18-28 YAŞ ARASI POLİKİSTİK OVER SENDROMLU HASTALARDA KANDA İRİSİN SEVİYESİNİN DEĞERLENDİRİLMESİ

Yıl 2023, Cilt: 2 Sayı: 1, 22 - 30, 30.04.2023

Hülya Toklucu , Paşa Uluğ , Ümit Arslan Naykı , Nesrin Yılmaz

Öz

Amaç: Son yıllarda polikistik over sendromu (PKOS) etiyopatogenezinde insülin direncinin rolünün ortaya konmuş ve obezite, tip 2 diabetes mellitus, hipertansiyon, dislipidemi, iskemik kalp hastalıkları, obstruktif uyku apnesi, endometrium kanseri ve mood bozuklukları gibi uzun dönem sağlık riskleriyle ilişkisi gösterilmiştir. İrisin ise yeni tanımlanmış bir myokin olup, insülin direnci ve metabolik sendromla ilişkili bulunmuştur. Biz bu çalışmamızda 18-28 yaş arası PKOS’lu olan ve olmayan gruplarda klinik, biyokimyasal, hormonal parametrelerle serum irisin düzeylerini karşılaştırdık.
Gereç ve Yöntem: Erzincan Binali Yıldırım Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum polikliniğine başvuran 18-28 yaş arası, Rotterdam 2003 kriterlerine göre PKOS tanısı alan 64 hasta ve 60 kontrol grubu çalışmaya dahil edildi. Hastalara pelvik ultrasonografi yapıldı. Kilo, boy, tansiyon ölçüldü. HDL, LDL, trigliserid, total kolesterol, açlık insulin, LH, FSH, estradiol, total testesteron, serbest testesteron, homosistein, CRP, TSH, prolaktin, açlık glukoz, DHEAS, AMH, ALT, AST, HbA1c ve irisin düzeylerine bakıldı. Vücut kitle indeksleri ve HOMA-IR değerleri hesaplandı.

Bulgular:PKOS’lu hastalar ve kontrol grubu klinik özellikler açısından karşılaştırıldığında her iki grup arasında yaş, boy, HDL, trigliserit, açlık insulin, FSH, LH, estradiol, TSH, prolaktin, ALT, AST, HOMA-IR indeks arasında istatistiksel olarak anlamlı bir fark izlenmedi. Kilo, vücut kitle indeksi, tansiyon, LDL, total kolesterol, total testesteron, serbest testesteron, homosistein, CRP, açlık glukoz, DHEAS, HbA1c değerleri açısından PKOS grubundaki hastalarda istatistiksel anlamlı olarak daha yüksek izlendi (p<0,05). İrisin düzeyleri PKOS grubundaki hastalarda istatistiksel anlamlı olarak daha düşük izlendi (p<0,05).
Sonuç: PKOS hasta grubunda irisin düzeyleri kontrol grubuna göre istatistiksel anlamlı olarak daha düşük bulunmuştur.

Anahtar Kelimeler

Polikistik over sendromu, irisin, insulin direnci, ileri dönem risk

Destekleyen Kurum

Erzincan Binali Yıldırım Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Proje Numarası

TTU-2017-494

Teşekkür

Bu yayına mali destek sağlayan Erzincan Binali Yıldırım Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimine mali katkılarından dolayı teşekkür ederiz.

EVALUATION OF IRISIN LEVELS IN BLOOD IN PATIENS WITH POLYCYSTIC OVARY SYNDROME AGED BETWEEN 18-28 YEARS

Öz

Objective: Women with polcystic ovary syndrome (PCOS) show high levels of insulin resistance and compensatory hyperinsulinemia compared to unaffected women. It has recently been shown that insulin resistance plays a role in the ethiopathogenesis of PCOS and it has also been shown lately that it is related with long term health risks such as obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and ischemic heart disease, obstructive sleep apnea syndrome, endometrium cancer and mood disorders. Irisin , a newly identified myokine, has been shown to be associated with insulin resistance and metabolic syndrome.The purpose of this study was to determine and compare the serum levels of irisin in PCOS patients and the control groups and thereas to predict their long term health risks such as the increased metabolic syndrome and cardiovasculer risk.
Material and Methods: 64 patients with PCOS diagnosed according to Rotterdam 2003 criteria and 60 healthy controls who admitted to Erzincan Binali Yıldırım University Obstetrics and Gynecology out-patient clinics between 18-28 years in age were enrolled. Pelvic ultrasounds were performed during a gynecological examination. Height, weight, blood pressure were measured. Fasting glukoz, fasting insulin, total cholesterol, LDL, HDL, trigliserid, total testosterone, FSH, LH, estradiol,free testesteron, homosistein, CRP, TSH, prolactin, DHEAS, ALT, AST, HbA1c and irisin levels were measured. Patients were evaluated for hirsutism according to the Ferriman Gallwey scoring system. HOMA-IR values were calculated.

Results: When the patients withPCOS and control group were compared in terms of clinical features, there was no statistically significant difference between the two groups in terms of age, height, HDL, TG, fasting insulin, FSH, LH, estradiol, TSH, prolactin, ALT, AST, HOMA-IR index. There was statistically significant difference between two groups in term of weight,body mass index, blood pressure, LDL, total cholesterol, total testesteron, free testesteron, homosistein, CRP, fasting glucose, DHEAS, HbA1c (p<0,05). The irisin levels in the PCOS group were statistically significantly lower than the control group.
Conclusion: In our research the irisin levels in the PCOS group were statistically significantly lower than the control group.

Anahtar Kelimeler

Polikistik over sendromu, irisin, insulin direnci, ileri dönem risk

Proje Numarası

TTU-2017-494

Kaynakça

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