Serum Sistatin-C Düzeyleri Diyastolik Kalp Yetmezliğinde Öngördürücü Olabilir

Yıl 2018, Cilt: 10 Sayı: 2, 194 - 197, 15.08.2018

Osman Kayapınar , Cem Özde , Adnan Kaya

https://doi.org/10.18521/ktd.391986

Öz

Özet :

Amaç: Önceden diyastolik kalp yetmezliği
sistolik kalp yetmezliğinin gibi değerlendirilirken günümüzde bunların
birbirinden ayrı patofizyolojik mekanizmalarla ilerlediği bilinmektedir. Biz bu
çalışmada serum Sistatin C konsantrasyonu ile kalbin diyastolik fonksiyonları
arasındaki ilişkiyi göstermeyi denedik.

Yöntem: Bu çalısmaya Mayıs 2010 ve Eylül
2010 tarihleri arasında Düzce Universitesi Tıp Fakültesi  Hastanesi Kardiyoloji polikliniğine başvuran
bireyler dahil edildi. Deneklerin diyastolik parametreleri değerlendirildi ve
Sistatin C düzeyleri çalışıldı.Denekler diyastolik fonksiyonlarına göre normal
,grade 1, grade 2 olarak üç gruba ayrıldı ve serum sistain-c düzeyi ile bu
gruplar arasında ilişki araştırıldı.

 

Bulgular: Bu çalışmada, Grade I ve Grade II
diyastolik disfonksiyonu olan denekler ile diyastolik fonksiyonu olmayan
denekler serum Sistatin C seviyelerine göre karşılaştırıldı. Diyastolik
disfonksiyon olan gruplarda Sistatin C düzeyinde anlamlı düzeyde artmış olduğu
gösterildi (normal -grade 1:p<0,0001,Normal-grade 2: P<0,004). Sistatin C
değeri için cutof değerini 0,997 ng/ml olarak bulduk. Bu noktada  sistatin C nin diyastolik disfonsiyonu
göstermede spesifitesi  % 80,
sensitivitesi

% 78.95 bulundu . 

Sonuç: Serum sistain C düzeyi diyastolik
disfonksiyonun erken tespitinde ve takibinde faydalı olabilir.

Abstract:

Aim: Formerly diastolic heart failure
eveluated as sistolic heart failure but nowadays we know their distinc
patophisyolojical mechanism.In this study we tried to Show the relations
between diastolic dysfunction and serum cyctatin C consantrations. 

Methods : We included the individuals  who admitted to cardiology clinic of Düzce
University Medical Faculty between May 2010 and September 2010. We evaluate the
serum cystatin C consantrations and 
diastolic dysfunction among 88 person. we evoluated the diastolic parameters
with 2D echocardiography , TDI and PW doppler mesuraments.The 88 study
participants were categorized according to their diastolic parameters into
three groups normal ,grade 1 and grade 2. We made cystatistical analysis in
each groups and parameters.

Results: İn this study the participants
who has grade 1 and grade 2 diastolic disfunction were compaired with normal
participants (who has normal Diastolic function) according to their serum
cycstatin C consentrations.We shown the sytatisticly significant incrise of
serum cycstatin C levels in the group of diastolic disfunction Grade 1 and
Grade 2.(nomal-grade 1:p<0,0001,normal-grade 2:p<0,004). And we find that
the cut off ratio for Cystatin C was 0,997 ng/ml . On this point Cystatin c was
%80 specific and %78.95 sensitive for diastolic disfunction.

Conclusion: Serum Cystatin C levels may be
useful in the early detection and monitoring of diastolic dysfunction.

Anahtar Kelimeler

diyastolik kalp yetmezligi, sistatin c, ekokardiyografi

Serum Cystatin-C Levels Could Be Predictor of Diastolic Heart Failure

Öz

Abstract:

Aim: Formerly diastolic heart failure
eveluated as sistolic heart failure but nowadays we know their distinc
patophisyolojical mechanism.In this study we tried to Show the relations
between diastolic dysfunction and serum cyctatin C consantrations. 

Methods : We included the individuals  who admitted to cardiology clinic of Düzce
University Medical Faculty between May 2010 and September 2010. We evaluate the
serum cystatin C consantrations and 
diastolic dysfunction among 88 person. we evoluated the diastolic parameters
with 2D echocardiography , TDI and PW doppler mesuraments.The 88 study
participants were categorized according to their diastolic parameters into
three groups normal ,grade 1 and grade 2. We made cystatistical analysis in
each groups and parameters.

Results: İn this study the participants
who has grade 1 and grade 2 diastolic disfunction were compaired with normal
participants (who has normal Diastolic function) according to their serum
cycstatin C consentrations.We shown the sytatisticly significant incrise of
serum cycstatin C levels in the group of diastolic disfunction Grade 1 and
Grade 2.(nomal-grade 1:p<0,0001,normal-grade 2:p<0,004). And we find that
the cut off ratio for Cystatin C was 0,997 ng/ml . On this point Cystatin c was
%80 specific and %78.95 sensitive for diastolic disfunction.

Conclusion: Serum Cystatin C levels may be
useful in the early detection and monitoring of diastolic dysfunction.

Key Words: Diastolic heart failure, Cystatin C,
Echocardiography

Anahtar Kelimeler

dyastolic heart failure, cystatin c, echocardiography

Kaynakça

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