Investigation of Neurotoxic and Immunotoxic Effects of the Chinar (Platanus orientalis L.) Tree Leaf Infusion Against Ethanol Toxicity in Rats

Yıl 2020, Cilt: 10 Sayı: 2, 778 - 787, 01.06.2020

Abdulahad Doğan , Fatih Donmez , Abdulhamit Battal , Ali Aslan , Ozgur Ozan Anuk

https://doi.org/10.21597/jist.643987

Cited By: 3

Öz

In this study, immunotoxic and neurotoxic effects of leaf infusion of Platanus orientalis L. (PO) were investigated in rats ethanol-induced toxicity. Neurotoxic effects of ethanol were evaluated by measuring acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in rat brain tissue. Immunotoxic effects were evaluated by adenosine deaminase (ADA) and myeloperoxidase (MPO) biomarkers in rat liver, lung, erythrocyte and spleen tissues. Thirty male Wistar rats were divided into five groups after toxicity study. The groups are explained as follow: Control, Ethanol 20 %, Ethanol 20 % + Silymarin (10 mg kg-1), Ethanol 20 % + PO-20 mg mL-1 infusion and Ethanol 20 % + PO-60 mg mL-1 infusion. The results showed that AChE and BChE activities statistically decreased in the groups treated with PO leaf infusion. While there was a statistically significant decrease in ADA and MPO activities in liver tissue of groups treated with PO leaf infusion. Also, MPO activity of erythrocyte in ethanol group was significantlly increased according to silymarin and PO-60 groups. On the other hand, there was no statistically significant finding was found in lung and spleen tissues. It was concluded that the infusion prepared from P. orientalis leaves suppressed to ethanol-induced neurotoxicity and immunotoxicity.

Anahtar Kelimeler

Platanus orientalis, acetylcholinesterase, butyrylcholinesterase, adenosine deaminase, myeloperoxidase, ethanol

Destekleyen Kurum

Van Yuzuncu Yil University

Proje Numarası

TAP-2019-8183

Teşekkür

This study was financially supported by Van Yuzuncu Yil University Scientific Research Projects Department.

Kaynakça

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