The Effectiveness of Whole Body Magnetic Resonance Imaging Used in Health Screening Programs in Early Stage Cancer Diagnosis

Yıl 2024, Cilt: 10 Sayı: 3, 101 - 108, 28.10.2024

Demet Doğan , Kağan Gökçe

https://doi.org/10.30934/kusbed.1520977

Öz

Objective: We aim to present the findings and effectiveness of Whole Body Magnetic Resonance Imaging (WBMRI), which we use in the Health Screening Program (HSP) to diagnose cancer in early stage.

Methods: This retrospective study was conducted between January 2017-February 2023. 393 individuals, between the ages of 18 and 85, who underwent WBMRI for HSP purposes, were included. The mean age was 50.

Results: Malignancy suspicious lesions were observed in the head/neck region in 25 cases. Additional Magnetic Resonance (MRI) and Ultrasound (US) were performed. Mediastinal pathology was observed in 23 cases, and non-mediastinal thoracic pathologies were detected in 15. Therefore thorax Computed Tomography (CT), mammography, and breast US were performed. Benign lesions were observed in the liver in 44 cases, and US was performed. Malignancy-suspicious lesions in the liver were observed in 4, and dynamic abdominal MRI was performed. Cholelithiasis was observed in 16, and confirmed by US. The most common renal findings were; cysts and pelvicalyceal ectasia. Adrenal adenoma was observed in 5 cases. Two of the females had suspicion of gynecological malignancy. Massive diffuse concentric wall thickening was observed in the sigmoid colon, and colonoscopy was performed on one male. Musculoskeletal benign lesions were detected in 99 cases, and malignancy-suspicious lesions were detected in 35. Additional examinations such as US, CT, MRI, PET-CT, scintigraphy, and colonoscopy were performed on 172 cases. Malignancy was detected in 11 cases (2.8%).

Conclusion: WBMRI is a radiation-free, non-invasive, short-term examination method. WBMRI is beneficial in diagnosing early-stage cancer.

Anahtar Kelimeler

Health Screening Program, Whole Body Magnetic Resonance Imaging, Cancer Screening

Etik Beyan

The study obtained ethical approval from the Istanbul Okan University Non-Interventional Clinical Research Ethics Committee at the meeting numbered 169 on 18/10/2023 with decision number 15.

Destekleyen Kurum

No person/organization financially supports the study.

Kaynakça

• Damadian R. Tumor detection by nuclear magnetic resonance. Science. 1971;171.3976:1151-1153. doi:10.1126/science.171.3976.1151.
• Lauterbur PC. Image formation by induced local interactions. Examples employing nuclear magnetic resonance. 1973. Clin Orthop Relat Res. 1989;(244):3-6. doi:10.1038/242190a0. International Wushu Federation. http://www.iwuf.org/ Accessed October 3, 2023.
• Takahara T, Imai Y, Yamashita T, Yasuda S, Nasu S, Van Cauteren M. Diffusion weighted whole body imaging with background body signal suppression (DWIBS): technical improvement using free breathing, STIR and high resolution 3D display. Radiat Med. 2004;22(4):275-282.
• Kwee TC, Takahara T, Ochiai R, et al. Whole-body diffusion-weighted magnetic resonance imaging. Eur J Radiol. 2009;70(3):409-417. doi:10.1016/j.ejrad.2009.03.054.
• Tunariu N, Blackledge M, Messiou C, et al. What's New for Clinical Whole-body MRI (WB-MRI) in the 21st Century. Br J Radiol. 2020;93(1115):20200562. doi:10.1259/bjr.20200562.
• Kalkmann J, Lauenstein T, Stattaus J. Ganzkörperdiffusionsbildgebung in der Onkologie: Technische Aspekte und praktischer Stellenwert [Whole-body diffusion-weighted imaging in oncology: technical aspects and practical relevance]. Radiologe. 2011;51(3):215-219. doi:10.1007/s00117-010-2062-1..
• Stecco A, Trisoglio A, Soligo E, Berardo S, Sukhovei L, Carriero A. Whole-Body MRI with Diffusion-Weighted Imaging in Bone Metastases: A Narrative Review. Diagnostics (Basel). 2018;8(3):45. Published 2018 Jul 9. doi:10.3390/diagnostics8030045.
• Summers P, Saia G, Colombo A, et al. Whole-body magnetic resonance imaging: technique, guidelines and key applications. Ecancermedicalscience. 2021;15:1164. Published 2021 Jan 7. doi:10.3332/ecancer.2021.1164.
• Cieszanowski A, Maj E, Kulisiewicz P, et al. Non-contrast-enhanced whole-body magnetic resonance imaging in the general population: the incidence of abnormal findings in patients 50 years old and younger compared to older subjects. PLoS One. 2014;9(9):e107840. Published 2014 Sep 26. doi:10.1371/journal.pone.0107840.
• Schünemann HJ, Lerda D, Quinn C, et al. Breast Cancer Screening and Diagnosis: A Synopsis of the European Breast Guidelines. Ann Intern Med. 2020;172(1):46-56. doi:10.7326/M19-2125.
• Younis YS, Ali AH, Alhafidhb OKS, et al. Early diagnosis of breast cancer using image processing techniques. Hindawi Journal of Nanomaterials. 2022;(1):2641239. doi:10.1155/2022/2641239.
• Li C, Wang H, Jiang Y, et al. Advances in lung cancer screening and early detection. Cancer Biol Med. Published online May 11, 2022. doi:10.20892/j.issn.2095-3941.2021.0690.
• Pastorino U. Lung cancer screening. Br J Cancer. 2010;102(12):1681-1686. doi:10.1038/sj.bjc.6605660.
• Kim J, Kim KH. Role of chest radiographs in early lung cancer detection. Transl Lung Cancer Res. 2020;9(3):522-531. doi:10.21037/tlcr.2020.04.02.
• Shelley D, Wang VH, Taylor K, et al. Accelerating integration of tobacco use treatment in the context of lung cancer screening: Relevance and application of implementation science to achieving policy and practice. Transl Behav Med. 2022;12(11):1076-1083. doi:10.1093/tbm/ibac076.
• Redberg RF. Cancer risks and radiation exposure from computed tomographic scans: how can we be sure that the benefits outweigh the risks?. Arch Intern Med. 2009;169(22):2049-2050. doi:10.1001/archinternmed.2009.453.
• Schmidt G, Dinter D, Reiser MF, Schoenberg SO. The uses and limitations of whole-body magnetic resonance imaging. Dtsch Arztebl Int. 2010;107(22):383-389. doi:10.3238/arztebl.2010.0383.
• Frericks BB, Meyer BC, Martus P, Wendt M, Wolf KJ, Wacker F. MRI of the thorax during whole-body MRI: evaluation of different MR sequences and comparison to thoracic multidetector computed tomography (MDCT). J Magn Reson Imaging. 2008;27(3):538-545. doi:10.1002/jmri.21218.
• Biederer J, Hintze C, Fabel M. MRI of pulmonary nodules: technique and diagnostic value. Cancer Imaging. 2008;8(1):125-130. Published 2008 May 19. doi:10.1102/1470-7330.2008.0018.
• Li S, Sun F, Jin ZY, Xue HD, Li ML. Whole-body diffusion-weighted imaging: technical improvement and preliminary results. J Magn Reson Imaging. 2007;26(4):1139-1144. doi:10.1002/jmri.21074.
• Li B, Li Q, Nie W, Liu S. Diagnostic value of whole-body diffusion-weighted magnetic resonance imaging for detection of primary and metastatic malignancies: a meta-analysis. Eur J Radiol. 2014;83(2):338-344. doi:10.1016/j.ejrad.2013.11.017.
• Koh DM, Blackledge M, Padhani AR, et al. Whole-body diffusion-weighted MRI: tips, tricks, and pitfalls. AJR Am J Roentgenol. 2012;199(2):252-262. doi:10.2214/AJR.11.7866.
• Krüger S, Buck AK, Mottaghy FM, et al. Detection of bone metastases in patients with lung cancer: 99mTc-MDP planar bone scintigraphy, 18F-fluoride PET or 18F-FDG PET/CT. Eur J Nucl Med Mol Imaging. 2009;36(11):1807-1812. doi:10.1007/s00259-009-1181-2.
• Ak I, Sivrikoz MC, Entok E, Vardareli E. Discordant findings in patients with non-small-cell lung cancer: absolutely normal bone scans versus disseminated bone metastases on positron-emission tomography/computed tomography. Eur J Cardiothorac Surg. 2010;37(4):792-796. doi:10.1016/j.ejcts.2009.11.011.
• Nakanishi K, Kobayashi M, Takahashi S, et al. Whole body MRI for detecting metastatic bone tumor: comparison with bone scintigrams. Magn Reson Med Sci. 2005;4(1):11-17. doi:10.2463/mrms.4.11.
• Krüger S, Buck AK, Mottaghy FM, et al. Detection of bone metastases in patients with lung cancer: 99mTc-MDP planar bone scintigraphy, 18F-fluoride PET or 18F-FDG PET/CT. Eur J Nucl Med Mol Imaging. 2009;36(11):1807-1812. doi:10.1007/s00259-009-1181-2.
• Lauenstein TC, Freudenberg LS, Goehde SC, et al. Whole-body MRI using a rolling table platform for the detection of bone metastases. Eur Radiol. 2002;12(8):2091-2099. doi:10.1007/s00330-002-1344-z.
• Rashid RJ, Tahir SH, Kakamad FH, et al. Whole‑body MRI for metastatic workup in patients diagnosed with cancer. Mol Clin Oncol. 2023;18(4):33. Published 2023 Mar 1. doi:10.3892/mco.2023.2629.
• Mosavi F, Ullenhag G, Ahlström H. Whole-body MRI including diffusion-weighted imaging compared to CT for staging of malignant melanoma. Ups J Med Sci. 2013;118(2):91-97. doi:10.3109/03009734.2013.778375.
• Sakurai Y, Kawai H, Iwano S, Ito S, Ogawa H, Naganawa S. Supplemental value of diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) technique to whole-body magnetic resonance imaging in detection of bone metastases from thyroid cancer. J Med Imaging Radiat Oncol. 2013;57(3):297-305. doi:10.1111/1754-9485.12020.
• Akay S, Kocaoglu M, Emer O, Battal B, Arslan N. Diagnostic accuracy of whole-body diffusion-weighted magnetic resonance imaging with 3.0 T in detection of primary and metastatic neoplasms. J Med Imaging Radiat Oncol. 2013;57(3):274-282. doi:10.1111/1754-9485.12026.
• Eissawy MG, Saadawy AMI, Farag K, Akl T, Kamr WH. Accuracy and diagnostic value of diffusion-weighted whole body imaging with background body signal suppression (DWIBS) in metastatic breast cancer. Egypt J Radiol Nucl Med. 2021;52:74. doi:10.1186/s43055-021-00451-y.
• Lauenstein TC, Semelka RC. Emerging techniques: whole-body screening and staging with MRI. J Magn Reson Imaging. 2006;24(3):489-498. doi:10.1002/jmri.20666.
• Eustace SJ, Nelson E. Whole body magnetic resonance imaging. BMJ. 2004;328(7453):1387-1388. doi:10.1136/bmj.328.7453.1387.
• Schmidt GP, Reiser MF, Baur-Melnyk A. Whole-body MRI for the staging and follow-up of patients with metastasis. Eur J Radiol. 2009;70(3):393-400. doi:10.1016/j.ejrad.2009.03.045.
• Smets AM, Deurloo EE, Slager TJE, Stoker J, Bipat S. Whole-body magnetic resonance imaging for detection of skeletal metastases in children and young people with primary solid tumors - systematic review. Pediatr Radiol. 2018;48(2):241-252. doi:10.1007/s00247-017-4013-8.
• Nievelstein RA, Littooij AS. Whole-Body MRI in Pediatric Oncology. Imaging in Pediatric Oncology. 2019;107-135. doi:10.1007/s11547-015-0600-7.
• Han SN, Amant F, Michielsen K, et al. Feasibility of whole-body diffusion-weighted MRI for detection of primary tumour, nodal and distant metastases in women with cancer during pregnancy: a pilot study. Eur Radiol. 2018;28(5):1862-1874. doi:10.1007/s00330-017-5126-z.
• Schlett CL, Rospleszcz S, Korbmacher D, et al. Incidental findings in whole-body MR imaging of a population-based cohort study: Frequency, management and psychosocial consequences. Eur J Radiol. 2021;134:109451. doi:10.1016/j.ejrad.2020.109451.
• Korbmacher-Böttcher D, Bamberg F, Peters A, et al. Long-Term Psychosocial Consequences of Whole-Body Magnetic Resonance Imaging and Reporting of Incidental Findings in a Population-Based Cohort Study. Diagnostics (Basel). 2022;12(10):2356. Published 2022 Sep 28. doi:10.3390/diagnostics12102356.