Ülseratif kolitte hastalık aktivitesini değerlendirmede ortalama trombosit hacmi ile nötrofil-lenfosit oranı ve platelet-lenfosit oranlarının değerlendirilmesi

Yıl 2020, Cilt: 1 Sayı: 2, 28 - 33, 28.06.2020

Fatih Kamış , Ece Çetin Mücahit Ugar Yavuz Beyazıt

Öz

Amaç: Ülseratif kolit (ÜK) hastalarında hastalık aktivitesini değerlendirmek için serum ve gayta belirteçleri sıklıkla kullanılmaktadır. Ancak bu belirteçlerden hiçbiri hastalık aktivitesini göstermede yeterli spesifite ve sensitiviteye sahip değildir. Bu sebeple ÜK hastalarında hastalık aktivitesini belirlemede kullanılabilecek basit, maliyet-etkin ve kolay uygulanabilir laboratuvar testlerine olan ihtiyaç her geçen gün artmaktadır. Bu çalışma ÜK hastalarında aktiviteyi tahmin etmede ortalama trombosit hacmi (MPV), platelet lenfosit oranı (PLO) ve nötrofil-lenfosit oranının (NLO) kullanışlı olup olmadığını belirlemek için planlandı. Bununla birlikte MPV, PLO ve NLO’nun ÜK’daki diğer inflamatuar belirteçlerle olan ilişkisinin varlığı da araştırıldı.
Gereç ve Yöntem: Bu çalışmaya 63 aktif ÜK, 68 remisyondaki ÜK hastası ve 34 sağlıklı birey kontrol grubu olarak dahil edildi. Hastalık aktivitesi Truelove-Witts kriterlerine uygun olarak belirlendi. Hasta yaşı, cinsiyeti, inflamatuar belirteçler ve tam kan sayımı değerleri her hasta için kaydedildi.
Sonuçlar: Aktif ÜK grubunda NLO ve PLO değerleri remisyondaki ÜK ve kontrol grubu ile kıyaslandığında belirgin bir şekilde yüksek idi. Aktif ve remisyondaki ÜK grubunda NLO ortalamaları sırasıyla 2,8±1,7 ve 2,1±1,3, PLO ortalamaları ise sırasıyla 177,1±85,5 ve 137,9±64,0 idi. MPV düzeyleri aktif ÜK grubunda remisyondaki ÜK grubuna gore anlamlı bir şekilde düşük idi (p=0,044). Korelasyon analizinde NLO ve PLO hem CRP ve hem ESR ile korele olarak saptandı.
Tartışma: Bu çalışmada aktif ÜK hastalarında artmış NLO ve PLO ile azalmış MPV düzeyleri saptandı. Periferik kanda kolaylıkla ölçülebilecek MPV, NLO ve PLO gibi ölçümlerle ÜK hastalarında hastalık aktivitesi saptanabilir ve bulgu intestinal inflamasyonu değerlendirmede ek katkılar sağlayabilir.

Anahtar Kelimeler: Ortalama trombosit hacmi, platelet-lenfosit oranı, nötrofil-lenfosit oranı, ülseratif kolit

Anahtar Kelimeler

Ortalama trombosit hacmi, platelet-lenfosit oranı, nötrofil-lenfosit oranı, ülseatif kolit

Kaynakça

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