ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ

Yıl 2017, Cilt: 18 Sayı: 1, 7 - 12, 17.01.2017

Ömer Ateş

https://doi.org/10.18229/kocatepetip.343171

Öz

AMAÇ: Alopesi Areata patogenezinde, değiş-
miş T hücre aracılı bağışıklığın rol aldığını gösteren
çok sayıda çalışma bulunmaktadır. Sitokinlerin
ve kemokinlerin Alopesi Areata’nın immun
sürecinde önemli rol oynamasından dolayı, Alopesi
Areata’ya yatkınlık ile TNF-α-308G/A polimorfizmi
arasındaki olası bağlantının Türk populasyonunda
araştırılması amacıyla bu çalışma
gerçekleştirildi.

GEREÇ VE YÖNTEM: Sunulan vaka kontrol çalışmasına
107 Alopesi Areata hastası ve 113
sağlıklı kontrol bireyi dahil edildi. TNF-α-308G/A
polimorfizminin genotiplendirmesi Polimeraz
Zincir Reaksiyonu (PZR) ve Restriksiyon Enzim
Analizi (REA) yöntemleri ile gerçekleştirildi.

BULGULAR: Hasta ve kontrol gruplarında
TNF-α-308 G/A genotiplerinin ve allel frekanslarının
dağılımı arasında anlamlı bir bağlantı
bulunamadı (p=0.673 ve p=0.177, sırasıyla).
Benzer şekilde, TNF-α-308 G/A polimorfizmi ile
Alopesi Areata’nın klinik bulguları arasında fark
tespit edilemedi.

SONUÇ: Bu çalışma, TNF-α-308 G/A polimorfizminin
Türk populasyonunda Alopesi Areata
gelişiminde önemli bir rol oynamadığını göstermektedir. 

Anahtar Kelimeler

Alopesi Areata, Polimorfizm, Genetik yatkınlık, TNF-α

Kaynakça

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