KRONİK OTOİMMÜN TİROİDİT VE NESFATİN-1 DÜZEYİ ARASINDAKİ İLİŞKİ

Yıl 2022, Cilt: 23 Sayı: 3, 339 - 343, 18.07.2022

Fatma Dilek Dellal , Mutlu Niyazoğlu Esra Hatıpoglu , Fatma Aksoy Halime Ünver Esranur Ademoğlu Yalçın Aral

https://doi.org/10.18229/kocatepetip.885143

Öz

AMAÇ: Bu çalışmanın amacı kronik tiroiditli hastalarda nesfatin-1 düzeyi ile tiroid otoimmünitesi arasındaki ilişkiyi değerlendirmektir.
GEREÇ VE YÖNTEM: Hashimoto tiroiditli 49 premenopozal kadın ve yaş ve vücut kitle indeksi (VKI) uyumlu 23 sağlıklı kadın, bu kesitsel karşılaştırmalı çalışmaya dahil edildi. Plazma nesfatin-1, açlık ve tokluk glukoz, hemoglobin A1c (HbA1c), açlık insülin, kolesterol parametreleri, serbest tiroksin (ST4), serbest T3 (ST3), tirotropin (TSH), anti-tiroid peroksidaz antikor (anti-TPO) and anti-tiroglobin (anti-TG) antikor değerleri için kan örnekleri alındı. Ek olarak tüm vakalarda, insülin direnci için homeostatik model değerlendirmesi (HOMA-İR) ve vücut kitle indeksi (VKİ) hesaplandı ve bel/kalça oranı ölçüldü.
BULGULAR: Hashimoto tiroiditli hastaların ortalama yaşı 35,5±8,1, kontrol grubunun ise 33,2±7,1 idi (p=0.324). VKI ve bel/kalça oranı, gruplar arasında benzerdi (p=0.239 ve p=0.317). TSH, anti-TPO ve anti-TG düzeyleri hasta grubunda anlamlı derecede yüksekti (p=0.023, p<0.001 ve p<0.001). Hastalarda trigliserid düzeyleri istatistiksel anlamlılık sınırında daha yüksekti(p=0.05). Her iki grup arasında nesfatin düzeyleri açısından istatistiksel anlamlı farklılık yoktu [0,4 (0,39-0,43), 0,39 (0,39-0,39) ng/ml;p=0.329].
SONUÇ: Kronik otoimmün tiroiditte tiroid hormon değişiklikleri ya da otoimmünite, nesfatin-1 düzeylerinde değişikliğe yol açmayabilir. Hashimoto tiroiditli hastalardaki tokluk ve enerji tüketiminden nesfatin-1 dışındaki mekanizmalar sorumlu olabilir.

Anahtar Kelimeler

Hashimoto tiroiditi, Kronik otoimmün tiroidit, Nesfatin, Tiroid stimulan hormon, Tiroid otoantikor

Teşekkür

Nesfatin-1 kitinin edinilmesinde finansal destek sağlaya Amgen İlaç Firması'na teşekkür ederiz.

ASSOCIATION BETWEEN CHRONIC AUTOIMMUNE THYROIDITIS AND NESFATIN-1 LEVELS

Öz

OBJECTIVE: The aim of this study was to evaluate relationship between nesfatin-1 levels and thyroid autoimmunity in cases with chronic thyroiditis.
MATERIAL AND METHODS: A total of 49 consecutive premenopausal women with Hashimoto’s thyroiditis and, age and body mass index (BMI)-matched 23 healthy female subjects were included in this cross-sectional comparative study. Levels of nesfatin-1, fasting and postprandial blood glucose, hemoglobin A1c (HbA1c), fasting insulin, cholesterol, free thyroxine (FT4), free triiodothyronine (FT3), thyrotropin (TSH), anti-thyroid peroxidase antibody (anti-TPO) and anti-thyroglobulin antibody (anti-TG) were obtained for all cases. Additionally homeostatic model assessment for insulin resistance (HOMA-IR) and BMI was calculated and waist-to-hip ratio (WHR) was measured for each case.
RESULTS: The mean age of the group with Hashimoto’s thyroiditis was 35.5±8.1 years and of the healthy controls was 33.2±7.1 years old (p=0.324). BMI and WHR were similar between the groups (p=0.239 and p=0.317). TSH, anti-TPO and anti-TG levels were significantly higher in cases with Hashimoto’s thyroiditis (p=0.023, p<0.001 and p<0.001). Triglyceride levels were higher in the patients with Hashimoto’s thyroiditis at the limit of statistical significance (p=0.05). Nesfatin levels were not different statistically in between two groups [0.4 (0.39-0.43) , 0.39 (0.39-0.39) ng/ml;p=0.329].
CONCLUSIONS: Alterations in thyroid hormones or autoimmunity in chronic autoimmune thyroditis may not alter nesfatin-1 levels. Different mechanisms, other than nesfatin-1, may be responsible for changes in satiety and energy expenditure in Hashimoto’s thyroiditis.

Anahtar Kelimeler

Hashimoto’s thyroditis, Chronic autoimmune thyroditis, Nesfatin, Thyroid stimulating hormone, Thyroid autoantibody.

Kaynakça

• 1. Kohno D, Nakata M, Maejima Y, et al. Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding. Endocrinology. 2008;149:1295-301.
• 2. Brailoiu GC, Dun SL, Brailoiu E, et al. Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain. Endocrinology. 2007;(148):5088-94.
• 3. Sawicka B, Bossowski A. Analysis of serum levels of nesfatin-1 in children and adolescents with autoimmune thyroid diseases. Pediatr Endocrinol Diabetes Metab. 2013; (19):5-10.
• 4. Oh IS, Shimizu H, Satoh T, et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature. 2006;(443):709-12.
• 5. Ademoglu EN, Gorar S, Carlioglu A, et al. Plasma nesfatin-1 levels are increased in patients with polycystic ovary syndrome. J Endocrinol Invest. 2014;37(8):715-9.
• 6. Deniz R, Gurates B, Aydin S, et al. Nesfatin-1 and other hormone alterations in polycystic ovary syndrome. Endocrine. 2012;(42):694-9.
• 7. Catak Z, Aydin S, Sahin I, et al. Regulatory neuropeptides (ghrelin, obestatin and nesfatin-1) levels in serum and reproductive tissues of female and male rats with fructose- induced metabolic syndrome. Neuropeptides. 2014;(48):167-77.
• 8. Zhai T, Li SZ, Fan XT, Tian Z, et al. Circulating Nesfatin-1 Levels and Type 2 Diabetes: A Systematic Review and Meta-Analysis. J Diabetes Res. 2017;2017:7687098.
• 9. Liu F, Yang Q, Gao N, Liu F, et al. Decreased plasma nesfatin-1 level is related to the thyroid dysfunction in patients with type 2 diabetes mellitus. J Diabetes Res. 2014;2014:128014.
• 10. Gungunes A, Ozbek M, Ginis Z, et al. Serum nesfatin-1 levels in overt and subclinical hyperthyroidism. Minerva Endocrinol. 2014;(39):209-14.
• 11. Hussien NI, Mousa AM, Shoman AA. Decreased level of plasma nesfatin-1 in rats exposed to cell phone radiation is correlated with thyroid dysfunction, oxidative stress, and apoptosis. Arch Physiol Biochem. 2020;(17):1-7.
• 12. Abbasalizad Farhangi M, Tajmiri S. The correlation between inflammatory and metabolic parameters with thyroid function in patients with Hashimoto’s thyroiditis: The potential role of interleukin 23 (IL-23) and vascular endothelial growth factor (VEGF)-1. Acta Endocrinol (Buchar). 2018;14(2):163-8.
• 13. Sahin SB, Ayaz T, Cure MC, et al. Association of nesfatin-1 levels with fasting and postload glucose levels in patients with hypothyroidism. J Exp Clin Med. 2014;31(4):217-20.
• 14. Atıci E, Mogulkoc R, Baltaci AK, Menevse E. The effect of thyroid dysfunction on nesfatin-1 and adiponectin levels in rats. Horm Mol Biol Clin Investig. 2017;32(3):20170033.
• 15. Tohma Y, Akturk M, Altinova A, et al. Circulating Levels of Orexin-A, Nesfatin-1, Agouti-Related Peptide, and Neuropeptide Y in Patients with Hyperthyroidism. Thyroid. 2015;25(7):776-83.
• 16. Xu YY, Liang J, Cao Y, et al. High levels of Nesfatin-1 in relation to the dysfunction of the hypothalamic-pituitary-adrenal and hypothalamus-pituitary-thyroid axes in depressed patients with subclinical hypothyroidism. Neuropsychiatr Dis Treat. 2017;(13):1647-53.
• 17. Kapali A, Beerappa J, Raghuram P, et al. Diagnostic accuracy of ultrasound imaging in Hashimoto's thyroiditis. Thyroid Res Pract. 2017;(14):28-31.
• 18. Bastard JP, Grimaldi A, Jardel C, et al. A simple index of insulin resistance. Diabetes Metab.1997;(23):87-8.
• 19. Orban Z, Bornstein SR, Chrousos GP. The interaction between leptin and the hypothalamic-pituitary-thyroid axis. Horm Metab Res. 1998;(30):231-5.
• 20. Price CJ, Hoyda TD, Samson WK, et al. Nesfatin-1 influences the excitability of paraventricular nucleus neurones. J Neuroendocrinol. 2008;(20):245-50.
• 21. Sawicka B, Bossowski A, Szalecki M, et al. Relationship between metabolic parameters and thyroid hormones and the level of gastric peptides in children with autoimmune thyroid diseases. J Pediatr Endocrinol Metab. 2010;(23):345-54.