MEMENİN TAŞLI YÜZÜK HÜCRELİ KARSİNOMU

Yıl 2018, , 79 - 81, 23.07.2018

Serkan Akın

https://doi.org/10.18229/kocatepetip.345682

Öz

AMAÇ: Memenin taşlı yüzük hücreli karsinomu agresif klinik
gidişatı olan nadir bir alt gruptur. Meme kanserlerinin %2-4.5’ini oluştururlar.
Bu çalışmada taşlı yüzük hücreli meme kanseri olgularının klinik ve patolojik
özelliklerini analiz ettik.

GEREÇ VE
YÖNTEM: 2007-2014 tarihleri arasında Hacettepe Üniversitesi
Kanser Enstitüsü’nde meme kanseri tanısı alan ve tedavi edilen 3587 hastaya ait
veriler incelendi. Hastaların demografik özellikleri ve patoloji raporları,
klinik sonuçlarla birlikte değerlendirildi.

BULGULAR: Taşlı yüzük hücreli meme karsinomu olan 25 hasta
bulundu (%1). Ortanca yaşları 53 olan bu hasta grubunun %48’i premenapozal
dönemde tanı almıştı. Tanı anında 4 hastanın metastatik, diğer 21 hastanın ise
lokal hastalığı vardı.  Tümörler genellikle grade 2, ER pozitif ve HER2 negatif
idi. Mikst histoloji tespit edilen hastalardan 9’unda invaziv duktal karsinom,
6’sında invaziv lobüler karsinom eşlik etmekteydi. Ortalama takip süresi 27 ay
idi. Yedi hastada nüks gözlendi (1 lokal, 1 hem lokal hem uzak, 5 uzak). Kemik,
karaciğer ve overler en sık uzak nüks saptanan organlar idi (sırasıyla 3, 2 ve
2).

SONUÇ: Bu çalışmada, taşlı yüzük hücreli meme karsinomu
prevalansı literatürden daha düşük olarak bulunmuştur (%0.7). İnvaziv duktal
karsinom en sık eşlik eden tiptir. Uzak nüksü olan 7 hastadan 2’sinde tutulan
organ overdir. Taşlı yüzük hücreli karsinom olgularında over metastazı ile
karşılaşılabilir.

Anahtar Kelimeler

Taşlı yüzük hücreli karsinom, meme kanseri, metastaz

SIGNET RING CELL CARCINOMA OF BREAST

Öz

OBJECTIVE: Signet ring cell carcinoma
(SRCC) of breast is a rare subtype with aggressive clinical course. The
prevalence of signet ring features is between 2 to 4.5% of total breast
cancers. Here we analyzed clinical and pathological features and outcomes of
our patients with SRCC of breast.

MATERIALS AND
METHODS: We investigated
retrospectively medical charts of 3587 patients with breast cancer diagnosed
and treated in Hacettepe University Cancer Institute between 2007-2014. Patient
demographics, pathology reports were assessed along with clinical outcomes.

RESULTS: Twenty five patients with
SRCC were identified (1%) Median age was 53 years and 48% of them were
premenopausal. At initial diagnosis, metastatic disease was seen in 4 patients,
other 21 patients have localized disease. Tumors were mostly grade 2, ER
positive and Her2 negative. In patients with mixed histology, co-existed
histology was invasive ductal carcinoma in 9 patients and invasive lobular
carcinoma in 6 patients.  Median follow
up was 27 months. Seven patients had recurrence (1 local, 1 both local and
distant, 5 distant). Most common site of distant relapses were bone, liver and
ovaries (3, 2 and 2 patients, respectively).

CONCLUSION: In this study, the prevalence of
SRCC was found 0.7 %, which is lower than that reported in the literature.
Invazive ductal carcinoma is the most common accompanying subtype. Ovarian
metastases were found in 2 of 7 distant failures. Signet ring cell histology
may have a predilection for ovarian metastases.

Anahtar Kelimeler

Signet ring cell carcinoma, breast cancer, metastasis

Kaynakça

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