Comparison of Vimentin Levels Between Preeclamptic and Normotensive Pregnant Women

Yıl 2020, Cilt: 17 Sayı: 4, 610 - 614, 31.12.2020

Emsal Pınar Topdağı Yılmaz , Yunus Emre Topdağı , Seda Aşkın

https://doi.org/10.38136/jgon.710511

Cited By: 1

Öz

Background: To compare the serum vimentin levels between the pregnant women diagnosed with preeclampsia (PE) and the normal pregnant women.
Materials and Methods: This sectional study was conducted on 40 pregnant women diagnosed with preeclampsia and 21 healthy pregnant women. The maternal serum vimentin levels were evaluated via the sandwich enzyme immunoassay method.
Results: The mean vimentin levels were found significantly different between the groups. (47.25±29.74 vs.19.39±3.76 p=0.000) No significant difference was discovered between the two groups in respect of the gestational week, platelet level, parity and body mass index (BMI) during the diagnosis (p>0.05).
Conclusion: Findings demonstrate that vimentin plays a role in the pathogenesis of preeclampsia. However, further studies, in which the number of patients is high and subgroups are compared, are needed.

Anahtar Kelimeler

preeclampsia, vimentin, pregnancy, hypertension

Preeklamptik ve Normotansif Gebeler Arasındaki Vimentin Seviyelerinin Karşılaştırılması

Öz

Amaç: Preeklampsi (PE) tanısı alan gebeler ile normal gebeler arasındaki serum vimentin seviyelerini karşılaştırmaktır.
Materyal Method: Kesitsel tipteki bu çalışmada 40 preeklampsi tanısı alan gebe kadın ve 21 sağlıklı gebe üzerinde gerçekleştirilmiştir. Maternal serum vimentin seviyeleri sandwich enzim immunoassay yöntemi ile değerlendirilmiştir.
Sonuç: Ortalama vimentin düzeyleri gruplar arasında anlamlı olarak farklı saptandı. (47,25±29,74 vs.19,39±3,76 p=0,000) Tanı esnasındaki gebelik haftası, trombosit seviyesi, parite ve vücut kitle indeksi (VKİ) açısından iki grup arasında anlamlı farklılık saptanmadı (p>0.05).
Tartışma: Bulgular vimentinin preeklampsinin patogenezinde rol oynadığını göstermektedir. Ancak hasta sayısı yüksek ve subgrupların karşılaştırıldığı daha ileri çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

preeklampsi, vimentin, gebelik, hipertansiyon

Kaynakça

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