Evaluation of Oxidative Stress Parameters in Male Textile Workers Working in Different Sections of Production

Yıl 2024, Cilt: 19 Sayı: 3, 121 - 126, 04.11.2024

Leyla Dokumacı , Işıl Yağmur , Rabia Tural , Fatma İnanç Tolun , Hasan Dağlı , Yeliz Doboğlu , Hatice Sağer

https://doi.org/10.17517/ksutfd.1384493

Öz

Objective: Occupationally exposed environmental conditions and many substances threaten human health by causing diseases. This study examines biochemically how the oxidant and antioxidant system parameters change in the employees working in different textile departments.

Material and Methods:3 groups of 30 people were formed, each consisting of healthy men who do not smoke or drink alcohol, working in the office, dyehouse and yarn departments of a textile company in Kahramanmaraş office worker (control group, group 1), dyehouse worker (group 2), yarn worker (group 3). After 12 hours of fasting, venous blood samples were taken and serum samples were separated. Total oxidant status (TOS), total antioxidant status (TAS), total thiol [(-SH)+(-S-S-)] (TT), and native thiol [-SH] (NT) levels were measured spectrophotometrically, oxidative stress index (OSI) and disulfide [-S-S-] levels were calculated.

Results: There was no significant difference between the groups regarding TOS, TAS, OSI, TT, disulfide, and disulfide/NT values (p>0.05). Disulfide/TT levels in the dyehouse group according to the office group, NT and NT/TT levels in the yarn group according to the dyehouse group were found to be statistically significantly higher (p˂0.05).

Conclusion: It was concluded that it would be beneficial to take necessary precautions against all kinds of exposures that cause oxidative stress in the protection of employee health and to evaluate oxidative stress markers in periodic health screenings of employees.

Anahtar Kelimeler

Textile workers, Oxidative stress, Total oxidant level, Total antioxidant level, Thiol/disulfide balance

Proje Numarası

Proje No : 2019 / 2-28

Üretimin Farklı Bölümlerinde Çalışan Erkek Tekstil İşçilerinde Oksidatif Stres Parametrelerinin Değerlendirilmesi

Öz

Amaç: Mesleki olarak maruz kalınan ortam şartları ve birçok madde, hastalıklara neden olarak insan sağlığını tehdit etmektedir. Bu çalışmamızda tekstilde farklı bölümlerde çalışanlarda, oksidan ve antioksidan sistem parametrelerinin nasıl değiştiğinin biyokimyasal olarak incelenmesi amaçlanmıştır.
Gereç ve Yöntemler: Kahramanmaraş ilindeki bir tekstil firmasının ofis, boyahane ve iplik bölümlerinde çalışan sigara ya da alkol kullanmayan sağlıklı erkeklerden oluşan 30’ar kişilik 3 grup oluşturuldu; ofis çalışanı (kontrol grubu, grup 1), boyahane çalışanı (grup 2), iplik çalışanı (grup 3). 12 saatlik açlığı takiben venöz kan örnekleri alınarak serum örnekleri ayrıldı. Total oksidan durum (TOS), total antioksidan durum (TAS), total tiyol [(-SH)+(-S-S-)] (TT) ve nativ tiyol [-SH] (NT) düzeyleri spektrofotometrik olarak ölçüldü, oksidatif stres indeksi (OSİ) ve disülfit [-S-S-] düzeyleri hesaplandı.
Bulgular: Gruplar arasında TOS, TAS, OSİ, TT, disülfit ve disülfit/NT değerleri açısından anlamlı bir fark yoktu (p>0.05). Ofis grubuna göre boyahane grubunda disülfit/TT düzeyleri, boyahane grubuna göre iplik grubunda NT ve NT/TT düzeyleri istatistiksel olarak anlamlı derecede daha yüksek bulundu (p<0.05).
Sonuç: Çalışan sağlığının korunmasında oksidatif strese yol açan her türlü maruziyete karşı gerekli tedbirlerin alınmasının ve çalışanların periyodik sağlık taramalarında oksidatif stres belirteçlerinin de değerlendirilmesinin yararlı olacağı kanaatine varılmıştır.

Anahtar Kelimeler

Tekstil çalışanları, Oksidatif stres, Total oksidan seviye, Total antioksidan seviye, Tiyol/disülfid dengesi

Destekleyen Kurum

yok

Proje Numarası

Proje No : 2019 / 2-28

Kaynakça

• Kocabaş F, Aydın U, Canbey Özgüler V, İlhan MN, Demirkaya S, Ak N, et al. Relationship between psychosocial risk factors in the work place and work related diseaes, occupational dısease and work accident. Sosyal Güvence Dergisi. 2018;0(14):28-62.
• Tarım M. Personal injury and occupational diseases in chemical industry. Istanbul Commerce University Journal of Science. 2017;16(32):49-64.
• Şimşek B. Tekstil Sektörü İş Sağlığı ve Güvenliği. İSG Dergisi. 2009;42.
• Suryakar AN, Katkam RV, Dhadke VN, Bhogade RB. A study of oxidative stress in cotton industry workers from Solapurcity. Biomedical Research. 2010;21(3):260-264.
• Phaniendra A, Jestadi DB, Periyasamy L. Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases. Indian J Clin Biochem. 2015;30(1): 11–26.
• Süner A, Polat M, Sezen H, Şavik E, Kaya H, Köroğlu S. The effect of long-term smoking on oxidative stress. Journal of Harran University Medical Faculty. 2014;11(2):138-145.
• Ghiselli A Serafini M, Natella F, Scaccini C. Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Radic Biol Med. 2000;29(11):1106-1114.
• Erel O. A new automated colorimetric method for measuring total oxidant status. Clinical Biochemistry. 2005;38(12):1103-1111.
• Yazıcı S, Demirtaş S, Güçlü O, Karahan O, Yavuz C, Çalıskan A, et al. Using oxidant and antioxidant levels to predict the duration of both acut eperipheral and mesenteric ischemia. Perfusion. 2014;1–6.
• Yazar H, Yıldız E, Inci MB, Cakar MA, Ozbek B, Bal C, et al. An analysis of plasma thiol/disulphide homeostasis in patients with stable angina. Online Turkish Journal of Health Sciences. 2020;5(2):318-323.
• Erel Ö, Erdoğan S. Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects. Turk J Med Sci. 2020;50:1728-1738.
• Erel Ö, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clinical Biochemistry. 2014;47(18):326-332.
• Bayil S, Çiçek H, Geyikli Cimenci I, Hazar M. How volatile organic compound saffect free radical and antioxidant enzyme activity in textile workers. Arh Hig Rada Toksikol. 2008;59(4):283-287.
• Turan B. Cancer attributable to occupational exposures in textile industry. Journal of Medical Sciences. 2020;1(2):26-31.
• Shaker DA. Oxidative stress and immunoglobulin levels in workers exposed to cotton dust. Egyptian Journal of Occupational Medicine. 2012;36(1):107-121.
• Rahman T, Faisal A-R, Khanam T, Shekhar HU. Recurrent indoor environmental pollution and its impact on health and oxidative stress of the textile workers in bangladesh. Environ Health Insights. 2020;14.
• Yıldırım I, Kılınc M, Okur E, İnanç Tolun F, Kılıç MA, Belge Kurutas E, et al. The effects of noise on hearing and oxidative stress in textile workers. Ind Health. 2007;45(6):743-749.
• Havlioglu S, BegencTascanov M, Koyuncu I, Temiz E. The relation ship among noise, total oxidative status and DNA damage. Int Arch Occup Environ Health. 2022;95(4):849-854.
• Gündüzöz M, Bal C, Büyükşekerci M, Neşelioğlu S, Nadir Öziş T, İritaş S, et al. Evaluation of dynamic disulphide/thiol homeostasis in silica exposed workers. Balkan Med J. 2017;34:102-107.
• Athavale A, Iyer A, Sahoo D, Salgia K, Raut A, Kanodra N. Incidence of silicosis in flourmill workers. Indian Journal of Occupational and Environmental Medicine. 2011; 15(3).
• Palabıyık SS, Girgin G, Tutkun E, Yilmaz OH, Baydar T. Immunomodulation and oxidative stress in denim sandblasting workers: changes caused by silica exposure. Arh Hig RadaToksikol. 2013;64(3):431-437.
• Asoğlu M, Kılıçaslan F, Beginoğlu Ö, Fedai Ü, Akıl Ö, Çelik H, et al. Thiol/disulphide homeostasis as a new oxidative stress marker in untreated patients with generalized anxiety disorder. Anatolian Journal of Psychiatry. 2018;19(2):143-149.
• Büyükşekerci M, Gündüzöz M, Özakıncı OG, Karataş M, Şenat A, Neşelioğlu S, et al. Dynamic thiol/disulfide homeostasis as indicator of oxidative stress in automotive workers. Biomarkers. 2020;25(3):274-280.
• Özakıncı OG, Gündüzöz M, Buyuksekerci M, Karataş M, Balik AR, Neselioglu S, et al. Dynamic thiol disulfide homeostasis in painters as indices of oxidative stress. Int J Environ Health Res. 2022;32(5):1067-1075.
• Karakulak UN, Bal C, Gunduzoz M, Buyuksekerci M, Aladag E, Sahiner ML, et al. Assessment of diastolic function and thiol-disulphide homeostasis in arsenic-exposed workers. Acta Cardiol Sin. 2021;37(1):86–96.