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Candida auris Candidemia in Türkiye: First Case in Anatolia

Yıl 2025, Cilt: 20 Sayı: 1, 91 - 95
https://doi.org/10.17517/ksutfd.1451439

Öz

Candida auris, first identified in 2009, is a new pathogen that has gained importance due to causing epidemics in various countries. It has taken place among the 10 most feared fungi in the world due to infection-related treatment difficulties, high mortality rates, and resistance properties. In our country, all cases have been reported from Istanbul and Izmir, and our case is the first C. auris fungemia case detected in Anatolia. In this study, a case of candidemia due to C. auris and infections caused by C. auris, risk factors, identification methods, and limitations in treatment options are discussed.

Kaynakça

  • Satoh K, Makimura K, Hasumi Y, Nishiyama Y, Uchida K, Yamaguchi H. Candida auris sp. Nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital. Microbiol Immunol. 2009;53:41-44.
  • Jeffery-Smith A, Taori SK, Schelenz S, Jeffery K, Johnson EM, Borman A, et al. Candida auris: a review of the literature. Clin Microbiol Rev. 2018;31 (1):10-1128.
  • Ayhancı T, Altındiş M. Hızla yayılan çoklu ilaca dirençli maya mantarı: Candida auris. Turk Hij Den Biyol Derg.. 2020;77(1):123-136.
  • Tsay S, Kallen A, Jackson BR, Chiller TM, Vallabhaneni S. Approach to the investigation and management of patients with Candida auris, an emerging multidrug-resistant yeast. Clinical Infectious Diseases 2018;66(2):306-311.
  • Alp Ş, Akdağlı SA. Candida auris ve antifungal ilaçlara direnç mekanizmaları. Mikrobiyol Bul. 2021;55(1):99-112.
  • Hyde KD, Al-Hatmi A, Andersen B, Boekhout T, Buzina W, Dawson TL, et al. The world’s ten most feared fungi. Fungal Divers. 2018;93(1):161-194.
  • Centers for Disease Control and Prevention. Recommendations for identification of Candida auris. https://www.cdc.gov/fungal/diseases/candidiasis/ recommendations.html
  • Calvo B, Melo AS, Perozo-Mena A, Hernandez M, Francisco EC, Hagen F, et al. First report of Candida auris in America: clinical and microbiological aspects of 18 episodes of candidemia. J Infect. 2016;73(4):369-374.
  • Schelenz S, Hagen F, Rhodes JL, Abdolrasouli A, Chowdhary A, Hall A, et al. First hospital outbreak of the globally emerging Candida auris in a European hospital. Antimicrob Resist Infect Control. 2016;5(1):1-7.
  • Kurt AF, Kuskucu MA, Balkan II, Baris A, Yazgan Z, Öz AS, et al. Candida auris Fungemia and a local spread taken under control with infection control measures: First report from Turkey. Indian J Med Microbiol. 2021;39(2):228-230.
  • Kömeç S, Karabıçak N, Ceylan AN, Gülmez A, Özalp O. Türkiye İstanbul’dan bildirilen üç Candida auris olgusu. Mikrobiyol Bul. 2021;55(3):452-460.
  • Bölükbaşı Y, Orhun G, Kuşkucu MA, Çağatay A, Önel M, Öngen B, et al. Türkiye’de ilk COVID-19 pozitif Candida auris fungemi olgusu. Mikrobiyol Bul. 2021;55(4):648-655.
  • Kulaklı K, Arslan N, Gürsan O, Özkütük, A. İzmir’den ilk Candida auris izolasyonu: Amputasyon ile sonuçlanan polimikrobiyal diyabetik ayak enfeksiyonu. Turk Mikrobiyol Cemiy Derg. 2023;53(1):47-54.
  • Morales-López SE, Parra-Giraldo CM, Ceballos-Garzón A, Martínez HP, Rodríguez GJ, Álvarez-Moreno CA, et al. Invasive infections with multidrug-resistant yeast Candida auris, Emerg Infect Dis. 2017;23(1):162-164.
  • Chowdhary A, Anil Kumar V, Sharma C, Prakash A, Agarwal K, Babu R, et al. Multidrug-resistant endemic clonal strain of Candida auris in India. Eur J Clin Microbiol Infect Dis. 2014;33(6):919-926.
  • Rudramurthy SM, Chakrabarti A, Paul RA, Sood P, Kaur H, Capoor MR, et al. Candida auris candidaemia in Indian ICUs: analysis of risk factors. J Antimicrob Chemother. 2017; 72:1794–1801.
  • Mizusawa M, Miller H, Green R, Lee R, Durante M, Perkins R, et al. Can multidrug-resistant Candida auris be reliably identified in clinical microbiology laboratories? J Clin Microbiol. 2017;55(2):638-640.
  • Kim MN, Shin JH, Sung H, Lee K, Kim EC, Ryoo N, et al. Candida haemulonii and closely related species at 5 university hospitals in Korea: identification, antifungal susceptibility, and clinical features. Clin Infect Dis. 2009;48(6):57-61.
  • Chow NA, Muñoz JF, Gade L, Berkow EL, Li X, Welsh RM, et al. Tracing the evolutionary history and global expansion of Candida auris using population genomic analyses. MBio. 2020;11(2):10-1128.
  • Adams E, Quinn M, Tsay S, Poirot E, Chaturvedi S, Southwick K, et al. Candida auris in healthcare facilities. Emerg Infect Dis. 2018;24(10):1816-1824.

Türkiye’de Candida auris Kandidemisi: Anadolu’da İlk Olgu

Yıl 2025, Cilt: 20 Sayı: 1, 91 - 95
https://doi.org/10.17517/ksutfd.1451439

Öz

İlk kez 2009 yılında tanımlanan Candida auris, çeşitli ülkelerde salgınlara neden olmasından dolayı önem kazanmış yeni bir patojendir. Enfeksiyona bağlı tedavi zorlukları, yüksek ölüm oranları ve direnç özellikleri nedeni ile dünyanın en korkulan 10 mantarı arasında yerini almıştır. Bugüne kadar ülkemizde bildirilen tüm olgular İstanbul ve İzmir'den bildirilmiş olup, olgumuz Anadolu'da tespit edilen ilk C. auris fungemi olgusudur. Bu çalışmada C. auris'e bağlı bir kandidemi olgusu ve C. auris'in neden olduğu enfeksiyonlar, risk faktörleri, tanımlama yöntemleri ve tedavi seçeneklerindeki sınırlamalar tartışılmıştır.

Kaynakça

  • Satoh K, Makimura K, Hasumi Y, Nishiyama Y, Uchida K, Yamaguchi H. Candida auris sp. Nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital. Microbiol Immunol. 2009;53:41-44.
  • Jeffery-Smith A, Taori SK, Schelenz S, Jeffery K, Johnson EM, Borman A, et al. Candida auris: a review of the literature. Clin Microbiol Rev. 2018;31 (1):10-1128.
  • Ayhancı T, Altındiş M. Hızla yayılan çoklu ilaca dirençli maya mantarı: Candida auris. Turk Hij Den Biyol Derg.. 2020;77(1):123-136.
  • Tsay S, Kallen A, Jackson BR, Chiller TM, Vallabhaneni S. Approach to the investigation and management of patients with Candida auris, an emerging multidrug-resistant yeast. Clinical Infectious Diseases 2018;66(2):306-311.
  • Alp Ş, Akdağlı SA. Candida auris ve antifungal ilaçlara direnç mekanizmaları. Mikrobiyol Bul. 2021;55(1):99-112.
  • Hyde KD, Al-Hatmi A, Andersen B, Boekhout T, Buzina W, Dawson TL, et al. The world’s ten most feared fungi. Fungal Divers. 2018;93(1):161-194.
  • Centers for Disease Control and Prevention. Recommendations for identification of Candida auris. https://www.cdc.gov/fungal/diseases/candidiasis/ recommendations.html
  • Calvo B, Melo AS, Perozo-Mena A, Hernandez M, Francisco EC, Hagen F, et al. First report of Candida auris in America: clinical and microbiological aspects of 18 episodes of candidemia. J Infect. 2016;73(4):369-374.
  • Schelenz S, Hagen F, Rhodes JL, Abdolrasouli A, Chowdhary A, Hall A, et al. First hospital outbreak of the globally emerging Candida auris in a European hospital. Antimicrob Resist Infect Control. 2016;5(1):1-7.
  • Kurt AF, Kuskucu MA, Balkan II, Baris A, Yazgan Z, Öz AS, et al. Candida auris Fungemia and a local spread taken under control with infection control measures: First report from Turkey. Indian J Med Microbiol. 2021;39(2):228-230.
  • Kömeç S, Karabıçak N, Ceylan AN, Gülmez A, Özalp O. Türkiye İstanbul’dan bildirilen üç Candida auris olgusu. Mikrobiyol Bul. 2021;55(3):452-460.
  • Bölükbaşı Y, Orhun G, Kuşkucu MA, Çağatay A, Önel M, Öngen B, et al. Türkiye’de ilk COVID-19 pozitif Candida auris fungemi olgusu. Mikrobiyol Bul. 2021;55(4):648-655.
  • Kulaklı K, Arslan N, Gürsan O, Özkütük, A. İzmir’den ilk Candida auris izolasyonu: Amputasyon ile sonuçlanan polimikrobiyal diyabetik ayak enfeksiyonu. Turk Mikrobiyol Cemiy Derg. 2023;53(1):47-54.
  • Morales-López SE, Parra-Giraldo CM, Ceballos-Garzón A, Martínez HP, Rodríguez GJ, Álvarez-Moreno CA, et al. Invasive infections with multidrug-resistant yeast Candida auris, Emerg Infect Dis. 2017;23(1):162-164.
  • Chowdhary A, Anil Kumar V, Sharma C, Prakash A, Agarwal K, Babu R, et al. Multidrug-resistant endemic clonal strain of Candida auris in India. Eur J Clin Microbiol Infect Dis. 2014;33(6):919-926.
  • Rudramurthy SM, Chakrabarti A, Paul RA, Sood P, Kaur H, Capoor MR, et al. Candida auris candidaemia in Indian ICUs: analysis of risk factors. J Antimicrob Chemother. 2017; 72:1794–1801.
  • Mizusawa M, Miller H, Green R, Lee R, Durante M, Perkins R, et al. Can multidrug-resistant Candida auris be reliably identified in clinical microbiology laboratories? J Clin Microbiol. 2017;55(2):638-640.
  • Kim MN, Shin JH, Sung H, Lee K, Kim EC, Ryoo N, et al. Candida haemulonii and closely related species at 5 university hospitals in Korea: identification, antifungal susceptibility, and clinical features. Clin Infect Dis. 2009;48(6):57-61.
  • Chow NA, Muñoz JF, Gade L, Berkow EL, Li X, Welsh RM, et al. Tracing the evolutionary history and global expansion of Candida auris using population genomic analyses. MBio. 2020;11(2):10-1128.
  • Adams E, Quinn M, Tsay S, Poirot E, Chaturvedi S, Southwick K, et al. Candida auris in healthcare facilities. Emerg Infect Dis. 2018;24(10):1816-1824.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Hizmetleri ve Sistemleri (Diğer)
Bölüm Olgu Sunumları
Yazarlar

Filiz Orak 0000-0001-5153-7391

Damla Gülderen 0000-0002-6645-9266

Yavuz Orak 0000-0002-8356-6223

Hafize Öksüz 0000-0001-5963-6861

Erken Görünüm Tarihi 24 Mart 2025
Yayımlanma Tarihi
Gönderilme Tarihi 12 Mart 2024
Kabul Tarihi 19 Haziran 2024
Yayımlandığı Sayı Yıl 2025 Cilt: 20 Sayı: 1

Kaynak Göster

AMA Orak F, Gülderen D, Orak Y, Öksüz H. Türkiye’de Candida auris Kandidemisi: Anadolu’da İlk Olgu. KSÜ Tıp Fak Der. Mart 2025;20(1):91-95. doi:10.17517/ksutfd.1451439