Antioxidant Safety and Antioxidant-induced Stress

Yıl 2018, Cilt: 11 Sayı: 4, 491 - 496, 15.12.2018

Recep Aslan

https://doi.org/10.30607/kvj.447022

Öz

The safe use
of antioxidants and reliable antioxidant applications are a new and important
area of debate that has been continuing for decades. Today, antioxidant plants,
phytochemicals and products are the most popular supplements. Most of them are
sold without a prescription, even though they are used like a medicine. We know
many scientific reports on the benefits of antioxidants but there are also
studies that question whether antioxidant products have harmful effects. Nowadays
antioxidant safety is the one of the most important medical topics at
oxidant-antioxidant balance and oxidative stress. A physiological balance exists
between oxidants and antioxidants in the organism only when both of the forces are
present. Studies which document that antioxidant supplementation, inhibits the reactions
and effects of free radicals are common. But, it is still unclear which exogen
antioxidants and doses should be used to have an efective defense and also what
safe limit is for use. It is possible that many of antioxidant phytochemicals
and supplements can cause harmful changes in tissues by initiating different
mechanisms. The most important question related to the use of antioxidants and
antioxidant safety is the names, amounts, kinds and forms of them. The term
antioxidative stress is a new strategic word on oxidant-antioxidant balance as
like as oxidative stress. Antioxidants may cause stress in tisssues which
refers to antioxidative stress. An extraordinary attention on antioxidative
stress is a necessity for today's medical disciplines. The further studies are
needed to clarify the harmful effects of antioxidants and antioxidative stress
for the antioxidant safety. We aimed to focuse on the antioxidant-induced
stress. For this reason, some reports on the harmful effects of antioxidants have
been discussed in this paper.

Anahtar Kelimeler

antioxidative stress, harmful effects of antioxidants, antioxidant safety

Antioksidan Güvenliği ve Antioksidan Kaynaklı Stres

Öz

Antioksidanların
güvenli kullanımı ve güvenilir antioksidan uygulamaları, on yıllar boyu devam
edecek yeni ve önemli bir tartışma alanıdır. Günümüzde
antioksidan bitkiler, fitokimyasallar ve antioksidan ürünler en popüler tıbbi
ürünlerdir. Büyük çoğunluğu ilaç gibi kullanılmasına rağmen bu ürünler
reçetesiz satılır. Antioksidanların yararları hakkında birçok bilimsel rapor
biliyoruz, ancak olası zararlı etkilerini sorgulayan araştırmalar ve önemli
raporlar da mevcuttur. Aslında antioksidan güvenliği, oksidan-antioksidan denge
açısından çok önemlidir. Organizmadaki oksidanlar ve antioksidanlar arasındaki
fizyolojik denge, bu kuvvetlerin her ikisi de geçerli olduğunda dengelenir.
Antioksidan takviyesinin serbest radikal ürünleri, reaksiyonları ve etkilerini
engellediğini belgeleyen çalışmalar yaygındır. Ancak, etkili bir antioksidan
savunmaya sahip olmak için hangi ajanların ve hangi miktarların gerekli olduğu
ve hangi dozun kullanım için güvenli limiti yansıttığı hala bilinmemektedir.
Ekzojen antioksidan fitokimyasalların ve eklerin çoğu, farklı mekanizmalar
başlatarak dokularda zararlı değişikliklere neden olabilir. Antioksidan
kullanımı ile ilgili en önemli nokta, antioksidan güvenliği için bunların
çeşitleri, formları ve dozlarıdır. Antioksidatif stres terimi oksidatif stres
gibi oksidan-antioksidan dengesinde yeni bir stratejik kelimedir.
Antioksidanlar, dokuları antioksidatif stres olarak adlandırılan strese
yönlendirebilir. Olağanüstü bir dikkat ve antioksidan strese odaklanmak,
bugünün medikal disiplinleri için bir zorunluluktur. Antioksidan güvenlik için
antioksidan ve antioksidan stresin zararlı etkilerini aydınlatmak için daha
ileri çalışmalara ihtiyaç olduğunu düşünüyoruz. Bu derlemenin amacı antioksidan
kaynaklı strese odaklanmaktır, bu nedenle bu çalışmada antioksidanların zararlı
etkileri hakkındaki mevcut kanıtlar analiz edilmiştir.

Anahtar Kelimeler

Antioksidan güvenliği, antioksidatif stres, antioksidanların zararlı etkileri

Kaynakça

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