Evaluation of clinicopathological and prognostic significance of RDW in gastric cancer

Yıl 2022, Cilt: 3 Sayı: 1, 7 - 15, 24.03.2022

Dursun Burak Özdemir , Ahmet Karayiğit , Hayrettin Dizen , Bülent Ünal

https://doi.org/10.47582/jompac.1054490

Öz

Objective: We aimed to reveal possible relationships between pre-operative RDW values and clinicopathological features of gastric cancer (GC) and to evaluate its predictive impact on progression and prognosis of GC.
Material And Method: A total of 92 patients who underwent curative surgery were retrospectively included the study. GC patients were divided into two groups: high-RDW group (>14.5%, n=58) and low-RDW (<14.5%, n=34).
Results: The optimal pre-operative RDW cut-off value to predict mortality in GC patients was 14.5% (AUC=0.690, p=0.010). Increased tumor size and decreased albumin and hemoglobin values were found in the high-RDW group (p=0.036, 0.003 and <0.001, respectively). The 5-year overall survival (OS) rates were 17.6±5% in patients with high-RDW and 44.5±9% in the low-RDW group (p<0.001). Cox regression analysis showed perineural invasion, surgical margin positivity, N3 stage, leakage and high RDW were independent prognostic factors for mortality.
Conclusion: Our results indicate that RDW is associated with GC pathogenesis and tumor progression. Pre-operative RDW may be a non-invasive, easily accessible and reliable indicator to predict survival in patients with GC.

Anahtar Kelimeler

Gastric cancer, Red cell distribution width, RDW, prognosis, overall survival

RDW'nin mide kanserinde klinikopatolojik ve prognostik öneminin değerlendirilmesi

Öz

Amaç: Preoperatif RDW değerleri ile mide kanseri (MK)’nin klinikopatolojik özellikleri arasındaki olası ilişkileri ortaya koymayı ve MK’nin progresyonu ve prognozu üzerindeki prediktif etkisini değerlendirmeyi amaçladık.
Gereç ve Yöntem: Küratif cerrahi uygulanan toplam 92 hasta retrospektif olarak çalışmaya dahil edildi. MK hastaları iki gruba ayrıldı: yüksek RDW grubu (>%14,5, n=58) ve düşük RDW (<%14,5, n=34).
Bulgular: MK hastalarında mortaliteyi öngörmek için optimal preoperatif RDW eşik değeri %14,5 idi (AUC=0,690, p=0,010). Yüksek RDW grubunda tümör boyutunda artış, albümin ve hemoglobin değerlerinde azalma saptandı (sırasıyla p=0,036, 0,003 ve <0,001). Yüksek RDW’li hastalarda 5 yıllık genel sağkalım (OS) oranları %17,6±%5 ve düşük RDW grubunda %44,5±%9 idi (p<0,001). Cox regresyon analizi perinöral invazyon, cerrahi sınır pozitifliği, N3 evresi, sızıntı ve yüksek RDW değerinin mortalite için bağımsız prognostik faktörler olduğunu gösterdi.
Sonuç: Sonuçlarımız, RDW’nin MK patogenezinde ve tümör progresyonunda rol oynadığını göstermektedir. Preoperatif RDW, MK’li hastalarda sağkalımı öngörmek için invazif olmayan, kolay erişilebilir ve güvenilir bir gösterge olabilir.

Anahtar Kelimeler

Mide kanseri, Eritrosit dağılım genişliği, RDW, Prognoz, Genel sağkalım

Kaynakça

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