Sigara İçenlerde Nazal Mukosiliyer Aktivitedeki Değişimler

Year 2018, Volume: 10 Issue: 3, 269 - 275, 23.10.2018

İbrahim Solak , Kamile Marakoglu , Selma Pekgor , Nisa Çetin Kargın , Necat Alataş , Mehmet Ali Eryılmaz

https://doi.org/10.18521/ktd.344288

Cited By: 3

Abstract

 Amaç: Nazal mukosiliyer aktivite nazal mukozal fonksiyonların iyi bir göstergesi olup vücut için önemli savunma mekanizmalarından birisidir. Bu çalışmanın amacı, nazal mukosiliyer aktiviteyi etkileyen diğer faktörleri çalışma dışı bırakarak, sigara içiminin ve sigara miktarının nazal mukosiliyer aktivite üzerindeki etkisini araştırmaktır. 

Gereç ve Yöntem: Yüz yirmi üç sigara içen (vaka grubu) ve yetmiş dört sigara içmeyen (kontrol grubu) olmak üzere 18-55 yaş arasındaki toplam yüz doksan yedi hasta çalışmaya alındı. Tüm katılımcılara, sakarin transfer zamanı (STT) testi, CO ölçümü, Fagerstrom Testi ve sigara içme özelliklerini içeren bir anket uygulandı.

Bulgular: Vaka ve kontrol grubu arasında mukosiliyer aktiviteyi etkileyen yaş ve beden kitle indeksi parametreleri açısından istatistiksel olarak anlamlı fark bulunmadı. Bu çalışmada, olgu ve kontrol grubu arasındaki mukosiliyer transfer süresinde istatistiksel olarak anlamlı bir fark tespit edildi. Ayrıca, STT ile günde sigara içilen sigara sayısı, STT ve paket yılı, STT ve sigara içilen yıllar arasında pozitif bir korelasyon tespit edildi.

Sonuç: Sonuç olarak bu çalışmada sigaranın nazal mukosiliyer sistemi bozduğu ve bu durumun içilen sigara miktarı ve süresiyle doğru orantılı olarak gerçekleştiği gösterilmiştir

Keywords

Sigara, Sakarin Transfer Süresi, Mukosiliyer Aktivite

Nasal Mucociliary Activity Changes in Smokers

Abstract

Objective: Nasal mucociliary activity, which is a good indicator of nasal mucosal function, is one of the most important defense mechanisms of the body. The aim of the present study is to investigate the effect of smoking and cigarette consumption on nasal mucociliary activity per se by singling out other factors affecting nasal mucociliary activity. Methods: One hundred ninety seven patients aged 18-55 years, one hundred twenty three smokers (case group) and seventy four non-smokers (control group), were included in the present study. Saccharin transfer time (STT) test, CO measurement, Fagerstrom Test for Nicotine Dependence, and a questionnaire including smoking characteristics were applied to all participants.

Results: No statistically significant difference was determined between the case and control group in terms of age and body mass index parameters affecting mucociliary activity. In the present study, a statistically significant difference was determined in the mucociliary transfer time between the case and the control group. Moreover, a positive correlation between saccharin transfer time (STT) and number of cigarettes smoked per day, STT and package-year, STT and total smoking years was also determined.

Conclusions: In conclusion, smoking has been in the present study determined to deteriorate nasal mucociliary system with a direct proportion to the amount and total duration of smoking.

Keywords

Smoking, Saccharin Transfer Time, Mucociliary Activity

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