Hücre Dışı Veziküller ve Eksozom

Yıl 2023, Cilt: 5 Sayı: 2, 245 - 257, 26.08.2023

Makbule Nihan Somuncu , Ayşe Gül Zamani , M. Selman Yıldırım

Öz

İnsan vücudundaki tüm hücreler hem normal hem de patolojik süreçlerde hücre dışı ortama küçük moleküller salgılamaktadırlar. Hücre dışı veziküller olarak tanımlanan bu nanomoleküller, son dönemlerde giderek daha da önem kazanan bireysel tanı, takip ve tedavi stratejilerine paralel olarak hastalık biyobelirteçi veya ilaç adayı olabilir mi, araştırmalarına öncülük etmektedir. Yapılan çalışmalar göstermektedir ki, vücutta yer alan tüm hücrelerden ekstraselüler ortama salgılanan bu moleküller, her hücrenin kendi biyolojik karakterizasyonu ile eşdeğer olduğundan salgılandığı hücrenin kimliğini de yansıtmaktadırlar. Dolayısıyla vücut sıvılarında yer alan bu veziküller tanı, tedavi ve takipte hücreye ulaşılamadığında veya hücre eldesinin zor olduğu durumlarda kullanılabilecek ve belki de girişimsel işlemlerin de yerine geçebilecek biyobelirteç özelliği gösterebileceklerdir. Eksozom, insan vücudunda yer alan tüm hücreler tarafından hücre dışı ortama salgılanan veziküllerin en küçüğüdür. Taşıdıkları hücreler arası ve hücre içi kargo muhteviyatları ile haberleşme ve sinyal yolaklarında görevli olabilmeleri, lipid kompozisyonları ile hücre içine kolaylıkla girebilme potansiyelleri ve son çalışmalarda bildirilen DNA, RNA, miRNA, lncRNA gibi nükleik asit sekanslarına sahip olabilmeleri, biyobelirteç adayı olarak atfedilmelerine yol açmıştır.

Anahtar Kelimeler

Eksozom, ultrasantrifüj, vezikül

Destekleyen Kurum

yok

Proje Numarası

bu bir derlemedir

Teşekkür

yok

Extracellular Vesicles and Exosomes

Öz

Proje Numarası

bu bir derlemedir

Kaynakça

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