Anti-Staphylococcal Activity of Verbascum thapsus L. against Methicillin-Resistant Staphylococcus aureus

Year 2017, Volume: 9 Issue: 1, 53 - 57, 23.03.2017

Gorkem Dulger , Tulay Tutenocakli , Basaran Dulger

https://doi.org/10.18521/ktd.296650

Abstract

Present study was conducted to investigate
the anti-Staphylococcal activity
of ethanol extract obtained from the leaves of Verbascum thapsus L. (Scrophulariaceae) against
Methicillin-resistant Staphylococcus
aureus (MRSA) by agar–well diffusion method and microdilution method. The
ethanol extract showed antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) strains (MIC <1024 µg/mL). When compared with
Methicillin and Gentamicin, the extract was more effective against MRSA
strains. It is therefore suggested that the extract obtained from V. thapsus could be used as an anti-Staphylococcal
agent. 

Keywords

Verbascum thapsus L., Agar-well diffusion method, microdilution method, Methicillin-resistant Staphylococcus aureus

Methicillin-Dirençli Staphylococcus aureus Bakterilerine Karşı Verbascum thapsus L. Bitkisinin Anti-Staphylococcal Aktivitesi

Abstract

Bu çalışmada, Verbascum thapsus L. (Scrophulariaceae)
bitkisinin yapraklarından elde edilen etanol ekstraktının anti-Staphylococcal
aktivitesi Methicillin-Dirençli Staphylococcus aureus (MRSA) bakterilerine
karşı Agar-kuyu difüzyon metodu ve mikrodilüsyon metodu ile araştırılmıştır.
Etanol ekstraktı Methicillin-Dirençli Staphylococcus
aureus (MRSA) bakterilerine karşı (MIC
<1024 µg/mL) antibakteriyal bir aktivite göstermiştir. Methicillin ve
Gentamicin antibiyotikleri ile karşılaştırıldığında, ekstraktın MRSA strainlerine(suşlarına)
karşı oldukça etkili olduğu saptanmıştır. Bu nedenle bitkinin bir anti-Staphylococcal
ajan olarak kullanılabilirliği önerilmektedir. (Bu nedenle bitkinin bir
anti-Staphylococcal ajan olarak kullanılabilirliği in vitro olarak uygun
bulunmuş ve  in vivo çalışmaların
yapılması gerektiği düşünülmüştür)

Keywords

Verbascum thapsus L., Agar-kuyu difüzyon metodu, Mikrodilüsyon metodu, Methicillin-Dirençli Staphylococcus aureus

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