Mikroakışkanların Biyomedikal Alanında Kullanımı

Yıl 2024, Cilt: 4 Sayı: 2, 56 - 64, 30.05.2024

Buse Ay , Ahmet Koluman

Öz

Mikroakışkanlar, sıvılar veya gazlar gibi akışkan maddelerin mikroskobik ölçekteki hareketi ve etkileşimleri üzerine odaklanır. Genel olarak 1-500 mikrometre arasında mikro ölçekli yapısına sahip olan bu cihazlar ve sistemler, sıvıları kontrol etmeyi ve işlemeyi sağlar. Mikroakışkan teknolojisi patojenler, biyobelirteçler, pestisit kalıntıları, gazlar ve havadan yayılan mikroorganizmalar gibi çeşitli maddeleri tespit etmek için güçlü bir araç olarak ortaya çıkmıştır. Mikroakışkan cihazların tespiti, analit konsantrasyonlarını mikrometre düzeyinde ölçerek veya bir analitin basit varlığını veya yokluğunu belirleyerek anahtar bir özelliktir.
Mikroakışkan sistemlerde, çeşitli analitlerin tespiti, elektrokimyasal, optik, manyetik ve termal yöntemler gibi farklı fiziksel prensipleri kullanan çeşitli birleştirilmiş modüller aracılığıyla gerçekleştirilebilir. Bu entegrasyon modüllerinin çok yönlülüğü, araştırmacılara biyomedikal, klinik, çevresel izleme ve gıda güvenliği alanlarında çeşitli uygulama gereksinimlerine uygun tespit stratejileri geliştirmelerini sağlar. Mikroakışkan sistemlerin faydaları, enfeksiyon hastalıklarının tanımlanması için hızlı tespit, kullanım kolaylığı, maliyet etkinliği ve yüksek doğruluk içerir.
Bu incelemede, mikroakışkan sistemlerdeki tespit yöntemlerinin kullanımı ve biyomedikal, klinik, çevresel izleme, gıda güvenliği ve bakım noktası tanıları gibi çeşitli alanlardaki uygulamaları kapsamlı bir şekilde incelenmektedir.

Anahtar Kelimeler

Mikroakışkan, Tespit, Elektrokimyasal Tespit, Optik Tespit, Manyetik Tespit, Biyomedikal, Klinik, Gıda Güvenliği, Çevresel İzleme, Hasta odaklı Tanı.

Microfluidic Technology for Detection

Öz

Microfluidics focuses on the movement and interactions of fluidic substances, such as liquids or gases, on a microscopic scale. In general, it provides controls and handles fluids by utilizing devices and systems that possess microscale structures within 1-500 micrometers. Microfluidic technology has emerged as a powerful tool for detecting various substances, including pathogens, biomarkers, pesticide residues, gases, and airborne microorganisms. Detection is a key aspect of microfluidic devices by quantifying analyte concentrations on the order of micrometers or determining the mere absence or presence of an analyte.
In microfluidic systems, the detection of various analytes can be achieved through various integrated modules that utilize different physical principles, including electrochemical, optical, magnetic, and thermal methods. The versatility of these integration modules enables researchers to develop their detection strategies to suit diverse application requirements in biomedical, clinical, environmental monitoring, and food safety fields. The benefits of microfluidic systems include rapid detection, ease of use, cost-effectiveness, and high accuracy for the identification of infectious diseases.
In this review, the utilization of detection methods within microfluidic systems and their applications across various domains, including biomedical, clinical, environmental monitoring, food safety, and point-of-care diagnostics, are being extensively explored.

Anahtar Kelimeler

Microfluidics, Detection, Electrochemical detection, Optical detection, Magnetic detection, Biomedical, Clinical, Food Safety, Environmental Monitoring, Point-of-care Diagnostic

Kaynakça

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