Sepsis and Meningitis at Prematurity

Yıl 2017, Cilt: 9 Sayı: 4, 50 - 63, 20.07.2017

Prof. Dr. Eren Özek

Öz

Abstract

Neonatal sepsis is a clinical syndrome in which systemic infection signs andsymptoms occur in the first month of life. Despite the advancements in the field ofneonatology, it is a major cause of mortality and morbidity in preterm infants. A swift diagnosis and appropriate antibiotics are life-saving. The diagnosis is based on bothclinical and laboratory findings. Isolation of the microorganism is the gold standard test for diagnosis. The microorganisms associated with neonatal sepsis and neonatal meningitis are the same and they vary depending on postnatal and gestational age. Over the last several years even though the mortality rates have decreased, the morbidity rates of neonatal meningitis still remain high. The aim of this review is to evaluate the epidemiology, etiology, pathogenesis, clinical findings and treatment of sepsis and meningitis in preterm infants.

Anahtar Kelimeler

preterm, sepsis, meningitis

Prematürede Sepsis ve Menenjit

Öz

Öz

Neonatal sepsis yaşamın ilk ayı içerisinde sistemik enfeksiyon bulgu ve semptomlarının olduğu klinik bir sendromdur. Neonatoloji alanındaki gelişmelere rağmensepsis prematüre bebeklerde major mortalite ve morbidite nedenlerinden birisi olup yenidoğan yoğun bakım ünitelerindeki (YDYBÜ) en önemli sorunlardan birini oluşturmaktadır. Tanının hızlı bir şekilde konarak uygun antibiyotik ve destek tedavisinin başlanması hayat kurtarıcıdır. Sepsis tanısı klinik ve laboratuvar bulgularının birlikte değerlendirilmesi ile konulmaktadır. Mikroorganizmanın kanda izolasyonu enspesifik yöntemdir ve altın standart olarak kabul edilmektedir. Bakteriyel menenjitler de yenidoğan döneminde yüksek mortalite ve morbiditeye neden olan ciddi en-feksiyonlardır. Yenidoğan menenjitinde görülen mikroorganizmalar postnatal ve gebelik yaşına bağlıdır ve yenidoğan sepsisi ile aynıdır. Son yıllarda mortalite oranı azalsa da yenidoğan menenjitinin morbidite oranı pek değişim göstermemiştir. Bu derlemede prematüre bebeklerde görülen sepsis ve menenjitin epidemiyolojisi, etiyolojisi,patogenezi, klinik bulguları ve yaklaşımının gözden geçirilmesi amaçlanmıştır.

Anahtar Kelimeler

Prematüre, sepsis, menenjit

Kaynakça

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