Low Serum Vitamin D and Normal Serum 8-Hydroxy-2-Deoxyguanosine Levels in Endometrioma Patients: Is It a Dilemma?

Yıl 2019, Cilt: 16 Sayı: 4, 191 - 195, 31.12.2019

Neslihan Bayramoğlu Tepe , Özcan Balat , Tanyeli Güneyligil , Hüseyin Ozcan , Seyhun Sucu , Özge Kömürcü Karuserci , Mete Gürol Uğur , Hilmi Taşdemir

Öz

Amaç: Endometrioma hastalarında serum 25-OH vitamin D ve 8-Hidroksi 2-deoksigunazin (8-OH2dG) seviyelerini karşılaştırmak, kist boyutu ile ilişkisini saptamak.
Gereç ve Yöntemler: Çalışmaya endometrioma tanısı alan 54 hasta ile normal over dokusuna sahip 26 hasta kontrol grubu olarak dahil edildi. Serum örneklerinde 25-OH vitamin D ve 8-OH2dG seviyelerine bakıldı.
Bulgular: Hasta ve kontrol grubu arasında yaş, gebelik, doğum sayısı ve vücut kitle indexi (VKI) bakımından farklılık yoktu. Hasta grubunun D vitamini düzeyi, kontrol grubuna göre anlamlı derecede düşüktü (p=0.001). Kisti bilateral olan hastalar ile, kisti unilateral olan hastalar arasında D vitamini düzeyleri bakımından anlamlı farklılık yoktu (p=0.39). Hasta grubunda 48 (%88.8), kontrol grubunda 11 (%42.3) hastada D vitamini seviyesi <30-microgr/L idi. Hasta grubunda, D vitamini düzeyi hipovitaminoz seviyede olan hastalarda ortalama endometrioma çapı 58,4±25,14 mm iken, D vitamini düzeyi normal saptanan hastalarda endometrioma çapı ise 35,33±18,26 mm idi. Hipovitaminoz D saptanan hastalarda kist çapı ile D vitamini düzeyleri arasında ters bir ilişki saptandı. İki grup arasında 8-OH2dG düzeyleri bakımından anlamlı farklılık yoktu (p>0.05).
Sonuç: Endometrioma varlığı, kist çapı ve serum D vitamini düzeyleri arasında ters ilişki olmasına rağmen, serum 8-OH2dG düzeylerinde değişiklik yoktu. Bu durum, overyan endometriozisin patogenezinde hala belirsiz noktalar olduğunu göstermektedir.

Anahtar Kelimeler

Endometrioma, 25-OH vitamin D

Kaynakça

• Referans 1. Guidice LC, Tazuke SI, Swiersz L. Status of current research on endometriosis. J Reprod Med 1998; 43(3): 252-262.
• Referans 2 . Sourial S, Tempest N, Hapangama DK. Theroies on the pathogenesis of endometriosis. Int J Reprod Med 2014:179515.
• Referans 3. Missmer SA, Cramer DW. The epidemiology of endometriosis. Obstet Gynecol Clin N Am 2003; 30:1-19
• Referans 4. Buggio L, Roncella E, Somigliana E, Vercellini P. Vitamin D and benign gynaecological diseases: a critical analysis of the current evidence. Gynecol Endocrinol 2016; 32 (4): 259-263.
• Referans 5. Vigano P, Lattuada D, Mangioni S, et al. Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J. Mol. Endocrinol 2006; 36: 415-424.
• Referans 6. Christodoulakos G, Augoulea A, Lambrinoudaki I, Sioulas V, Creatsas G. Pathogenesis of endometriosis: the role of defective ‘immunosurveillance’. The European Journal of Contraception & Reproductive Health Care 2007; 12(3): 194–202.
• referans 7. Augoulea A, Mastorakos G, Lambrinoudaki I, Christodoulakos G, Creatsas G. The role of the oxidative stress in the endometriosis-related infertility. Gynecological Endocrinology 2009; 25(2): 75–81.
• Referans 8. Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reproductive Biology and Endocrinology 2005; 3: 28.
• Referans 9. Bellelis P, Dias JA, Podgaec S, Gonzales M, Baracat EC, Abrao MS. Epidemiological and clinical aspects of pelvic endometriosis-a case series. Revista da Associacao Medica Brasileira 2010; 56 (4): 467–471.
• Referans 10. Ciavattini A, Serri M, Delli Carpini G, Morini S, Clemente N. Ovarian endometriosis and Vitamin D serum levels. Gynecol Endocrinol 2017; 33 (2):164-167.
• Referans 11. Christodoulakos G, Augoulea A, Lambrinoudaki I, et al. Pathogenesis of endometriosis: the role of defective ’immunosurveillance’. Eur J Contracept Reprod Health Care 2007; 12:194–202.
• Referans 12. Anger DL, Foster WG. The link between environmental toxicant exposure and endometriosis. Front Biosci 2008; 13:1578–93.
• Referans 13. Akoum A, Kong J, Metz C, et al. Spontaneous and stimulated secretion of monocyte chemotactic protein-1 and macrophage migration inhibitory factor by peritoneal macrophages in women with and without endometriosis. Fertil Steril 2002; 77: 989–94.
• Referans 14. Lebovic DI, Mueller MD, Taylor RN. Immunobiology of endometriosis. Fertil Steril 2001; 75:1–10.
• Referans 15. Nothnick WB. Treating endometriosis as an autoimmune disease. Fertil Steril 2001; 76: 223–31.
• Referans 16. Grzechocinska B, Dabrowski FA, Cyganek A, et al. The role of vitamin D in impaired fertility treatment. Neuro Endocrinol Lett 2013; 34:756–62.
• Referans 17. Miyashita M, Koga K, Izumi G, et al. Effects of 1,25-Dihydroxy Vitamin D3 on Endometriosis. J Clin Endocrinol Metab 2016; 101: 2371–9.
• Referans 18. Somigliana E, Panina-Bordignon P, Murone S, et al. Vitamin D reserve is higher in women with endometriosis. Hum Reprod 2007; 22:2273–8.
• Referans 19. Buggio L, Somigliana E, Pizzi MN, Dridi D, Roncella E, Vercellini P. 25-Hydroxyvitamin D Serum Levels and Endometriosis: Results of a Case–Control Study. Reprod Sci 2018. https://doi.org/10.1177/1933719118766259
• Referans 20.Harris HR, Chavarro JE, Malspeis S, et al. Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: a prospective cohort study. Am J Epidemiol 2013; 177:420–30.
• Referans 21. Matyjaszek-Matuszek B, Lenart-Lipin´ska M, Woz´niakowska E. Clinical implications of vitamin D deficiency. Prz Menopauzalny 2015; 14:75–81.
• Referans 22. Didriksen A, Grimnes G, Hutchinson MS, et al. The serum 25- hydroxyvitamin D response to vitamin D supplementation is related to genetic factors, BMI, and baseline levels. Eur J Endocrinol 2013; 169:559–67.
• Referans 23. Abbas MA, Taha MO, Disi AM, et al. Regression of endometrial implants treated with vitamin D3 in a rat model of endometriosis. Eur J Pharmacol 2013; 715: 72–5.
• Referans 24. Parazzini F, Esposito G, Tozzi L, Noli S, Bianchi S. Epidemiology of endometriosis and its comorbidities. Eur J Obstet Gynecol Reprod Biol 2017; 209: 3–7.
• Referans 25. Vuolo L, Di Somma C, Faggiano A, Colao A. Vitamin D and cancer. Front Endocrinol 2012; 3:58.
• Referans 26. Bouillon R, Carmeliet G, Verlinden L, et al. Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice. Endocrine Reviews 2008; 29: 6 (1): 726-776.
• Referans 27. Grzegorz P, Iwona W, Bartłomiej B, Wojciech K, Wiesława B, Jan K. Increased levels of oxidative stress markers in the peritoneal fluid of women with endometriosis. Eur J Obstet Gynecol Reprod Biol 2013; 168 :187-190.
• Referans 28. Carvalho LF, Samadder AN, Agarwal A, Fernandes LF, Abrão MS. Oxidative stress biomarkers in patients with endometriosis: systematic review. Arch Gynecol Obstet 2012 Oct; 286(4): 1033-40.
• Referans 29. Matsuzaki S, Schubert B. Oxidative stress status in normal ovarian cortex surrounding ovarian endometriosis. Fertility and Sterility 2010; 93:2431–2.
• Referans 30. Kao SH, Huang HC, Hsieh RH, Chen SC, Tsai MC, Tzeng CR. Oxidative damage and mitochondrial DNA mutations with endometriosis. Annals of the New York Academy of Sciences 2005;1042: 186–94.
• Referans 31. Da Broi MG, de Albuquerque FO, de Andrade AZ, Cardoso RL, Jordão Junior AA, Navarro PA. Increased concentration of 8-hydroxy-2'-deoxyguanosine in follicular fluid of infertile women with endometriosis. Cell Tissue Res. 2016 Oct; 366(1): 231-42.
• Referans 32. Seino T, Saito H, Kaneko T, Takahashi T, Kawachiya S, Kurachi H. Eight-hydroxy-2′-deoxyguanosine in granulosa cells is correlated with the quality of oocytes and embryos in an in vitro fertilization-embryo transfer program. Fertil Steril 2002; 77:1184–1190.
• Referans 33. Tamura H, Takasaki A, Miwa I, et al. Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate. J Pineal Res 2008; 44:280–287.
• Referans 34. Benaglia L, Bermejo A, Somigliana E, et al. In vitro fertilization outcome in women with unoperated bilateral endometriomas. Fertil Steril 2013; 99:1714–19.