Evaluation of neutrophil lymphocyte and platelet lymphocyte ratios according to disease activity ındex in rheumatoid arthritis

Yıl 2020, Cilt: 3 Sayı: 3, 312 - 316, 18.06.2020

Ayşe Gülşen Doğan , Mehmet Boyacıoğlu Murat Doğan

https://doi.org/10.32322/jhsm.737131

Cited By: 1

Öz

Objective: Rheumatoid arthritis (RA) cause of unknown origin, joints and destruction; is an autoimmune, chronic, multisystemic disease. In this study, we aimed to investigate neutrophil/lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) rates and mean platelet volume (MPV) ratios in patients using methotrexate and Anti-TNF blockers in patients with rheumatoid arthritis.
Material and Method: Sixty patients with rheumatoid arthritis and a control group of 70 healthy individuals was included in this retrospective study. The patient group was divided into three groups according to DAS 28 score. ROC analysis was performed to analyze the diagnostic values of NLR and PLR parameters. All analyzes were done in 95% confidence interval and in SPSS 17.0 for Windows package program.
Resullts: Age, CRP, sedim, NLR and PLR values in the patient group; MPV levels were higher in the control group. MPV values in DAS28-I group; NLR and PLR levels were the highest in patients in the DAS28-III group.
Conclusion: NLR and PLR values have been shown as a useful marker to evaluate disease activity in RA patients. However, more comprehensive studies are needed to use MPV values as indicators of disease activity in RA patients. 

Anahtar Kelimeler

Neutrophil-lymphocyte ratio, NLR, platelet lymphocyte ratio, PLO, rheumatoid arthritis, RA

Romatoid artritte nötrofil lenfosit ve platelet lenfosit oranlarının hastalık aktivite indeksine göre değerlendirilmesi

Öz

Amaç: Bu çalışmanın amacı, romatoid artrit hastalarında nötrofil/lenfosit oranı (NLO),platelet lenfosit oranı (PLO) ve ortalama platelet volümü (MPV) değerlerinin hastalık aktivite skoruna (DAS 28) göre değişimini incelemektir.
Gereç ve Yöntem: Altmış romatoid artrit hastası ve 70 sağlıklı bireyden oluşmuş kontrol grubu bu retrospektif çalışmaya dâhil edildi. Hasta grubu DAS 28 skoruna göre üç gruba ayrıldı. NLO ve PLO parametrelerinin tanısal değerlerinin analizi için ROC analizi yapıldı. Tüm analizler %95 güven aralığında ve SPSS 17.0 for Windows paket programında yapıldı.
Bulgular: Yaş, CRP, sedim, NLO ve PLO değerleri hasta grubunda; MPV düzeyleri ise kontrol grubunda daha yüksekti. MPV değerleri DAS28-I grubunda; NLO ve PLO düzeyleri ise DAS28-III grubu hastalarda en yüksek düzeydeydi.
Sonuç: NLO ve PLO değerleri, RA hastalarında hastalık aktivitesini değerlendirmek için yararlı bir belirteç olarak gösterilmiştir. Bununla birlikte, RA hastalarında MPV değerlerini hastalık aktivitesinin göstergesi olarak kullanabilmek için daha kapsamlı çalışmalara ihtiyaç vardır. 

Anahtar Kelimeler

Nötrofil lenfosit oranı, NLO, platelet lenfosit oranı, PLO, romatoid artrit, RA

Kaynakça

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