Mini-review of the bi-component nanofibrous scaffolds and drug delivery applications

Yıl 2024, Cilt: 4 Sayı: 2, 391 - 413, 31.07.2024

Fatma Nur Parın

https://doi.org/10.61112/jiens.1417524

Öz

Drug delivery systems perform to improve the drug's efficacy and heal the affected region. Electrospun nanofibers are strong drug carriers as a scaffold due to their high specific surface area, easy processing, lightweight material. Fibrous scaffolds encapsulating functional bioactive agents are important for drug delivery applications, and they show higher encapsulation efficiency and higher drug loading capacity than various types of carrier materials such as hydrogels, micro/nanobeads, films, conventional fibers, and sponges. In comparison to conventional electrospinning, bi-component electrospinning where drug loading does not occur largely on the surface of the polymer matrix, core-shell nanofibers showed delayed release and a decrease in burst release because the drug was loaded into the core layer. The purpose of this mini-review is to investigate the production and applications of the drug-loaded bi-component nanofibers in structure core-shell, side-by-side, hollow nanofibers, and also emulsion nanofibers using co-axial nozzles. Further, the parameters which influence of these electrospinning process, such as working conditions and polymer properties, as well as drug delivery profile of the resulting nanofibers, have been outlined briefly. The limited clinical studies on the nanofibers have been discussed. Eventually, perspectives on the problems, possibilities, and new approaches for electrospinning advancements have been presented, as well.

Anahtar Kelimeler

Bi-component nanofiber, Co-axial electrospinning, Side-by-side electrospinning, Nanofibrous scaffold, Drug delivery applications

Bi-component nanofibröz iskelelerin ve ilaç salım uygulamalarının mini incelemesi

Öz

İlaç salım sistemleri, ilacın etkinliğini artırmak ve etkilenen bölgeyi iyileştirmek için gerçekleştirir. Elektroçekilmiş nanolifler, yüksek özgül yüzey alanı, kolay işleme, hafif malzeme nedeniyle iskele olarak güçlü ilaç taşıyıcılarıdır. Fonksiyonel biyoaktif maddeleri kapsülleyen lifli iskeleler, ilaç verme uygulamaları için önemlidir ve hidrojeller, mikro / nanobeadler, filmler, geleneksel lifler ve süngerler gibi çeşitli taşıyıcı malzemelere göre daha yüksek kapsülleme verimliliği ve daha yüksek ilaç yükleme kapasitesi gösterirler. İlaç yüklemesinin büyük ölçüde polimer matrisinin yüzeyinde gerçekleşmediği iki bileşenli elektroçekim olan geleneksel elektroçekim ile karşılaştırıldığında, çekirdek kabuklu nanofiberler, ilacın çekirdek katmana yüklenmesi nedeniyle gecikmeli salım ve patlama salınımında azalma gösterir. Bu inceleme makalesinin amacı, ilaç yüklü iki bileşenli nanofiberlerin yapı çekirdeği-kabuğu, yan yana, içi boş nanofiberler ve ayrıca emülsiyon nanofiberlerindeki üretimini ve uygulamalarını eş eksenli nozullar kullanarak araştırmaktır. Ayrıca, çalışma koşulları ve polimer özellikleri gibi bu elektrospinning işleminin yanı sıra elde edilen nanoliflerin ilaç verme profilini etkileyen parametreler kısaca özetlenmiştir. Nanolifler üzerindeki sınırlı klinik çalışmalar tartışılmıştır. Sonunda, elektroçekim prosesindeki ilerlemeler için sorunlara, olasılıklara ve yeni yaklaşımlara ilişkin perspektifler de sunulmuştur.

Anahtar Kelimeler

Bi-component nanolif, Co-axial elektroçekim, Side-by-side elektroçekim, Nanofibröz iskele, İlaç salım uygulaması

Kaynakça

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