Yoğun bakım hastalarında sepsis ve prokalsitonin ilişkisi

Yıl 2019, Cilt: 11 Sayı: 2, 51 - 54, 29.08.2019

Belkız Öngen İpek , Mustafa Erinç Sitar Aslı Karadeniz

Öz

ÖZET

Sepsis, enfeksiyona karşı oluşan konakçı tepkisi
nedeniyle hayatı tehdit eden organ fonksiyon bozukluğu
olarak tanımlanır. Hastane ve yoğun bakımdaki ölüm
nedenlerinin en önemli sebeplerinden birini oluşturur.
Sepsis teşhisi ve prognozu için rutinde altın standart
bir test bulunmamaktadır ancak CRP ve prokalsitonin
sepsis teşhisi ve prognozu için rutinde en çok kullanılan
testlerden ikisidir. Birçok çalışma ile prokalsitonin
rehberli tedavinin antibiyotik kullanımını azalttığı
gösterilmiştir. Prokalsitonin ve/veya CRP, klinisyenlere
rehber olma açısından büyük yararlar sağlasa da,
tek başına bu testlerin ideal test özelliklerini eksiksiz
yerine getirebilmesi zordur. Bu nedenle bilim dünyası
translasyonel tıp temelinde yeni belirteçler arayışına
girmiştir.

SUMMARY

Sepsis is defined as life-threatening organ dysfunction due
to host response to infection. It is definifed one of the most
important causes of death in hospital and intensive care
unit. There is not any gold standard test for diagnosis and
prognosis of sepsis. However, CRP and procalcitonin are
two of the most commonly used tests for the diagnosis and
prognosis of sepsis. Procalcitonin guided therapy has been
shown to reduce antibiotic use in many studies. Procalcitonin
and / or CRP provide great benefits for clinicians but these
tests alone are difficult to fulfill the ideal test specifications.
For this reason, the world of science is looking for new
markers on the basis of translational medicine. 

Anahtar Kelimeler

Sepsis, prokalsitonin

Kaynakça

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