Mineralization of Hydrochlorothiazide using Hydrogen Peroxide in Subcritical Water

Yıl 2018, Cilt: 5 Sayı: 3, 1135 - 1144, 01.09.2018

Erdal Yabalak , Özkan Görmez Yahya Nural

https://doi.org/10.18596/jotcsa.449979

Cited By: 1

Öz

In this paper, we investigated the mineralization
of hydrochlorothiazide, a diuretic drug which is used for the treatment of
hypertension, using H₂O₂ as the oxidizing agent in
subcritical water as a medium. Response surface methodology was applied to
optimize experimental parameters such as temperature, treatment time, and
concentration of the oxidizing agent. 85.22% of TOC removal was obtained at 403
K, 80 mM of hydrogen peroxide and 147.3 min. The reliability of the performed
method was evaluated by ANOVA and the theoretical equation of TOC removal of hydrochlorothiazide
was proposed. F and p values of the model were determined as
62.88 and lower than 0.0001, respectively.  

Anahtar Kelimeler

Hydrochlorothiazide, Degradation, Subcritical water, Hydrogen peroxide, Response surface methodology

Kaynakça

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