A new predictor for prediabetes: Chemerin

Yıl 2023, Cilt: 15 Sayı: 1, 52 - 58, 15.03.2023

Emine Ergün , Arzu Or Koca , Esin Beyan , Derun Taner Ertuğrul , Tolga Akkan , Kürşat Dal

https://doi.org/10.18521/ktd.1148541

Öz

Objective: It was aimed to investigate irisin and chemerin levels in prediabetic individuals and their value in predicting prediabetes.
Method: Thirty-eight prediabetic patients aged 18-65 years (22 impaired fasting glucose (IFG), 10 impaired glucose tolerance (IGT), 6 patients with coexisting IFG and IGT) and thirty-five healthy volunteers were included in which was designed as a cross-sectional study. The basic demographic characteristics of all participants in the case and control groups were compared with the serum chemerin, irisin, creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), high-density lipoprotein (HDL-cholesterol), low-density lipoprotein (LDL-cholesterol), triglyceride (TG), free thyroxine (sT4), and thyroid-stimulating hormone (TSH) levels.
Result: Serum chemerin level was found to be higher in the prediabetic group (p=0.03), while no significant difference was found for the irisin level between the two groups. In the multivariate logistic regression analysis, we showed that chemerin was an independent risk factor in predicting prediabetes. There was a positive correlation (p=0.01, r=0.279) between all participants' body mass index (BMI) and chemerin level and a negative correlation between irisin level and high-density lipoprotein cholesterol (HDL-C) level, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (p=0.04 r=-0.295, p=0.01 r=-0.407, respectively).
Conclusion: Chemerin is a new generation chemokine that predicts prediabetes. Studies aimed at irisin and chemerin may provide important role to prevent the prediabetes to Type 2 diabetes progression.

Anahtar Kelimeler

Chemerin, Diabetes mellitus, Irisin, Prediabetic state, Predictive value of tests

Prediyabet için yeni bir prediktör: Kimerin

Öz

Amaç: Prediyabetik bireylerde irisin ve kimerin düzeylerini ve bunların prediyabeti öngörmedeki değerini araştırmak amaçlandı.
Metod: Kesitsel bir çalışma olan dizayn edilen çalışmamıza; 18-65 yaş arası 38 prediyabetik hasta (22 bozulmuş açlık glukozu (IFG), 10 bozulmuş. glukoz toleransı (IGT), 6 IFG ve IGT birlikte bulunan hasta) ve 35 gönüllü sağlıklı kişi dahil edildi. Vaka ve kontrol grubundaki tüm katılımcıların temel demografik özellikleri ile serum kimerin, irisin, kreatinin, Alanin Aminotransferaz (ALT), Aspartat Aminotransferaz (AST), düşük dansiteli lipoprotein (LDL-kolesterol), yüksek dansiteli lipoprotein (HDL-kolesterol), trigliserit (TG), serbest tiroksin (sT4) ve tiroid stimülan hormon (TSH) düzeylerinin sonuçları karşılaştırıldı.
Bulgular: Her iki grup arasında irisin düzeyi için fark saptanmazken, kimerin düzeyi prediyabetik grupta daha yüksek saptandı (p=0.03). Yaptığımız çok değişkenli lojistik regresyon analizinde kimerinin prediyabeti ön gördürücü bağımsız bir risk faktörü olduğunu gösterdik. Ayrıca tüm katılımcıların beden kitle indeksi (BKİ) ile kimerin düzeyi arasında pozitif korelasyon (p=0.01, r=0.279); irisin düzeyi ile high density lipoprotein kolesterol (HDL-C) düzeyi ve Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) arasında negatif korelasyon (sırasıyla; p=0.04 r=-0.295, p=0.01 r=-0.407) saptadık.
Sonuç: Kimerin prediyabeti predikte eden yeni nesil bir kemokindir. İrisin ve kimerin hedefli yeni çalışmalar prediyabetin diyabete dönüşmesinin önlenmesinde önemli aşamalar sağlayabilir.

Anahtar Kelimeler

Kimerin, Diyabetes mellitus, İrisin, Prediyabetik durum, Testlerin prediktif değeri

Kaynakça

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