ÇOCUK HASTALIKLARINDA GELENEKSEL OLARAK KULLANILAN BAZI BİTKİLER

Yıl 2023, Cilt: 47 Sayı: 3, 1101 - 1118, 20.09.2023

Fatma Sarı , Şükran Kültür , Mine Koçyiğit

https://doi.org/10.33483/jfpau.1214245

Öz

Amaç: Çocuk hastalıklarının farklı türleri birçok insanın yaşamını fiziksel olarak olumsuz etkilemektedir. Burada geleneksel halk hekimliği olarak pediatri tedavisinde kullanılan bazı şifalı bitkileri belgelemeyi amaçladık.
Sonuç ve Tartışma: Tanımlanmış çocuk hastalıklarında kullanılan geleneksel bitkisel ilaçlar olarak 117 takson ve 53 familya tespit edilmiştir. Atıf sayılarına göre en sık kullanılan tıbbi bitki türleri Foeniculum vulgare Mill., Juglans regia L., Dryopteris filix-mas (L.) Schott, Rosa canina L., Mentha x piperita L., Matricaria chamomilla L. Tüm bulguların yeni farmasötik ürünler için temel oluşturması ve sağlık profesyonelleri için bir el kitabı olması bekleniyor.

Anahtar Kelimeler

Çocuk hastalıkları, etnobotanik, geleneksel tıp, tıbbi bitkiler, Türkiye

TRADITIONAL USAGES OF SOME MEDICINAL PLANTS FOR PEDIATRIC DISEASES

Öz

Objective: Different types of pediatric diseases negatively affect the lives of many people, physically. Here, we aimed to document some medicinal plants used as traditional folk medicine in pediatrics treatment.
Result and Discussion: 117 taxa and 53 families have been identified as traditional herbal medicines used in defined pediatric diseases. The most frequently used medicinal plant species according to the number of citations Foeniculum vulgare Mill., Juglans regia L., Dryopteris filix-mas (L.) Schott, Rosa canina L., Mentha x piperita L., Matricaria chamomilla L. All findings are expected to form the basis for new pharmaceutical products and become a handbook for healthcare professionals.

Anahtar Kelimeler

Ethnobotany, medicinal plants, pediatric diseases, traditional medicine, Turkey

Kaynakça

• 1. Kültür, Ş. (2015). Medicinal plant recipes from Kırklareli. Journal of Faculty of Pharmacy of Istanbul University, 44(1), 63-68.
• 2. Abbas, M.A., Jaffal, S.M., Al-Najjar, B.O. (2019). Analgesic and anxiolytic activities of Achillea biebersteinii: Evidence for the ınvolvement of GABAergic systems. Oriental Journal of Chemistry, 35(4), 1433-1442. [CrossRef]
• 3. Abubakar, U., Abdu Gawuna, T., Yusuf, K.M., Safiyanu, I., Saidu, S.R., (2017). Ethnopharmacological survey of medicinal plants used for the management of pediatric ailments in Kano State, Nigeria. Research Journal of Pharmacognosy, 4, 23-39.
• 4. Adeniyi, O.S., Omale, J., Omeje, S.C., Edino, V.O. (2017). Antidiarrheal activity of hexane extract of Citrus limon peel in an experimental animal model. Journal of Integrative Medicine, 15(2), 158-164. [CrossRef]
• 5. Akgul, A., Akgul, A., Senol, S.G., Yildirim, H., Secmen, O., Dogan, Y. (2018). An ethnobotanical study in Midyat (Turkey), a city on the silk road where cultures meet. Journal of Ethnobiology and Ethnomedicine, 14(1), 12. [CrossRef]
• 6. Akyol Y. (2013). Ethnobotanical studies in the Maldan Village (Province Manisa, Turkey). Marmara Pharmaceutical Journal, 1(17), 21-25. [CrossRef]
• 7. Al-Snafi, A.E. (2016). Medical importance of Cupressus sempervirens-A review. International Organization of Scientific Research Journal of Pharmacy, 6(6), 66-76.
• 8. Ali, Z. Nasir M.A., Khan Z. (2015). Evaluate the clinical efficacy of insty in the treatment of pyrexia, RADS Journal of Pharmacy and Pharmaceutical Sciences, 3(1), 72-75.
• 9. Alvisi, P., De Fazio, L., Valerii, M.C., Cavazza, E., Salerno, A., Lacorte, D., Spisni, E. (2017). Responses of blood mononucleated cells and clinical outcome of non-celiac gluten sensitive pediatric patients to various cereal sources: A pilot study. International Journal of Food Sciences and Nutrition, 68(8), 1005-1012. [CrossRef]
• 10. Asmare, T.W., Yilkal, B.A., Mekuannit, T.M., Yilbeltal, A.T. (2018). Traditional medicinal plants used to treat maternal and child health illnesses in ethiopia: An ethnobotanical approach. Journal of Traditional Medicine Clinical Naturopathy, 7(3), 1000277. [CrossRef]
• 11. Badgujar, S.B., Patel, V.V., Bandivdekar, A.H. (2014). Foeniculum vulgare Mill: A Review of its botany, phytochemistry, pharmacology, contemporary application, and toxicology. BioMed Research International, 2014, 842674. [CrossRef]
• 12. Omoruyi, O., Bafor, E.E., Omokaro, W.O., Edrada-Ebel, R., Uwumarongie, O.H., Elvis-Offiah, U.B., Viegelmann, C.V. (2017). Dryopteris filix-mas (Dryopteridaceae) leaves inhibit mouse uterine activity. Journal of Medicinal Plants for Economic Development, 1(1), 1-12.
• 13. Boadi, K.O., Kuitunen, M. (2005). Childhood diarrheal morbidity in the Accra Metropolitan Area, Ghana: Socio-economic, environmental and behavioral risk determinants. Journal of Health and Population in Developing Countries, 7(1), 15-22.
• 14. Bradley P. (1992). The British herbal compendium. In: Bradley P, editor. 1st ed. London: British Herbal Medicine Association; p. 257.
• 15. Bradley, F., 1992. Rodale’s All-New Encyclopedia of Organic Gardening. Rodale Press, Emmaus, Pennsylvania, USA, p. 39.
• 16. Briggs, C., 1993. Peppermint: Medicinal herb and flavouring agent. CPJ 126, 89-99.
• 17. Rather, M.A., Dar, B.A., Sofi, S.N., Bhat, B.A., Qurishi, M.A. (2016). Foeniculum vulgare: A comprehensive review of its traditional use, phytochemistry, pharmacology, and safety. Arabian Journal of Chemistry, 9, 1574-1583. [CrossRef]
• 18. Díaz-Maroto, M.C., Pérez-Coello, M.S., Esteban, J., Sanz, J. (2006). Comparison of the volatile composition of wild fennel samples (Foeniculum vulgare Mill.) from Central Spain. Journal of Agricultural and Food Chemistry, 54(18), 6814-6818. [CrossRef]
• 19. Díaz-Maroto, M.C., Díaz-Maroto Hidalgo, I.J., Sánchez-Palomo, E., Pérez-Coello, M.S. (2005). Volatile components and key odorants of Fennel (Foeniculum vulgare Mill.) and Thyme (Thymus vulgaris L.) oil extracts obtained by simultaneous distillation-extraction and supercritical fluid extraction. Journal of Agricultural and Food Chemistry, 53(13), 5385-5389. [CrossRef]
• 20. Choi, E. M., Hwang, J. K. (2004). Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare. Fitoterapia, 75(6), 557-565. [CrossRef]
• 21. Opinion of the Scientific Committee on Food on Estragole (1-Allyl-4-methoxybenzene) (2001), Scf/Cs/Flav/Flavour/6 Add2 Fınal, Brussels, Belgium.
• 22. Türkyılmaz, Z., Karabulut, R., Sönmez, K., Başaklar, A.C. (2008). A striking and frequent cause of premature thelarche in children: Foeniculum vulgare. Journal of Pediatric Surgery, 43(11), 2109-2111. [CrossRef]
• 23. Ghazanfarpour, M., Sadeghi, R., Kiani, M.A., Khorsand, I., Saeidi, M. (2014). Most common herbal medicines in the treatment of Iranian children: A systematic review. International Journal of Pediatrics, 2(4.3), 437-444. [CrossRef]
• 24. Stampar, F., Solar, A., Hudina, M., Veberic, R., Colaric, M. (2006). Traditional walnut liqueur-cocktail of phenolics. Food chemistry, 95(4), 627-631. [CrossRef]
• 25. Pereira, J. A., Oliveira, I., Sousa, A., Valentão, P., Andrade, P. B., Ferreira, I. C., Estevinho, L. (2007). Walnut (Juglans regia L.) leaves: Phenolic compounds, antibacterial activity and antioxidant potential of different cultivars. Food and Chemical Toxicology, 45(11), 2287-2295. [CrossRef]
• 26. Martínez, M.L., Labuckas, D.O., Lamarque, A.L., Maestri, D.M. (2010). Walnut (Juglans regia L.): Genetic resources, chemistry, by‐products. Journal of The Science of Food and Agriculture, 90(12), 1959-1967. [CrossRef]
• 27. Fukuda, T., Ito, H., Yoshida, T. (2003). Antioxidative polyphenols from walnuts (Juglans regia L.). Phytochemistry, 63(7), 795-801. [CrossRef]
• 28. Van Hellemont, J. (1986). Compendium de Phytotherapie, Association Pharmaceutique. Bruxelles, Belge, 371.
• 29. Bruneton, J. (1993). Pharmacognosie: Phytochimie plantes médicinales (No. 581.634 B7).
• 30. Wichtl, M., Anton, R. (1999). Plantes the ́rapeutiques. Tec. Doc., Paris, pp. 291-293.
• 31. Valnet, J., 1992. Phytothe ́rapie Traitement des maladies par les plantes. Maloine, Paris, pp. 476–478.
• 32. Girzu, M., Carnat, A., Privat, A.M., Fialip, J., Carnat, A.P., Lamaison, J.L. (1998). Sedative effect of walnut leaf extract and juglone, an isolated constituent. Pharmaceutical Biology, 36(4), 280-286. [CrossRef]
• 33. Khiljee, S., Ur Rehman, N., Khiljee, T., Loebenberg, R., Ahmad, R.S. (2015). Formulation and clinical evaluation of topical dosage forms of Indian Penny Wort, walnut and turmeric in eczema. Pakistan Journal of Pharmaceutical Sciences, 28(6), 2001-2007.
• 34. Petran, M., Dragos, D., Gilca, M. (2020). Historical ethnobotanical review of medicinal plants used to treat children diseases in Romania (1860s-1970s). Journal of Ethnobiology and Ethnomedicine, 16(1), 1-33. [CrossRef]
• 35. Kowalska M, Mendrycka M, Żbikowska A, Kowalska D. (2017). Assessment of astable cosmetic preparation based on enzymatic interesterified fat, proposed in the prevention of Atopic dermatitis. Acta Poloniae Pharmaceutica, 74(2), 465-476.
• 36. Streliaeva, A.V., Polzikov, V.V., Prokina, E.S., Kurilov, D.V., Chebyshev, N.V., Shcheglova, T.A., Sadykov, V.M. (2011). Development of a new hydrocarbon extract from the medicinal raw material of Circassian walnut (Juglans regia) and study of its antiparasitic activity. Meditsinskaia Parazitologiia i Parazitarnye Bolezni, Jul-Sep(3), 28-31.
• 37. Serakta, M., Djerrou, Z., Mansour-Djaalab, H., Kahlouche-Riachi, F., Hamimed, S., Trifa, W., Pacha, Y.H. (2013). Antileishmanial activity of some plants growing in Algeria: Juglans regia, Lawsonia inermis and Salvia officinalis. African Journal of Traditional, Complementary and Alternative Medicines, 10(3), 427-430. [CrossRef]
• 38. Güley, M., Söylemezoglu, T. (1976). Karadeniz bölgesinde yetişen erkek eğrelti otu, Dryopteris filix-mas, ekstresi üzerinde toksikolojik araştırma. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 6, 214-236.
• 39. Uwumarongie, H.O., Enike, M.A., Bafor, E.E. (2016). Pharmacognostic evaluation and gastrointestinal activity of Dryopteris filix-mas (L.) Schott (Dryopteridaceae). Ewemen Journal of Herbal Chemistry and Pharmacology Research, 2(1), 19-25.
• 40. Ali, M.S., Mostafa, K., Raihan, M.O., Rahman, M.K., Aslam, M. (2012). Antioxidant and cytotoxic activities of Methanolic extract of Dryopteris filix-mas (L.) Schott Leaves. International Journal of Drug Development and Research, 4, 223-229.
• 41. Soare, L.C., Ferdes, M., Stefanov, S., Denkova, Z., Nicolova, R., Denev, P., Paunescu, A. (2012). Antioxidant activity, polyphenols content and antimicrobial activity of several native pteridophytes of Romania. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 40(1), 53-57.
• 42. Urban, J., Tauchen, J., Langrova, I., Kokoska, L. (2014). In vitro motility inhibition effect of Czech medicinal plant extracts on Chabertia ovina adults. Journal of Animal Plant Sciences, 21(2), 3293-302.
• 43. Uwumarongie, H.O., Enike, M.A., Bafor, E.E. (2016). Pharmacognostic evaluation and gastrointestinal activity of Dryopteris filix-mas (L.) Schott (Dryopteridaceae). Ewemen Journal of Herbal Chemistry and Pharmacology Research, 2(1), 19-25.
• 44. Omoruyi, O., Bafor, E.E., Omokaro, W.O., Edrada-Ebel, R., Uwumarongie, O.H., Elvis-Offiah, U.B., Viegelmann, C.V. (2017). Dryopteris filix-mas (Dryopteridaceae) leaves inhibit mouse uterine activity. Journal of Medicinal Plants for Economic Development, 1(1), 1-12.
• 45. Erhirhie, E.O., Emeghebo, C.N., Ilodigwe, E.E., Ajaghaku, D.L., Umeokoli, B.O., Eze, P.M., Okoye, F.B.G.C. (2019). Dryopteris filix-mas (L.) Schott ethanolic leaf extract and fractions exhibited profound anti-inflammatory activity. Avicenna Journal of Phytomedicine, 9(4), 396.
• 46. Nilsson, O. (1997). Rosa. In: P.H. Davis (Ed.), Flora of Turkey and the East Aegean Islands, 4th edition, (pp. 106-128). Edinburgh: Edinburgh University Press.
• 47. Ercisli, S. (2005). Rose (Rosa spp.) germplasm resources of Turkey. Genetic Resources and Crop Evolution, 52, 787-795. [CrossRef]
• 48. Haas, L.F. (1995). Rosa canina (dog rose). Journal of Neurology, Neurosurgery, and Psychiatry, 59(5), 470. [CrossRef]
• 49. Chrubasik, C., Roufogalis, B.D., Müller‐Ladner, U., Chrubasik, S. (2008). A systematic review on the Rosa canina effect and efficacy profiles. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 22(6), 725-733. [CrossRef]
• 50. Lattanzio, F., Greco, E., Carretta, D., Cervellati, R., Govoni, P., Speroni, E. (2011). In vivo anti-inflammatory effect of Rosa canina L. extract. Journal of Ethnopharmacology, 137(1), 880-885. [CrossRef]
• 51. Ercisli, S., Güleryüz, M. (2005). Rose hip utilization in Turkey. Acta Horticulturae, (690), 77-82. [CrossRef]
• 52. Kurt, A., Yamankaradeniz, R. (1983). The composition of rose hip is grown naturally in Erzurum province and their processing possibilities to different products. Turkish Journal of Agriculture and Forestry, 7, 243-248.
• 53. Orhan, N., Aslan, M., Hoşbaş, S., Deliorman, O.D. (2009). Antidiabetic effect and antioxidant potential of Rosa canina fruits. Pharmacognosy Magazine, 5(20), 309-315. [CrossRef]
• 54. Butura, V. (1979). Enciclopedie de etnobotanica romaneasca. Bucuresti: Editura Stiintifica si Enciclopedica.
• 55. Marian, S.F. (2010). In: A. Brădăţan (Ed.), Botanica Poporana Romana, vol II-III. Bucuresti: Editura Academiei Române.
• 56. Bulut, G. (2011). Folk medicinal plants of Silivri (İstanbul, Turkey). Marmara Pharmaceutical Journal, 15(1), 25-29.
• 57. Leon, N. (1903). Istoria naturala medicala a poporului roman. In: Analele Acad Rom Ser II, Memoriile Sect Stiint. Bucuresti: Institutul de Arte Grafice Carol Gobl, 110. p. 163.
• 58. Bujorean, G. (1936). Boli, leacuri si plante de leac cunoscute de taranimea romana. The Association in Scotland to Research into Astronautics, 26, 1-398.
• 59. Herro, E., Jacob, S.E. (2010). Mentha piperita (peppermint). Dermatitis, 21(6), 327-329.
• 60. Briggs, C. (1993). Peppermint: Medicinal herb and flavouring agent. Canadian Pharmacists Journal, 126(2), 89-92.
• 61. Clark, R.K., Menory, R.C., (1980). Environmental effects or peppermint (Mentha piperita). Australian Journal of Plant Physiology. 7, 685-692.
• 62. Lis-Balchin, M., Deans, S.G., Hart, S. (1997). A study of the variability of commercial peppermint oils using antimicrobial and pharmacological parameters. Medical Science Research, 24, 309-311.
• 63. Chaumont, J.P., Senet, J.M. (1978). Antagonistic properties of higher plants against fungal parasites of man from food contaminants: Screening of 200 fungi. Plant Medicinal Phytotherapy, 12, 186-196.
• 64. Kline, R.M., Kline, J.J., Di Palma, J., Barbero, G.J. (2001). Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. The Journal of Pediatrics, 138(1), 125-128.
• 65. De Souza Silveira Valente, J., De Oliveira da Silva Fonseca, A., Denardi, L.B., Dal Ben, V.S., De Souza Maia Filho, F., Baptista, C.T., Pereira, D. I. B. (2016). In vitro susceptibility of Pythium insidiosum to Melaleuca alternifolia, Mentha piperita and Origanum vulgare essential oils combinations. Mycopathologia, 181, 617-622.
• 66. McKay, D.L., Blumberg, J.B. (2006). A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). Phytotherapy Research, 20(8), 619-633.
• 67. Laugier C. (1925). Contributiuni la etnografia medicala a Olteniei. Craiova: Editura Scrisul Romanesc, p.110.
• 68. Tetik, F., Civelek, S., Cakilcioglu, U. (2013). Traditional uses of some medicinal plants in Malatya (Turkey). Journal of Ethnopharmacology, 146(1), 331-346. [CrossRef]
• 69. Ulieru G. (1929). Florile bune de leac. Campulung-Muscel, Romania: Tipografia 113. Gheorghe N. Vladescu si Fiul.
• 70. Negru A. (2009). Cercetarea sociala institutionalizata in Transilvania si Banat. In: I. Bădescu, O. Cucu-Oancea, G. Şişeştean (Eds.), Tratat Sociol Rural. Bucuresti, Romania: Editura Mica Valahie;x p. 679-694.
• 71. Issac O. 1st ed. Czecho-Slovakia: Prague press; (1989). Recent progress in chamomile research-medicines of plant origin in modern therapy.
• 72. Pamukov D., Achtardziev C.H. 1st ed. Priroda: Bratislava; (1986.) Natural pharmacy (in Slova) p. 134.
• 73. Mann C, Staba E.J. (1986). The chemistry, pharmacology and commercial formulations of chamomile. In: L.E. Craker, J.E. Simon (Eds.). Herbs, Spices and Medicinal Plants-Recent Advances in Botany, Horticulture and Pharmacology, (pp. 235-280). Phoenix: Oryx Pres.
• 74. Tyihak, E., Sarkany-Kiss, J., Verzar-Petri, G. (1962). Phytochemical investigation of apigenin glycosides of Matricaria chamomilla. Pharmazie, 17, 301-304.
• 75. Subiza, J., Subiza, J.L., Marisa, A., Miguel, H., Rosario, G., Miguel, J. (1990). Allergic conjunctivitis to chamomile tea. Ann Allergy, 65, 127-132.
• 76. Fluck H. (1988). Medicinal plants and authentic guide to natural remedies, 1st ed. London: W. Foulsham and Co. Ltd.
• 77. Păcală, V. (1915). Monografia satului Răşinari. Sibiu, Romania: Tiparul Tipografiei Arhidiecezane. p.276.
• 78. Marian, S.F., Brădăţan, A. (2008). Botanica Poporana Romana, vol I. Suceava: Muşatinii. 111.
• 79. Henri, H., Nababan, V., Hakim, L. (2020). Ethnobotanical Study of Early Childhood Medicinal Plants Used by the Local People in South Bangka Regency, Indonesia. Biosaintifika: Journal of Biology Education, 12(3), 414-421.
• 80. Abbas, M.A., Jaffal, S.M., Al-Najjar, B.O. (2019). Analgesic and anxiolytic activities of Achillea biebersteinii: Evidence for the Involvement of GABAergic Systems. Oriental Journal of Chemistry, 35(4), 1433-1442. [CrossRef]
• 81. Shahraki M.R., Behmanesh B., Kosegharavi, Y. (2017). Indigenous knowledge of botanical herbs of medicinal herbs and ornamental plants among the villagers of thousand jerim of Mazandaran. The first national conference of herbs, aromatic and spices, Gonbad Kavoos, Golestan, Iran, pp. 17.
• 82. Metin, A. (2009). Mut ve çevresı̇nde yetı̇şen bı̇tkı̇lerı̇n (Mersı̇n) etnobotanı̇k özellı̇klerı̇, Selçuk Ünı̇versı̇tesı̇ Fen Bı̇lı̇mlerı̇ Enstı̇tüsü, Yüksek Lı̇sans Tezı̇. syf.40.
• 83. Iranmanesh, M., Najafi, S.H., Yosefi, M. (2010). Studies on ethnobotany of important medicinal plants in Sistan. Journal Herbal Drugs, vol. 1, no.2, pp. 58-65.
• 84. Genç G.E., Özhatay N. 2006. An ethnobotanıcal study in Çatalca (European Part Of Istanbul), Turkish Journal of Pharmacy Science. 3(2), 73-89.
• 85. Dolatkhahi, M., Nabipour, I. (2014). Ethnobotanical study of medicinal plants used in the Northeast Latrine zone of Persian Gulf. Journal of Medicinal Plants, 2, 129-143.
• 86. Safa, O., Soltanipoor, M. A., Rastegar, S., Kazemi, M., Nourbakhsh Dehkordi, K., Ghannadi, A. (2013). An ethnobotanical survey on hormozgan province, Iran. Avicenna Journal of Phytomedicine, 3(1), 64-81.
• 87. Ding J., Wang L., He J., Zhao J., Si L. Artemisia scoparia: Traditional uses, active constituents and pharmacological effects, Journal of Ethnopharmacology, 273, 113960. [CrossRef]
• 88. Razmjoue, D., Zarei, Z., Armand, R. (2017). Ethnobotanical Study (Identification, Medical Properties and How to use) of some Medicinal Plants of Behbahan city of Khuzestan Province, Iran Journal. Medicinal Plants, 16(4), 33-49.
• 89. Tuğba, A. ( 2011). Yenı̇şehı̇r (Bursa) Köylerı̇nı̇n Etnobotanı̇k Özellı̇klerı̇, Celal Bayar Ünı̇versı̇tesı̇ Fen Bı̇lı̇mlerı̇ Enstı̇tüsü, Yüksek Lisans Tezi, Syf 68.
• 90. Khodayari, H., Amani, S.H., Amiri, H. (2013). Ethnobotanical Study of North east of Khuzistan province. Medicinal Plants Ecophytochemistry, 2(4), 12-26.
• 91. Adeniyi, O.S., Omale, J., Omeje, S.C., Edino, V.O. (2017). Antidiarrheal activity of hexane extract of Citrus limon peel in an experimental animal model. Journal of Integrative Medicine, 15(2), 158-164. [CrossRef]
• 92. Ndhlovu, P.T., Omotayo, A.O., Otang-Mbeng, W., Aremu, A.O. (2021). Ethnobotanical review of plants used for the management and treatment of childhood diseases and well-being in South Africa. South African Journal of Botany, 137, 197-215. [CrossRef]
• 93. Türkyılmaz, Z., Karabulut, R., Sönmez, K., Can Başaklar, A. (2008). A striking and frequent cause of premature thelarche in children: Foeniculum vulgare. Journal of Pediatric Surgery, 43(11), 2109-2111. [CrossRef]
• 94. Iranmanesh, M., Najafi, S.H., Yosefi, M. (2010). Studies on ethnobotany of important medicinal plants in Sistan, Journal of Herbal Drugs, 1(2), 58-65.
• 95. Badgujar, S.B., Patel, V.V., Bandivdekar, A.H. (2014). Foeniculum vulgare Mill: A review of its botany, phytochemistry, pharmacology, contemporary application, and toxicology. BioMed Research International, 2014, 842674. [CrossRef]
• 96. Al-Snafi, A.E. (2016). Medical importance of Cupressus sempervirens-A review, IOSR Journal of Pharmacy, 6(6) 66-76. [CrossRef]
• 97. Dlisani, P.B., Bhat, R.B. (1999). Traditional health practices in transkei with special emphasis on maternal and child health. Pharmaceutical Biology, 37(1), 32-36. [CrossRef]
• 98. Condrea, A.(1991). Studii de etnobotanica in comuna Poiana Cristei, jud. Vrancea. 112. Muzeul Vranc Stud Şi Comun, 8(10), 281-286.
• 99. Rojni, H., Akbari, F. (2016). Indigenous knowledge of the use of native medicinal herbs in the village of Erim, a thousand acres of Neka. The first national conference of herbs medicinal and aromatic and spice, p.16.
• 100. Memariani, T., Hosseini, T., Kamali, H., Mohammadi, A., Ghorbani, M., Shakeri, A., Spandidos, D.A., Tsatsakis, A.M., Shahsavand, S. (2016). Evaluation of the cytotoxic effects of Cyperus longus extract, fractions and its essential oil on the PC3 and MCF7 cancer cell lines. Oncology Letters, 11(2), 1353-1360. [CrossRef]
• 101. Doost Azgomi, R.N., Akbarzadeh A., Ebrahimi F., Hoshbakht Z., Jazani A.M. (2016). Sanoon: A specialized dosage form for dental diseases in traditional Persian medicine. Biomedical Pharmacology Journal, 9(3), 1171-1182. [CrossRef]
• 102. Okere, O.S., Sangodele J.O., Tade O.G., Obafemi O.T., Falode J.A. (2015). Anti-diarrhea potential and acute toxicity studies of methanolic extract of Vernonia amygdalina and Cymbopogon citratus against castor oil induced diarrhea model in rats. International Journal of Biochemistry Research Review, 6(2), 46-52. [CrossRef]
• 103. Ulieru, G. (1929). Florile bune de leac. Campulung-Muscel, Romania: Tipografia 113. Gheorghe N. Vladescu si Fiul. p.310.
• 104. Negru, A. (2009). Cercetarea sociala institutionalizata in Transilvania si Banat. In: Bădescu I, Cucu-Oancea O, Şişeştean G, editors. Tratat Sociol Rural. Bucuresti, Romania: Editura Mica Valahie;x pp. 679–694.
• 105. Schloss, J., Ryan, K., Reid, R., Steel, A. (2019). A randomised, double-blind, placebo-controlled clinical trial assessing the efficacy of bedtime buddy® for the treatment of nocturnal enuresis in children. BMC Pediatrics, 19(1), 421.
• 106. Bulut, G. Tuzlacı, E. (2015). An ethnobotanical study of medicinal plants in Bayramiç. Marmara Pharmaceutical Journal, 19(3), 268-282. [CrossRef]
• 107. Mirdalimi, Z., Heshmati G.H.A., Barani H., (2014). Ethnobotanic and ethanological study of chicken medicinal species (Case study of kechik rangelands in northeast of golestan province). Journal Indigenous Knowledge Iran, 129-154. [CrossRef]
• 108. Koçyiğit, M., Ozhatay, N. (2006). Wıld plants used as medicinal purpose in Yalova (Northwest Turkey). Turkish Journal of Pharmacy Science, 3(2), 91-103.
• 109. Rahimi, R., Arkedani, M.R.S. (2013). Medicinal properties of Foeniculum vulgare Mill. in traditional Iranian medicine and modern phytotherapy, Chinese Journal of Integrative Medicine, 19(1), 73-79.
• 110. Khalaj, H, Labbafi, H.A, Hasan Abadi, T., Shaghaghi J., Hajiaghaee R.A. (2019). Review on the botanical, ecological, agronomical and pharmacological properties of the fennel (Foeniculum vulgare Mill.). Journal of Medicinal Plants, 18(69), 1-15.
• 111. Akyol, Y. (2013). Ethnobotanical studies in the Maldan Village (Province Manisa, Turkey). Marmara Pharmaceutical Journal 1(17), 21-25.
• 112. Kızılarslan, C., Ozhatay, N. (2012). Wild plants used as medicinal purpose in the south part of İzmı̇t (Northwest Turkey), Turkish Journal Pharmacia Sciences, 9(2), 199-218.
• 113. Ndhlovu, P.T., Omotayo, A.O., Otang-Mbeng, W., Aremu, A.O. (2021). Ethnobotanical review of plants used for the management and treatment of childhood diseases and well-being in South Africa. South African Journal of Botany, 137, 197-215. [CrossRef]
• 114. Asmare, T.W., Yilkal, B.A., Mekuannit, T.M., Yilbeltal, A.T. (2018). Traditional medicinal plants used to treat maternal and child health illnesses in Ethiopia: An ethno-botanical approach. Journal of Traditional Medicine Clinical Naturopathy, 7(3), 1000277. [CrossRef]
• 115. Hounsa, E., Agbodjento, E., Koudokpon, H., Legba, B., Fabiyi, K., Afaton, A., Sintondji, K., Akpode, B., Klotoé, J.R., Tchobo, F., Bankole, H. (2021). Toxicological characterization of ten medicinal plants of the beninese flora used in the traditional treatment of diarrheal diseases. Evidence-Based Complementary and Alternative Medicine, 2021, 6676904. [CrossRef]
• 116. Akgul, A., Akgul, A., Senol, S.G., Yildirim, H., Secmen, O., Dogan, Y. (2018). An ethnobotanical study in Midyat (Turkey), a city on the silk road where cultures meet. Journal of Ethnobiology and Ethnomedicine, 14(1), 12. [CrossRef]
• 117. Tetik, F., Civelek, S., Cakilcioglu, U. (2013). Traditional uses of some medicinal plants in Malatya (Turkey). Journal of Ethnopharmacology, 146(1), 331-346. [CrossRef]
• 118. Bulut, G., Haznedaroğlu, M.Z., Doğan, A., Koyu, H., Tuzlacı, E. (2017). An ethnobotanical study of medicinal plants in Acipayam (Denizli-Turkey). Journal of Herbal Medicine, 10, 64-81.
• 119. Alvisi, P., De Fazio, L., Valerii, M.C., Cavazza, E., Salerno, A., Lacorte, D., Spisni, E. (2017). Responses of blood mononucleated cells and clinical outcome of non-celiac gluten sensitive pediatric patients to various cereal sources: A pilot study. International Journal of Food Sciences and Nutrition, 68(8), 1005-1012. [CrossRef]
• 120. Ali, Z. Nasir M.A., Khan, Z. (2015). Evaluate the clinical efficacy of insty in the treatment of pyrexia, Journal of Pharmacy and Pharmaceutical Sciences, 3(1), 72-75.
• 121. Habibi, M., Solyman, S., Gholamali, P.E., Jorjani, E. (2013). Investigation of ethnobutane of highly used medicinal plants in shirvān. National Conference on Natural Resources Management. Gonbad Kavos, p. 13.
• 122. Pushpangadan, P., George, V., Ijinu, T.P., Chithra, M.A., Govindarajan, R. (2018). Resurgence of traditional medicine systems with special reference to ındian systems of medicine and modern scientific developments. Journal of Traditional Medicine Clinical Naturopathy, 7(3), 1000275. [CrossRef]
• 123. Emre, G. (2011). Folk medicinal plants of Silivri (İstanbul, Turkey). Marmara Pharmaceutical Journal, 15, 25-29.
• 124. Yeşil, Y., Çelik, M., Yılmaz, B. (2019). Wild edible plants in Yeşilli (Mardin-Turkey), a multicultural area. Journal of Ethnobiology and Ethnomedicine, 15, 52. [CrossRef]
• 125. Sarı, F., Koçyiğit, M. (2021). Ethnobotanical usages of the Turkish rumex taxa. Turkish Journal of Bioscience and Collections, 5(2), 123-140. [CrossRef]
• 126. Gradinaru, N. (2011). PhD Thesis. Medicina populară din Basarabia de la sfârșitul secolului al XIX-lea-începutul secolului al XX-lea. Aspecte istorico-etnografice [Internet]. Academia de Stiinţe a Moldovei, Chisinau.
• 127. Saric-Kundalic, B., Dobes, C., Klatte-Asselmeyer, V., Saukel, J. (2010). Ethnobotanical study on medicinal use of wild and cultivated plants in middle, south and west Bosnia and Herzegovina. Journal of Ethnopharmacology, 131(1), 33-55. [CrossRef]
• 128. Yılmaz, G., Şimşek, D., Altanlar, N., Çiçek, M. (2020). Comparison of the antimicrobial activity of some Scutellaria orientalis l. taxa growing in Turkey, International Journal of Secondary Metabolite, 7(3), 192-199. [CrossRef]
• 129. Khatun, A., Jannat, K., Jahan, R., Rahmatullah, M. (2018). Some plant-based home remedies used in Narayanganj district, Bangladesh. Journal of Medicinal Plants Studies, 6(4), 104-106.
• 130. Victorio Puche, L., Somoza, M.L., López-Sánchez, J.D., Garrido-Arandia, M., Díaz-Perales, A., Blanca, M. (2019). Peach tree pollen and prunus persica 9 sensitisation and allergy in children and adolescents. International Archives of Allergy and Immunology, 180(3), 212-220. [CrossRef]
• 131. Mokhtarifar, A., Zeydabadi, F.A., Asili, J., Kooshyar, M.M., Sahebkar, A. (2016). The effect of Portulaca oleracea (purslane) Ss on hemoglobin levels in adolescent girls with iron deficiency anemia: A randomized comparative trial. Comparative Clinical Pathology, 26(1), 11-16. [CrossRef]
• 132. Jabeen, N., Ajaib, M., Siddiqui, M.F., Khan, B. (2015). Survey of ethnobotanically important plants of district ghizer, Gilgit-Baltistan. Fuuast Journal of Biologie, 5(1), 153-160.
• 133. Pavelescu, G., Valea, S. (2004). Monografie etnofolclorică, vol.II. Folclor. Sibiu, Romania: Ed. Astra Museum.
• 134. Polat, R., Satıl, F. (2012). An ethnobotanical survey of medicinal plants in Edremit gölü (Balıkesir-Turkey). Journal of Ethnopharmacology, 139(2), 626-641. [CrossRef]
• 135. Hashmi, M.A., Khan, A., Hanif, M., Farooq, U., Perveen, S. (2015). Traditional uses, phytochemistry, and pharmacology of Olea europaea (Olive). Evidence-Based Complementary and Alternative Medicine, 2015, 1-29. [CrossRef]