KENDİLİĞİNDEN EMÜLSİFİYE OLABİLEN İLAÇ TAŞIYICI SİSTEMLER

Yıl 2023, Cilt: 47 Sayı: 2, 705 - 718, 20.05.2023

Naz Baytok Ongun Mehmet Saka

https://doi.org/10.33483/jfpau.1244378

Cited By: 1

Öz

Amaç: Kendiliğinden emülsifiye olan ilaç taşıyıcı sistemler (SEDDS), henüz tamamen aydınlatılmamış olan muazzam bir potansiyele sahiptir. Oral lipid uygulamasında suda çözünürlüğü düşük olan ilaç bileşiklerinin formülasyonunda kullanılabilirler ve bu bileşiklerle ilişkilendirilen birçok problemin üstesinden gelebilirler. SEDDS, küçük parçacık boyutuna, geniş yüzey alanına, yüksek kapsülleme etkinliğine ve yüksek ilaç yüküne atfedilebilen bağırsak emilim bölgesindeki ilaç çözünürlüğünü optimize ederek oral emilim oranını ve derecesini artırabilir. Ayrıca, lipit bazlı formülasyonu nedeniyle SEDDS, hepatik ilk geçiş metabolizmasını atlayarak ve dolayısıyla biyoyararlanımı artırarak farmasötik lenfatik taşınmayı hızlandırabilir ve artırabilir.
Sonuç ve Tartışma: Terapötik açıdan etkili olan yeni lipofilik hidrofobik moleküllerin miktarı, yenilikçi ilaç geliştirme yaklaşımları sayesinde istikrarlı bir şekilde artmıştır. Farmasötik araştırmaların geleceği, yalnızca yeni moleküllerin keşfedilmesinden değil, aynı zamanda halihazırda bilinenlerin daha iyi kullanılmasından da geçebilir. Bu bileşiklerin oral biyoyararlanımını artırma stratejilerinden hidrofobik ve lipofilik ilaç moleküllerinin oral biyoyararlanımını artırmada SEDDS kullanımının oldukça başarılı olduğu kanıtlanmıştır.

Anahtar Kelimeler

Emülsifiye dozaj formları, ilaç çözünürlüğü, kendiliğinden emülsifikasyon, kendiliğinden emülsifiye olabilen ilaç taşıyıcı sistemler, lipofilik ilaçlar

SELF EMULSIFYING DRUG DELIVERY SYSTEMS - AN OVERVIEW

Öz

Objective: Self-Emulsifying Drug Delivery System (SEDDS) has tremendous potential that has yet to be completely realized. They can be used in the formulation of drug compounds that have low water solubility in oral lipid administration and overcome many problems associated with these compounds. The SEDDS can increase the rate and degree of oral absorption by optimizing drug solubility in the intestinal absorption site, attributable to its small particle size, large surface area, high encapsulation efficiency, and high drug load. Furthermore, due to its lipid-based formulation, SEDDS can accelerate and increase pharmaceutical lymphatic transport, bypassing hepatic first-pass metabolism and therefore enhancing bioavailability.
Result and Discussion: The quantity of novel therapeutically effective lipophilic molecules that are hydrophobic has steadily increased thanks to innovative drug development approaches. The future of pharmaceutical research may not only pass through the discovery of new molecules but also better exploitation of those already known. The use of SEDDS has been proven to be quite successful in enhancing the oral bioavailability of hydrophobic and lipophilic drug molecules among the strategies to increase the oral bioavailability of these compounds.

Anahtar Kelimeler

Drug solubility, emulsifying dosage forms, lipophilic drugs, self-emulsification, self-emulsifying delivery systems

Kaynakça

• 1. Tang, J., Sun, J., He, Z. (2007). Self-emulsifying drug delivery systems: Strategy for improving oral delivery of poorly soluble drugs. Current Drug Therapy, 2(1), 85-93. [CrossRef]
• 2. Baghel, P., Roy, A., Verma, S., Satapathy, T., Bahadur, S. (2020). Amelioration of lipophilic compounds in regards to bioavailability as self-emulsifying drug delivery system (SEDDS). Future Journal of Pharmaceutical Sciences, 6(1), 21. [CrossRef]
• 3. Shukla, R. (2018). Review on self emulsifying drug delivery system for delivery of drugs. Modern Applications in Pharmacy & Pharmacology, 1(5), 1-3. [CrossRef]
• 4. Nikolakakis, I., Partheniadis, I. (2017). Self-emulsifying granules and pellets: composition and formation mechanisms for instant or controlled release. Pharmaceutics, 9, 1-27. [CrossRef]
• 5. Sharma, D., Saxena, P., Singh, D.R.L., Singh, P. (2012). Self emulsifying drug delivery system: A novel approach. Journal of Pharmacy Research, 5(1), 500-504.
• 6. Sokkula, S.R., Gande, S. (2020). A comprehensive review on self-nano emulsifying drug delivery systems: Advancements and applications. International Journal of Pharmaceutical Sciences and Drug Research, 12(5), 576-583. [CrossRef]
• 7. Thapa, R.K., Choi, H., Kim, J.O., Yong, C.S. (2017). Analysis and optimization of drug solubility to improve pharmacokinetics. Journal of Pharmaceutical Investigation, 47(2), 95-110. [CrossRef]
• 8. Gursoy, N.R., Benita, S. (2004). Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomedicine and Pharmacotherapy, 58(3), 173-182. [CrossRef]
• 9. Sunitha, R., Sireesha, D.S., Aparna, M.V.L. (2011). Novel self-emulsifying drug delivery system-an approach to enhance bioavailability of poorly water soluble drugs. International Journal of Research in Pharmacy and Chemistry, 1(4), 828-838.
• 10. Tran, P., Park, J.S. (2021). Recent trends of self-emulsifying drug delivery system for enhancing the oral bioavailability of poorly water-soluble drugs. Journal of Pharmaceutical Investigation, 51, 439–463. [CrossRef]
• 11. Khedekar, K., Mittal, S. (2013). Self emulsifying drug delivery system: A review. International Journal of Pharmaceutical Sciences and Research, 4, 4494-4507.
• 12. Salawi, A. (2022). Self-emulsifying drug delivery systems: A novel approach to deliver drugs. Drug Delivery, 29(1), 1811-1823. [CrossRef]
• 13. Meirinho, S., Rodrigues, M.O., Santos, A., Falcao, A., Alves, G. (2022). Self-emulsifying drug delivery systems: An alternative approach to improve brain bioavailability of poorly water-soluble drugs through intranasal administration. Pharmaceutics, 14(7), 1487. [CrossRef]
• 14. Penchala, S., Pham, A.N., Huang, Y., Wang, J. (2011). Lipid‐Based and self‐emulsifying oral drug delivery systems. In: M. Hu and X. Li (Eds.), Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications, (pp. 343-354). Wiley Online Library, Chapter 21. [CrossRef]
• 15. Sapra, K., Sapra, A., Singh, S.K., Kakkar, S. (2012). Self emulsifying drug delivery system: A tool in solubility enhancement of poorly soluble drugs. Indo Global Journal of Pharmaceutical Sciences, 2(3), 313-332. [CrossRef]
• 16. Patil, P., Patil, V., Paradkar, A. (2007). Formulation of a self-emulsifying system for oral delivery of simvastatin: In vitro and in vivo evaluation. Acta Pharmaceutica, 57(1), 111-122. [CrossRef]
• 17. Karwal, R., Garg, T., Rath, G., Markandeywar, T.S. (2016). Current trends in self-emulsifying drug delivery systems (SEDDSs) to enhance the bioavailability of poorly water-soluble drugs. Critical Reviews in Therapeutic Drug Carrier Systems, 33(1), 1-39. [CrossRef]
• 18. Chatterjee, B., Almurisi, S.H., Dukhan, A.A.M., Mandal, U.K., Sengupta, P. (2016). Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view. Drug Delivery, 23(9), 3639-3652. [CrossRef]
• 19. Rani, S., Rana, R., Saraogi, G., Kumar, V., Gupta, U. (2019). Self-emulsifying oral lipid drug delivery systems: Advances and challenges. AAPS Pharmscitech, 20(3), 129. [CrossRef]
• 20. Pujara, N. (2012). Self emulsifying drug delivery system: A novel approach for enhancing solubility profile of poorly soluble drugs, (pp. 1-84). LAP LAMBERT Academic Publishing, ISSN: 9783659221798.
• 21. Mahapatra, A.K., Pn, M., Swadeep, B., Swain, R. (2014). Self-emulsifying drug delivery systems (SEDDS): An update from formulation development to therapeutic strategies. International Journal of PharmTech Research, 6, 546-568.
• 22. Bamba, J., Cave, G., Bensouda, Y., Tchoreloff, P., Pulsieux, F., Couarrraze, G. (1995). Cryoprotection of emulsions in freze-drying: Freezing process analysis. Drug Development and Industrial Pharmacy, 21, 1749-1760. [CrossRef]
• 23. Rahman, M.A., Harwansh, R., Mirza, M.A., Hussain, S., Hussain, A. (2011). Oral lipid based drug delivery system (LBDDS): Formulation, characterization and application: A review. Current Drug Delivery, 8(4), 330-345. [CrossRef]
• 24. Jessy, S., Digambar, J. (2010). Newer approches to self emulsifying drug delivery system. International Journal of Pharmacy and Pharmaceutical Sciences, 2(1), 37-42.
• 25. Singh, N., Rai, S., Bhattacharya, S. (2021). A conceptual analysis of solid self-emulsifying drug delivery system and its associate patents for the treatment of cancer. Recent Patents on Nanotechnology, 15(2), 92-104. [CrossRef]
• 26. Ibrahim, T., El-Megraba, N., Abdallaha, M. (2018). Self-emulsifying drug delivery formulations. Zagazig Journal of Pharmaceutical Sciences, 27(1), 1-21. [CrossRef]
• 27. Maji, I., Mahajan, S., Sriram, A., Medtiya, P., Vasave, R., Khatri, D. (2021). Solid self emulsifying drug delivery system: Superior mode for oral delivery of hydrophobic cargos. Journal of Controlled Release, 337, 646-660. [CrossRef]
• 28. Zhang, Y., Wang, R., Wu, J., Shen, Q. (2012). Characterization and evaluation of self-microemulsifying sustained-release pellet formulation of puerarin for oral delivery, International Journal of Pharmaceutics, 427(2), 337-344. [CrossRef]
• 29. Zanchetta, B., Chaud M.H., Santana, A.M.H. (2015). Self-Emulsifying Drug Delivery Systems (SEDDS) in Pharmaceutical Development. Journal of Advanced Chemical Engineering, 5(3), 427-521.
• 30. Singh, B., Bandopadheyay, S., Kapil, R., Singh, R., Katare, O. (2009). Self-emulsifying drug delivery systems (SEDDS): formulation development, characterization, and applications. Critical Reviews in Therapeutic Drug Carrier Systems, 26(5), 427-521. [CrossRef]