ALTIN NANOPARTİKÜLLER VE KANSERDE KULLANIMLARI

Yıl 2021, Cilt: 45 Sayı: 1, 70 - 95, 18.01.2021

Hatice Demirtaş Ceyda Şengel Türk

https://doi.org/10.33483/jfpau.773430

Cited By: 2

Öz

Amaç: Nanoteknolojnin hastalıkların teşhis ve tedavisinde kullanımı giderek artan bir şekilde ilgi görmektedir. Altın nanopartiküller (AuNP) sahip oldukları üstün özellikler sayesinde çeşitli kanser türlerinin teşhis ve tedavisinde kullanılmaktadırlar. Bu derleme kapsamında AuNP’ler hakkında genel bilgiler, kanserde kullanımlarına ilişkin olan bilimsel çalışmalar ve kaydedilen son gelişmeler akademik veri tabanları taranarak sunulmuştur.

Sonuç ve Tartışma: AuNP’lerin benzersiz optik, elektriksel ve fizikokimyasal özellikleri sayesinde bu sistemler kanser teşhis ve tedavisinde ilaç taşıyıcı sistem, görüntüleme ajanı, fototermal tedavi, fotodinamik tedavi ve biyosensör olarak kullanılmaktadır. AuNP sentezinin kolay olması ve pek çok ligand için yüzey modifikasyonuna elverişli olması bu kullanım alanları için büyük fayda sağlamaktadır. Bu özellikleri sayesinde AuNP’ler kanser tedavisinde umut verici sistemler olarak ön plana çıkmaktadır.

Anahtar Kelimeler

Altın nanopartiküller, ilaç taşıyıcı sistem, kanser

GOLD NANOPARTICULES AND USES IN CANCER

Öz

Objective: Nanotechnology has become more and more potentially used in diagnosis or treatment of diseases. Gold nanoparticles (AuNP) are used in the diagnosis and treatment of various cancer types thanks to their superior properties. Within the scope of this review, general information about AuNPs, scientific studies on their use in cancer and recent developments have been presented by scanning academic databases.

Result and Discussion: By means of the unique optical, electrical and physicochemical properties of AuNPs, it is used as a drug delivery system, imaging agent, photothermal therapy, photodynamic therapy and biosensor in cancer diagnosis and treatment. The fact that AuNP synthesis is easy and the nanoparticle surface is suitable for modification with many ligands provides great benefits for these applications. Thanks to these features, AuNPs come to the fore as promising systems in cancer treatment.

Anahtar Kelimeler

Cancer, drug delivery system, gold nanoparticles

Kaynakça

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