Effect of vitamin D deficiency on uric acid/HDL cholesterol ratio

Yıl 2024, Cilt: 5 Sayı: 3, 177 - 181, 28.06.2024

Ülkem Şen Uzeli , Ayşe Gülşen Doğan

https://doi.org/10.47582/jompac.1486189

Öz

Aims: It has been suggested that vitamin D deficiency is involved in the etiology of cardiovascular diseases. High uric acid and low HDL cholesterol levels are critical risk factors for cardiovascular diseases. High uric acid levels, high total cholesterol and triglyceride levels, and low HDL-C levels are often encountered in cases with vitamin D deficiency. Our study aimed to investigate the relationship between vitamin D levels and uric acid /HDL-C (UHR) and plasma atherogenic index (PAI, triglyceride /HDL-C) in patients with vitamin D deficiency.
Methods: This retrospective study included patients whose vitamin D levels were checked in our clinic. The subjects were divided into two groups according to their vitamin D levels and the relationship between laboratory variables, such as uric acid, HDL cholesterol, UHR, and plasma atherogenic index, was examined.
Results: A total of 675 patients, 167 (24.7%) males and 508 (75.3%) females, were included in the study. The mean age of the patients was 53.6±15.2 years. It was found that patients with vitamin D deficiency had high UHR and PAI levels and low HDL-C levels (p=0.001, p=0.025; p=0.032, p=0.016).
Conclusion Our results suggest that vitamin D deficiency has a positive correlation with HDL cholesterol levels and an impact on the risk of cardiovascular diseases by increasing the uric acid/HDL ratio and plasma atherogenic index.

Anahtar Kelimeler

Vitamin D, Uric Acid/HDL Cholesterol Ratio, plasma atherogenic index

D vitamini eksikliğinin ürik asit/HDL-kolesterol oranı üzerine etkisi

Öz

Giriş: Kalp damar hastalıklarının etiyolojisinde d vitamini eksikliğinin de yer aldığı öne sürülmektedir. Yüksek ürikasit düzeyi, düşük HDL-kolesterol düzeyleri kardiyovasküler hastalıklar için önemli birer risk faktördür. D vitamini eksikliğinde ürikasit yüksekliğine, total kolesterol, trigliserit seviyelerinde yüksekliğe ve düşük HDL-K düzeyi ile karşılaşılmaktadır. Biz de çalışmamızda d vitamini eksik olan hastaların D vitamini düzeyleri ile ürikasit /HDL-K(UHR) ve plazma aterojenik indeks (PAI, trigliserit/HDL-K) arasındaki ilişkiyi incelemeyi amaçladık.
Metod: Çalışmamız retrospektif bir çalışma olup kliniğimizde D vitamini düzeyi bakılan hastalar dahil edildi. Denekler D vitamini düzeylerine göre iki gruba ayrılarak ürik asit, HDL-kolesterol, UHR, plazma aterojenik indeks gibi laboratuvar değişkenleri ile arasındaki ilişki incelendi.
Sonuç: Çalışmada 167 (%24,7) erkek ve 508 (%75,3) kadın olmak üzere toplam 675 hasta dahil edildi. Hastaların yaş ortalaması 53,6±15,2 yıl idi. D vitamini eksik olan hastaların UHR ve PAI düzeylerinin yüksek olduğu, HDL-K düzeylerinin ise düşük olduğu görüldü (p=0,001, p=0,025; p=0,032, p=0,016).
Tartışma: Çalışmamız d vitamini eksikliğinin HDL-Kolesterol düzeyi ile pozitif bir korelasyon olduğu ürikasit /HDL oranını ve plazma aterojenik indeksi artırarak kardıyovasküler hastalık riskini üzerinde etkisi olduğu desteklemektedir.

Anahtar Kelimeler

d vitamini, ÜRİKASİT/HDL-KOLESTEROL ORANI, plazma aterojenik indeksi

Kaynakça

• Sempos CT, Heijboer AC, Bikle DD, et al.. Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D. Br J Clin Pharmacol.2018;84(10):2194-2207.
• Khazai N, Judd SE, Tangpricha V. Calcium and vitamin D: skeletal and extraskeletal health. Curr Rheumatol Rep.2008; 10:110-117.
• Holick MF. Vitamin D deficiency N. Engl J Med. 2007; 357: 266–281 doi: 10.1056. NEJMra070553.
• Mandarino NR, Junior F, Salgado JV, Lages JS, Filho NS. Is vitamin D deficiency a new risk factor for cardiovascular disease? Open Cardiovasc Med J.2015;9:40.
• Pludowski P, Holick MF, Pilz S, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality—a review of recent evidence. Autoimmun Rev. 2013;12(10):976-989.
• Gholami F, Moradi G, Zareei B, et al. The association between circulating 25-hydroxyvitamin D and cardiovascular diseases: a meta-analysis of prospective cohort studies. BMC Cardiovasc Disord. 2019;19(1):248. doi:10.1186/s12872-019-1236-7
• Tınazlı M, Cerit L. Hyperuricemia and Fragmented QRS. 14th International Congress of update in cardiology and cardiovascular surgery. Am J Cardiol 2018;121(8):67-68
• Doğantekin A. D vitamini eksikliğinde serum ürik asit düzeylerinin araştırılması . Firat Univ Sag Bil Tip Derg. 2022;36(1):31.
• Bonakdaran S, Varasteh AR. Correlation between serum 25 hydroxy vitamin D3 and laboratory risk markers of cardiovascular diseases in type 2 diabetic patients. Saudi Med J 2009;30(4):509-514.
•  Chien KL, Hsu HC, Chen PC, et al. Total 25-hydroxyvitamin D concentration as a predictor for all-cause death and cardiovascular event risk among ethnic Chinese adults: A cohort study in a Taiwan community. PLoS One 2015;10(3):e0123097
• Isnuwardana R, Bijukchhe S, Thadanipon K, Ingsathit A, Thakkinstian A. association between vitamin D and uric acid in adults: a systematic review and meta-analysis. Horm Metab Res. 2020;52(10):732-741. doi:10.1055/a-1240-5850
• Mehtap T, Nuriye S, Meryem G, Deniz S. Kuzey Kıbrıs yetişkinlerinde D vitamini ve ürik asit arasindaki ilişki: Birinci Ön Hazirlik Raporu. İstanbul Tıp Fak Derg. 2022;85(4):564-571.
• Jorde R, Figenschau Y, Hutchinson M, Emaus N, Grimnes G. High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile. Eur J Clin Nutr. 2010;64: 1457–1464.
• Gaddipati VC, Bailey BA, Kuriacose R, Copeland RJ, Manning T, Peiris AN. The relationship of vitamin D status to cardiovascular risk factors and amputation risk in veterans with peripheral arterial disease. J Am Med Dir Assoc. 2011.;12(1):58–61. 10.1016/j.jamda.2010.02.006
• Frohlich J, Dobiasova M. Kolesterolün fraksiyonel esterifikasyon hızı ve trigliseritlerin HDL-kolesterol oranı, koroner anjiyografideki pozitif bulguların güçlü belirleyicileridir . Klinik Kimya . 2003; 49(11):1873–1880
• Bonakdaran S, Varasteh AR. Correlation between serum 25 hydroxy vitamin D3 and laboratory risk markers of cardiovascular diseases in type 2 diabetic patients. Saudi Med J. 2009;30(4): 509-514.
• Wang L, Song Y, Manson JE, et al. Circulating 25-hydroxyvitamin D and risk of cardiovascular disease: A meta-analysis of prospective studies. Circ Cardiovasc Qual Outcomes.2012;5:819 -829.
• Ko J, Kang HJ, Kim DA, et al. Uric acid induced the phenotype transition of vascular endothelial cells via induction of oxidative stress and glycocalyx shedding. FASEB J. 2019;33(12):13334-13345. doi:10.1096/fj.201901148R
• Nagao M, Nakajima H, Toh R, Hirata KI, Ishida T. Cardioprotective effects of high-density lipoprotein beyond its anti-atherogenic action. J Atheroscler Thromb. 2018;25(10):985-993. doi:10.5551/jat.RV17025
• Hu X, Liu J, Li W, et al. Elevated serum uric acid was associated with pre-inflammatory state and impacted the role of HDL-C on carotid atherosclerosis. Nutr Metab Cardiovasc Dis. 2022; 32(7):1661-1669. doi:10.1016/j.numecd.2022.03.026
• Yang Y, Zhang J, Jia L, Su J, Ma M, Lin X. The interaction between uric acid and high-density lipoprotein cholesterol on the prognosis of patients with acute myocardial infarction. Front Cardiovasc Med. 2023;10:1226108. doi:10.3389/fcvm. 2023; 1226108
• Lupton JR, Faridi KF, Martin SS, et al. Deficient serum 25-hydroxyvitamin D is associated with an atherogenic lipid profile: The Very Large Database of Lipids (VLDL-3) study. J Clin Lipidol. 2016;10(1):72-81. doi:10.1016/j.jacl.2015.09.006
• Mashahit M, Elsayed A, Eltoukhy H. Influence of vitamin D level on diabetic dyslipidemia. AJMAH. 2017;7:1-1.
• Ray Chaudhuri J, Mridula KR, Anamika A, et al. Deficiency of 25-hydroxyvitamin D and dyslipidemia in Indian subjects. J Lipids. 2013;2013:623420. doi: 10.1155/2013/623420
• Wang H, Xia N, Yang Y, Peng DQ. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. doi:10.1186/1476-511X-11-42
• Jorde R, Grimnes G. Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids. Prog Lipid Res. 2011;50(4):303-312. doi:10.1016/j.plipres.2011.05.001
• Han Y, Han K, Zhang Y, Zeng X. Serum 25-hydroxyvitamin D might be negatively associated with hyperuricemia in U.S. adults: an analysis of the National Health and Nutrition Examination Survey 2007-2014 [published correction appears in J Endocrinol Invest. 2022 Apr;45(4):907. doi: 10.1007/s40618-021-01734-x]. J Endocrinol Invest. 2022;45(4):719-729. doi:10.1007/s40618-021-01637-x
• Peng H, Li H, Li C, Chao X, Zhang Q, Zhang Y. Association between vitamin D insufficiency and elevated serum uric acid among middle-aged and elderly Chinese Han women. PLoS One. 2013;8(4):e61159. doi:10.1371/journal.pone.0061159
• Nimitphong H, Saetung S, Chailurkit LO, Chanprasertyothin S, Ongphiphadhanakul B. Vitamin D supplementation is associated with serum uric acid concentration in patients with prediabetes and hyperuricemia. J Clin Transl Endocrinol. 2021;24:100255. doi:10.1016/j.jcte.2021.100255
• Han Y, Zhang Y, Zeng X. Assessment of causal associations between uric acid and 25-hydroxyvitamin D levels. Front Endocrinol (Lausanne). 2022 Dec 13;13:1024675. doi: 10.3389/fendo.2022.1024675
• Nagao M, Nakajima H, Toh R, Hirata KI, Ishida T. Cardioprotective effects of high-density lipoprotein beyond its anti-atherogenic action. J Atheroscler Thromb. 2018;25(10):985-993. doi:10.5551/jat.RV17025
• Manandhar B, Cochran BJ, Rye KA. Role of high-density lipoproteins in cholesterol homeostasis and glycemic control. J Am Heart Assoc. 2020;9(1):e013531. doi:10.1161/JAHA.119.013531
• Ko J, Kang HJ, Kim DA, et al. Uric acid induced the phenotype transition of vascular endothelial cells via induction of oxidative stress and glycocalyx shedding. FASEB J. 2019;33(12):13334-13345. doi:10.1096/fj.201901148R
• Mahmoodi MR, Najafipour H. Associations between serum vitamin D3, atherogenic indices of plasma and cardiometabolic biomarkers among patients with diabetes in the KERCADR study. BMC Endocr Disord. 2022;22(1):126. doi:10.1186/s12902-022-01043-1
• Amirkhizi F, Khademi Z, Hamedi Shahraki S, Rahimlou M. Vitamin D insufficiency and its association with adipokines and atherogenic indices in patients with metabolic syndrome: A case-control study. Front Endocrinol (Lausanne). 2023;14:1080138. doi:10.3389/fendo.2023.1080138