Obezitenin Galanin ve Vaspin Düzeyleri ile İlişkisi

Yıl 2023, Cilt: 18 Sayı: 3, 29 - 36, 20.11.2023

Murat Takmet , Dilek Tüzün , Murat Şahin , Adem Doğaner , Metin Kılınç

https://doi.org/10.17517/ksutfd.1140097

Öz

Amaç: Amacımız obez ve normal kilolu bireylerde vaspin ve galanin düzeylerini karşılaştırmak, bu parametrelerin obezite ve diğer ilişkili parametrelerle ilişkili olup olmadığını ortaya çıkarmak.
Gereç ve Yöntemler: Çalışmaya obezitesi olan 40 hasta ve 40 kontrol alındı. Biyokimyasal parametreler hasta dosyalarından kaydedildi. Hastalardan alınan kan örneklerinin santrifüjlenmesi sonucu elde edilen örnekten galanin ve vaspin düzeyleri çalışıldı.
Bulgular: Gruplar cinsiyet ve yaş açısından birbirine benzerdi (p>0.05). Obezitesi olan grupta galanin düzeyleri kontrol grubuna göre daha yüksekti (p<0,001). Vaspin düzeyleri obezitesi olan grupta kontrol grubuna göre daha yüksekti ancak istatistiksel olarak anlamlı değildi (p>0.05). Hasta grubunda glukoz, insülin, trigliserit ve LDL-C düzeyleri kontrol grubuna göre istatistiksel olarak anlamlı derecede yüksekti (p<0,001). TSH açısından istatistiksel olarak anlamlı fark yoktu (p>0.05). Sırasıyla galanin ve glukoz, insülin ve BMI ile istatistiksel olarak anlamlı bir pozitif korelasyon bulundu (p<0.001, r=0.401; p<0.001, r=0.519; p<0.001, r=0.714). Ayrıca vaspin ile insülin, vücut kitle indeksi (VKİ) arasında sırasıyla istatistiksel olarak anlamlı pozitif korelasyon vardı (p=0.05,r=0.222;p=0.03, r=0.238).
Sonuçlar: Sonuçlarımız, obez kişilerde yüksek serum galanin ve vaspin konsantrasyonlarının kilo alımının bir sonucu olabileceğini veya obezitenin patogenezinde rol oynayan birçok faktörden biri olabileceğini göstermektedir.

Anahtar Kelimeler

Galanin, Vaspin, Obezite, Adipositokinler

Destekleyen Kurum

Kahramanmaraş Sütçü İmam Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Proje Numarası

2020/3-17 D

Relationship Between Obesity with Galanin and Vaspin Levels

Öz

Objective: Our aim was to compare vaspin and galanin in obese and normal weight individuals, to reveal whether these parameters are related to obesity and other related parameters.
Material and Methods: Forty patients with obesity and 40 control subjects were included in the study. Biochemical parameters were recorded from patient’s files. Galanin and vaspin levels were studied from the sample obtained as a result of centrifugation of blood samples taken from the patients.
Results: The groups were similar to each other in terms of gender and age (p>0.05). Galanine levels were higher in the group with obesity compared to the control group (p<0.001). Vaspin levels were higher in the group with obesity compared to the control group, but it was not statistically significant (p>0.05). Glucose, insulin, triglyceride and low-density lipoprotein cholesterol (LDL-C) levels were statistically significantly higher in the patient group than in the control group (p<0.001). There was no statistically significant difference in terms of thyroid stimulating hormone (TSH) (p>0.05). A statistically significant positive correlation was found with galanin, glucose, insulin, and body mass index (BMI), respectively (p<0.001, r=0.401; p <0.001, r=0.519; p <0.001, r=0.714). Also there was statistically significant positive correlation between vaspin and insulin, BMI, respectively (p=0.05, r=0.222; p=0.03, r=0.238).
Conclusion: Our results show that high serum concentrations of galanin and vaspin in obese subjects may be the result of weight gain or may be one of many factors involved in the pathogenesis of obesity.

Anahtar Kelimeler

Galanin, Vaspin, Obesity, Adipocytokines

Proje Numarası

2020/3-17 D

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