Allergic Conjunctivitis

Yıl 2017, Cilt: 9 Sayı: 2, 150 - 153, 15.03.2017

Prof. Dr. Figen Gülen

Öz

Abstract

Allergic conjonktivitis is one of the most common allergic conditions worldwide. Ocular itching is the pathognomonic symptom  important for differential diagnosis from other ocular conditions. Seasonal and perennial allergic conjonktivitis arethe most common forms. It is usually seen together with systemic allergic disorders, especially allergic rihinitis with %50-75. Alergic konjonktivitis is differentiated into a spectrum from the benign seasonaland perennial allergic konjonktivitis and giant papillary conjunctivitis to the chronic, morbid, and potentially sight-threatening vernal keratoconjunctivitis, atopic keratoconjunctivitis  and contact blepharoconjunctivitis. Specific IgE levels and skin prick tests can be used for elevating allergen sensitivity in allergic conjonktivitis. Many sistemic and topical agents were used for treatment of allergic conjonktivitis. Topical antihistamines are more effective and reliable for ocular allergies. Vernal keratoconjunctivitis, atopic keratoconjunctivitis and contact blepharoconjunctivitis are more severe forms and immunomodulators suchas cyclosporin A can be used for treatment

Anahtar Kelimeler

Allergy, allergic conjonktivitis, keratoconjonktivitis, seasonal, perennial

Alerjik Konjonktivit

Öz

Öz

Alerjik konjonktivit, dünya genelinde en yaygın alerjik durumlardan biridir. Patognomonik bulgusu, oküler kaşıntı olup diğer oküler durumlardan ayrımda önemlidir. Mevsimsel ve perennial alerjik konjonktivit en yaygın formlarıdır. Diğer sistemik alerjik hastalıklarla sıklıkla birlikte bulunur, bunların başında alerjik rinit gelmekte  olup birlikteliği %50-75’tir. Alerjik konjonktivit benign mevsimsel veya perennial alerjik konjonktivit, devpapiller konjonktivitten, kronik, morbit, görmeyi tehdit eden vernal keratokonjonktivit, atopik keratokonjonktivit, kontakt blefarokonjonktivite uzanan değişken bir spektruma sahiptir. Alerjik konjonktivitte duyarlı olunan alerjenin belirlenmesi amacıyla deri pricktesti uygulanabilir veya spesifik IgE düzeylerine bakılabilir. Alerjik konjonktivit tedavisinde sistemik, topikal birçok ajan kullanılmıştır. Oküler alerji tedavisinde topikal antihistaminikler daha güvenli ve etkindir. Vernal keratokonjonktivit, atopikkeratokonjonktivit,  kontakt blefarokonjonktivit daha ağır formlar olup kortikosteroidler, siklosporin A gibi immünomodülatör ilaçlar kullanmak gerekebilir.

Anahtar Kelimeler

Alerji, alerjik konjonktivit, keratokonjonktivit, mevsimsel, perennial

Kaynakça

• Kaynaklar 1.Ackerman S, Smith LM, Gomes PJ. Ocular itch associated with al-lergic conjunctivitis: latest evidence and clinical management.T herAdv Chronic Dis. 2016 Jan;7(1):52-67. 2.O'Brien TP.Allergic conjunctivitis: an update on diagnosis and ma-nagement. Curr Opin Allergy Clin Immunol. 2013 Oct;13(5):543-9. 3.Rosario N, Bielory L. Epidemiology of allergic conjunctivitis. CurrOpin Allergy Clin Immunol 2011; 11:471–476. 4.Miraldi Utz V, Kaufman AR. Allergic eye disease .Pediatr Clin NorthAm. 2014 Jun;61(3):607-20. 5.Burbach G, Heinzerling L , Rohnelt C, Bergmann K, Behrendt H.and Zuberbier T. Ragweed sensitization in Europe – GA(2)LEN studysuggests increasing prevalence. Allergy 2009 64: 664–665. 6.Moloney G, McCluskey PJ. Classifying and managing allergic con-junctivitis. Med Today 2007; 8:16–21. 7.Leonardi, A. Allergy and allergic mediators in tears. Exp Eye Res2013;117: 106–117. 8.Gomes, P. Trends in prevalence and treatment of ocular allergy. CurrOpin Allergy Clin Immunol 2014;14:451–456. 9.De Smedt, S., Wildner, G. and Kestelyn, P. Vernal keratoconjunc-tivitis: an update. Br J Ophthalmol 2013;97: 9–14. 10.Tuncer A, Yüksel H, Konjunktivit. Allerjik rinit tanı ve tedavi rehbe-ri 2012; 102-103. 11.American Academy of Ophthalmology Cornea/External Disease Pa-nel. Preferred practice pattern guidelines. Conjunctivitis: limited re-vision. San Francisco, CA: American Acedemy of Ophthalmology; 2011. 12.Bielory BP, O’Brien TP, Bielory L. Management of seasonal aller-gic conjunctivitis:guide to therapy. Acta Ophthalmol 2012;90:399–407. 13.Simons FE, Simons KJ. Histamine and H1-antihistamines: celebra-ting a century of progress. J Allergy Clin Immunol 2011;128:1139–1150. 14.Wallace DV, Dykewicz MS, Bernstein DI, et al. The diagnosis andmanagement of rhinitis: an updated practice parameter. J AllergyClin Immunol 2008;122:1–84. 15.Ashrafzadeh A, Raizman MB. New modalities in the treatment of ocu-lar allergy. Int Ophthalmol Clin. 2003 Winter;43(1):105-110. 16.Çoban-Karataş M, Özkale Y, Altan-Yaycıoğlu R, Sızmaz S, Pelit A,Metindoğan S et al. .Efficacy of topical 0.05% cyclosporine treat-ment in children with severe vernal keratoconjunctivitis. Turk J Pe-diatr. 2014;56(4):410-417. 17.Kari O, Saari KM. Updates in the treatment of ocular allergies. J Asth-ma Allergy 2010; 3:149–158.