreatitis, hepatotoxicity, and bone marrow depression.Case Report: In this paper, we attempted to examine a case of acute encephalopathy with hyperammonemia caused by high doses of VA and treated with L-carnitine based on the recent literature.Conclusion: In patients with hyperammonemia associated with the severe toxicity symptoms of poisoning, L-carnitine administration is a treatment approach to keep in mind based on the rare types of poisoning observed at emergency services

Anahtar Kelimeler

Valproic acid, poisoning, hyperammonemia, L-carnitine

Kaynakça

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